DRSC/TRiP Functional Genomics Resources

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Protein Alignment amon and PCSK7

DIOPT Version :10

Sequence 1:NP_477318.1 Gene:amon / 43215 FlyBaseID:FBgn0023179 Length:654 Species:Drosophila melanogaster
Sequence 2:NP_004707.2 Gene:PCSK7 / 9159 HGNCID:8748 Length:785 Species:Homo sapiens


Alignment Length:637 Identity:247/637 - (38%)
Similarity:323/637 - (50%) Gaps:61/637 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 WSWLLAPFLLLHWASAGAGGGAGGSGAGLSGP--AVFTSSFLVRFRRGVDNSFAHDVADKYGFDN 68
            |..|...|||:.|....||.| |..|.|..||  ||...|.............|..:|...|..|
Human    22 WLELAGLFLLVPWVMGLAGTG-GPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVN 85

  Fly    69 LGPLVGADGHEYHF----KHRTLPHARSRRSLTHTRALKSHPAVHTAVQQPGFKRVKRGLRPAVP 129
            .|.:....|| |.|    .||......:.|..... .|..|.||....:|...:|.||       
Human    86 AGRIGELQGH-YLFVQPAGHRPALEVEAIRQQVEA-VLAGHEAVRWHSEQRLLRRAKR------- 141

  Fly   130 AIHGMKFDLKVGEGNRIDEEPTDPYFPMQWYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTAI 194
            ::|   |:              ||.:|.||:|.|....|    .|:||...|.:.:||:.||..:
Human   142 SVH---FN--------------DPKYPQQWHLNNRRSPG----RDINVTGVWERNVTGRGVTVVV 185

  Fly   195 MDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVA 259
            :||||::...|:..||:.|.|||.:||||.|.|....:..|.||||||||:||..:|..|.||||
Human   186 VDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVA 250

  Fly   260 YDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNE 324
            |.|:|||||:||.| :||.:||.:.........|||.||||.|||||||||......|:..||..
Human   251 YGSRIAGIRVLDGP-LTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIA 314

  Fly   325 GRNGLGNIYVWASGDGGE-EDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGA 388
            ||.|.|:|:|.|||:||: .|:||.||||.|::|::|.:...:|:...|.|.|:|.||.|||.|.
Human   315 GRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGD 379

  Fly   389 KDPNTGVATTDLYGK----CTTTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRNS 449
            |...: :.|||...:    ||..|:|||||||.|||:.||.|:..|.|||||:||:.|.|:.|..
Human   380 KMLRS-IVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYE 443

  Fly   450 LFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSVPPRYHCEAGELTQPQAIVMG-R 513
                ..|..|..|..|...:|..|||:|:|..:|..:|.|.|||......:..|.:.:||... |
Human   444 ----DRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPR 504

  Fly   514 SL--FWEIKTDACKGTDTEVN---YLEHVQAVISANASRRGDLELFLTSPMGTKSMILSRRANDD 573
            ||  .|.:..     .|.|::   .||||...:|....|||.|||.|..|.|..|:|.:.|:.|.
Human   505 SLEVLWNVSR-----MDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDS 564

  Fly   574 DHRDGFTKWPFMTTHSWGEYPQGTWKLEAR-FNSPQTRHGNLLEWSLVLHGT 624
            | .:||..|.|.|...|||..:||::|..| ......:.|.|.:|.|.|:|:
Human   565 D-PNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGS 615

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
amonNP_477318.1 S8_pro-domain 43..122 CDD:465126 19/82 (23%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 150..446 CDD:173789 145/300 (48%)
Peptidases_S8_S53 <409..485 CDD:415849 35/75 (47%)
P_proprotein 534..621 CDD:460225 35/87 (40%)
PCSK7NP_004707.2 S8_pro-domain 53..141 CDD:465126 21/89 (24%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 145..440 CDD:173789 146/314 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 197..219 11/21 (52%)
P_proprotein 525..612 CDD:460225 35/87 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 700..751
Blue background indicates that the domain is not in the aligned region.

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