DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amon and KEX2

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_014161.1	Gene:	KEX2 / 855483	SGDID:	S000005182	Length:	814	Species:	Saccharomyces cerevisiae

Alignment Length:	491	Identity:	188/491 - (38%)
Similarity:	277/491 - (56%)	Gaps:	52/491 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 DPYFPMQWYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASY 216
            ||.|..||:|.|....|.    |:||...|...|||..|..||:|||:||.:.|||.|:.||.|:
Yeast   135 DPLFERQWHLVNPSFPGS----DINVLDLWYNNITGAGVVAAIVDDGLDYENEDLKDNFCAEGSW 195

  Fly   217 DFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEA 281
            ||:.|...|.||.:||:   ||||||||:||.:.|..|||||.|::||:|||:|.....|: .||
Yeast   196 DFNDNTNLPKPRLSDDY---HGTRCAGEIAAKKGNNFCGVGVGYNAKISGIRILSGDITTE-DEA 256

  Fly   282 NSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGEE-DD 345
            .|:.:......|||.||||.|||:.:.||.:...:|:|:||.|||:..|.|||:|||:||.. |:
Yeast   257 ASLIYGLDVNDIYSCSWGPADDGRHLQGPSDLVKKALVKGVTEGRDSKGAIYVFASGNGGTRGDN 321

  Fly   346 CNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAKDPNTGVATTDLYGKCTTTHSG 410
            ||.|||..|:::|:|.:..:...:..|.|.||:.:|.|:|:|:.:   .:.::|:.|:|:.:|.|
Yeast   322 CNYDGYTNSIYSITIGAIDHKDLHPPYSEGCSAVMAVTYSSGSGE---YIHSSDINGRCSNSHGG 383

  Fly   411 TSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTS---KRNSLFDAKNRFHWTMNGVGLEFNHLF 472
            ||||||.||||:.|.|||||.|||||:|:|::|::   ::|:..|      |..:.:|.:::|.:
Yeast   384 TSAAAPLAAGVYTLLLEANPNLTWRDVQYLSILSAVGLEKNADGD------WRDSAMGKKYSHRY 442

  Fly   473 GFGVLDAGAMVTLSKQWHSV--------PPRYHCEAGELTQPQ----AIVMGRSLFWEIKTDACK 525
            |||.:||..::.:||.|.:|        |..|..::...|:..    ..:..:||
Yeast   443 GFGKIDAHKLIEMSKTWENVNAQTWFYLPTLYVSQSTNSTEETLESVITISEKSL---------- 497

  Fly   526 GTDTEVNYLEHVQAVISANASRRGDLELFLTSPMGTKSMILSRRANDDDHRDGFTKWPFMTTHSW 590
             .|.....:|||...:..:...||...:.|.||.|..|.:...|..|.. .:||..|.||:...|
Yeast   498 -QDANFKRIEHVTVTVDIDTEIRGTTTVDLISPAGIISNLGVVRPRDVS-SEGFKDWTFMSVAHW 560

  Fly   591 GEYPQGTWKLEARFNSPQTRHGNLLE---WSLVLHG 623
            ||...|.||::.:    .|.:|:.::   |.|.|.|
Yeast   561 GENGVGDWKIKVK----TTENGHRIDFHSWRLKLFG 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	139/297 (47%)
		Peptidase_S8	187..459	CDD:278510	127/275 (46%)
		Peptidases_S8_S53	<409..485	CDD:299169	35/78 (45%)
		P_proprotein	534..621	CDD:279782	27/89 (30%)
KEX2	NP_014161.1	Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	133..419	CDD:173789	139/294 (47%)
KEX2	NP_014161.1	COG4935	463..653	CDD:227271	35/146 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I284
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I446
Isobase	1	0.950	-	0	Normalized mean entropy	S1029
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	1	1.000	-	-		otm46475
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R643
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.940