DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amon and PCSK7

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_004707.2	Gene:	PCSK7 / 9159	HGNCID:	8748	Length:	785	Species:	Homo sapiens

Alignment Length:	637	Identity:	247/637 - (38%)
Similarity:	323/637 - (50%)	Gaps:	61/637 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 WSWLLAPFLLLHWASAGAGGGAGGSGAGLSGP--AVFTSSFLVRFRRGVDNSFAHDVADKYGFDN 68
            |..|...|||:.|....||.| |..|.|..||  ||...|.............|..:|...|..|
Human    22 WLELAGLFLLVPWVMGLAGTG-GPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVN 85

  Fly    69 LGPLVGADGHEYHF----KHRTLPHARSRRSLTHTRALKSHPAVHTAVQQPGFKRVKRGLRPAVP 129
            .|.:....|| |.|    .||......:.|..... .|..|.||....:|...:|.||
Human    86 AGRIGELQGH-YLFVQPAGHRPALEVEAIRQQVEA-VLAGHEAVRWHSEQRLLRRAKR------- 141

  Fly   130 AIHGMKFDLKVGEGNRIDEEPTDPYFPMQWYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTAI 194
            ::|   |:              ||.:|.||:|.|....|    .|:||...|.:.:||:.||..:
Human   142 SVH---FN--------------DPKYPQQWHLNNRRSPG----RDINVTGVWERNVTGRGVTVVV 185

  Fly   195 MDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVA 259
            :||||::...|:..||:.|.|||.:||||.|.|....:..|.||||||||:||..:|..|.||||
Human   186 VDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVA 250

  Fly   260 YDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNE 324
            |.|:|||||:||.| :||.:||.:.........|||.||||.|||||||||......|:..||..
Human   251 YGSRIAGIRVLDGP-LTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIA 314

  Fly   325 GRNGLGNIYVWASGDGGE-EDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGA 388
            ||.|.|:|:|.|||:||: .|:||.||||.|::|::|.:...:|:...|.|.|:|.||.|||.|.
Human   315 GRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGD 379

  Fly   389 KDPNTGVATTDLYGK----CTTTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRNS 449
            |...: :.|||...:    ||..|:|||||||.|||:.||.|:..|.|||||:||:.|.|:.|..
Human   380 KMLRS-IVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYE 443

  Fly   450 LFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSVPPRYHCEAGELTQPQAIVMG-R 513
                ..|..|..|..|...:|..|||:|:|..:|..:|.|.|||......:..|.:.:||... |
Human   444 ----DRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPR 504

  Fly   514 SL--FWEIKTDACKGTDTEVN---YLEHVQAVISANASRRGDLELFLTSPMGTKSMILSRRANDD 573
            ||  .|.:..     .|.|::   .||||...:|....|||.|||.|..|.|..|:|.:.|:.|.
Human   505 SLEVLWNVSR-----MDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDS 564

  Fly   574 DHRDGFTKWPFMTTHSWGEYPQGTWKLEAR-FNSPQTRHGNLLEWSLVLHGT 624
            | .:||..|.|.|...|||..:||::|..| ......:.|.|.:|.|.|:|:
Human   565 D-PNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGS 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	19/82 (23%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	145/300 (48%)
		Peptidase_S8	187..459	CDD:278510	134/276 (49%)
		Peptidases_S8_S53	<409..485	CDD:299169	35/75 (47%)
		P_proprotein	534..621	CDD:279782	35/87 (40%)
PCSK7	NP_004707.2	S8_pro-domain	53..141	CDD:293079	21/89 (24%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	145..440	CDD:173789	146/314 (46%)
		Peptidase_S8	196..441	CDD:278510	125/246 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..219		11/21 (52%)
		P_proprotein	525..612	CDD:279782	35/87 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..751
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R643
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850