DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amon and YSP3

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_014645.1	Gene:	YSP3 / 854164	SGDID:	S000005529	Length:	478	Species:	Saccharomyces cerevisiae

Alignment Length:	452	Identity:	91/452 - (20%)
Similarity:	162/452 - (35%)	Gaps:	118/452 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LVRFRRGVDNSFAHDVADKYGFDNLGPLVGADGHEYHFKHRTLPHARS----------------R 93
            :|||...:|.:.:....:..|..:.|        .:|.:|:.:.|...                :
Yeast    26 IVRFIENIDGTRSVRAGEGLGQHDPG--------NFHTEHQHVAHKTEFLPYRYVIVFNEDISLQ 82

  Fly    94 RSLTHTRAL-KSH-PAVHTAVQQPGFKRVKRGLRPAVPAIHGMK--FD----------------L 138
            :..:|.:.: |.| .:|....:...|.||......:.....|:.  ||                :
Yeast    83 QIQSHMQVVQKDHSTSVGKLTENDAFWRVISSSVSSKSQFGGIDNFFDINGLFRGYTGYFTDEII 147

  Fly   139 KVGEGNRIDEEPTDPYFPMQWYLKNTGQNGGKVRLDLNVQAAWA--------------------Q 183
            |:     |.::|...:...:..:|.:..:       |..:|.|.                    :
Yeast   148 KI-----ISQDPIIKFVEQETTVKISNSS-------LQEEAPWGLHRVSHREKPKYGQDLEYLYE 200

  Fly   184 GITGKNVTTAIMDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAA 248
            ...||.||:.::|.|:|..|.|  |...||......:||.      ..| .|.|||.|||.:.:.
Yeast   201 DAAGKGVTSYVLDTGIDTEHED--FEGRAEWGAVIPANDE------ASD-LNGHGTHCAGIIGSK 256

  Fly   249 RDNGICGVGVAYDSKIAGIRML---DQPYMTDLIEANSMGHE-PHKIHIYSAS------WGPTDD 303
            .      .|||.::||..:::|   .:..::|:|:    |.| ..|.||.|:.      .|.|.:
Yeast   257 H------FGVAKNTKIVAVKVLRSNGEGTVSDVIK----GIEYVTKEHIESSKKKNKEFKGSTAN 311

  Fly   304 GKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGEEDDCNCDGYAASMWTISINSAINDGQ 368
            .........|...|:...|:.|.:       :|...|.|::|......|.:..:|::.::.....
Yeast   312 LSLGSSKSLAMEMAVNAAVDSGVH-------FAIAAGNEDEDACLSSPAGAEKSITVGASTFSDD 369

  Fly   369 NAHYDESCSSTLASTFSNGAKDPNTGVATTDLYGKCTTTHSGTSAAAPEAAGVFALALEANP 430
            .|.:  |...|....|:.|....:|.:.:.:    .|.:.||||.|:|..||:.:..|...|
Yeast   370 RAFF--SNWGTCVDVFAPGINIMSTYIGSRN----ATLSLSGTSMASPHVAGILSYFLSLQP 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	16/94 (17%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	70/311 (23%)
		Peptidase_S8	187..459	CDD:278510	65/254 (26%)
		Peptidases_S8_S53	<409..485	CDD:299169	10/22 (45%)
		P_proprotein	534..621	CDD:279782
YSP3	NP_014645.1	Inhibitor_I9	70..167	CDD:283552	13/101 (13%)
		AprE	79..>434	CDD:224322	82/391 (21%)
		Peptidases_S8_PCSK9_ProteinaseK_like	178..451	CDD:173790	66/280 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342043
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740