DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amon and MBTPS1

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_003782.1	Gene:	MBTPS1 / 8720	HGNCID:	15456	Length:	1052	Species:	Homo sapiens

Alignment Length:	628	Identity:	131/628 - (20%)
Similarity:	202/628 - (32%)	Gaps:	196/628 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 LKSHPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPMQWYLK---- 162
            |:.||.:.....|   ::|.|.|:.|                   :.:||.|....:|..|
Human   117 LEDHPNIKRVTPQ---RKVFRSLKYA-------------------ESDPTVPCNETRWSQKWQSS 159

  Fly   163 ----------------NTGQNGGK---------VRLDLNVQAAWAQGITGKNVTTAIMDDGVDYM 202
                            .||::..:         |...|.....|..|.||.||..|:.|.|:...
Human   160 RPLRRASLSLGSGFWHATGRHSSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEK 224

  Fly   203 HPDLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGI 267
            ||..|   |.:...::::.      |..||.. .|||..||.:|:.|:   | .|.|.|:::...
Human   225 HPHFK---NVKERTNWTNE------RTLDDGL-GHGTFVAGVIASMRE---C-QGFAPDAELHIF 275

  Fly   268 RMLDQ---PYMTDLIEANSMGHEPHKIHIYSASWGPTD--DGKTVDGPRNATMRAIVQGVNEGRN 327
            |:...   .|.:..::|.:.. ...||.:.:.|.|..|  |...||.....|...::.     .:
Human   276 RVFTNNQVSYTSWFLDAFNYA-ILKKIDVLNLSIGGPDFMDHPFVDKVWELTANNVIM-----VS 334

  Fly   328 GLGNIYVWASGDGGEEDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAKDPN 392
            .:||       ||......|  ..|..|..|.:.....:...|.:.....:|.......|...|:
Human   335 AIGN-------DGPLYGTLN--NPADQMDVIGVGGIDFEDNIARFSSRGMTTWELPGGYGRMKPD 390

  Fly   393 -----TGVATTDLYGKCTTTHSGTSAAAPEAAGVFALALE-------ANPQLTWRDIQHLTVLTS 445
                 .||..:.:.|.|... ||||.|:|..||...|.:.       .||             .|
Human   391 IVTYGAGVRGSGVKGGCRAL-SGTSVASPVVAGAVTLLVSTVQKRELVNP-------------AS 441

  Fly   446 KRNSLFDAKNRFHWTMNGVGLEFNHLFGFGVLD---AGAMVTLSKQWHSVPPRYHCEAGELTQ-- 505
            .:.:|..:..|    :.||.: |..  |.|.||   |..::...|...|:.|.|.    :||:
Human   442 MKQALIASARR----LPGVNM-FEQ--GHGKLDLLRAYQILNSYKPQASLSPSYI----DLTECP 495

  Fly   506 ------PQAIVMGRSLFWEIKTDACKGTDTEVNYLEHVQAVISANASRRGDLELFLTSPMGTKSM 564
                  .|.|..|             |..|.||                    :.:.:.||....
Human   496 YMWPYCSQPIYYG-------------GMPTVVN--------------------VTILNGMGVTGR 527

  Fly   565 ILSR-------RANDDDHRDGFT----KWPF-----------MTTHSWGEYPQGTWKLEARFNSP 607
            |:.:       ..|.|:....|:    .||:           ....||....||...:...  ||
Human   528 IVDKPDWQPYLPQNGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMITVA--SP 590

  Fly   608 -QTRHGNLLEWSLVLHGTKEAPYRT-LHPSSPHSKLAIVKKAH 648
             :|...|..|.:    .|.:.|.:. :.|:.|.||..:..:.|
Human   591 AETESKNGAEQT----STVKLPIKVKIIPTPPRSKRVLWDQYH 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	5/19 (26%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	75/341 (22%)
		Peptidase_S8	187..459	CDD:278510	66/288 (23%)
		Peptidases_S8_S53	<409..485	CDD:299169	22/85 (26%)
		P_proprotein	534..621	CDD:279782	17/109 (16%)
MBTPS1	NP_003782.1	Peptidases_S8_SKI-1_like	203..455	CDD:173805	69/298 (23%)
		Peptidase_S8	209..464	CDD:278510	70/304 (23%)
		DUF4350	651..724	CDD:290957
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	877..899
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1027..1052
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810