DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amon and Tpp2

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_006244914.2	Gene:	Tpp2 / 81815	RGDID:	621584	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	756	Identity:	150/756 - (19%)
Similarity:	236/756 - (31%)	Gaps:	292/756 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GSGAGLSG-----PAVFTSSFLVRFRRGVDNSFAHDVADKY--GFDNLGPLVGADGHEYHFKHRT 86
            |...||||     ||.:|:.                 :.||  |..|        |::::
  Rat    87 GEITGLSGRVLKIPANWTNP-----------------SGKYHIGIKN--------GYDFY----- 121

  Fly    87 LPHARSRRSLTHTRALKSHPAVHTAV------QQPGF-----------KRVKRGLRPAVPAIHGM 134
             |.|...| :...|..|....:|...      :|..|           |.:|..|:..|..:
  Rat   122 -PKALKER-IQKERKEKIWDPIHRVALAEACRKQEEFDIANNGSSQANKLIKEELQSQVELL--- 181

  Fly   135 KFDLKVGEGNRIDEEPTDP---YFPMQWY-------LKNTGQNG--GKVRLDLNVQAAWAQGITG 187
                     |..:::.:||   |..:.|:       ..::.:||  ||..:..|.:.|...|..|
  Rat   182 ---------NSFEKKYSDPGPVYDCLVWHDGETWRACVDSNENGDLGKSTVLRNYKEAQEYGSFG 237

  Fly   188 K----NVTTAIMDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAA 248
            .    |.:..|.|||          |..:..:..                 .:|||..| .:||.
  Rat   238 TAEMLNYSVNIYDDG----------NLLSIVTSG-----------------GAHGTHVA-SIAAG 274

  Fly   249 ------RDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEA-----NSMGHEPHKIHIYSASWGPTD 302
                  ..||:.........||...|:......|.||.|     |      ||..:.:.|:
  Rat   275 HFPEEPERNGVAPGAQILSIKIGDTRLSTMETGTGLIRAMIEVIN------HKCDLVNYSY---- 329

  Fly   303 DGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGEEDDC----NCDGYAASMWTISINSA 363
             |:....|.:.   .|.:.:||.......|||.::|:.|   .|    .|.|...|. .|.:.:.
  Rat   330 -GEATHWPNSG---RICEVINEAVWKHNTIYVSSAGNNG---PCLSTVGCPGGTTSS-VIGVGAY 386

  Fly   364 IN-DGQNAHYD--ESCSSTLASTFSNG-AKDPNTGVATTDLYG----------KCTTTHSGTSAA 414
            :: |...|.|.  |...:...:..|.| :.|...||:.:...|          :.|...:|||.:
  Rat   387 VSPDMMVAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVPNWTLRGTQLMNGTSMS 451

  Fly   415 APEAAGVFALALEA----NPQLTWRDIQ-------------------HLTVLTSK------RNSL 450
            :|.|.|..||.|..    |...|...::                   |..:...|      :|:.
  Rat   452 SPNACGGIALVLSGLKANNVDYTVHSVRRALENTAIKADNIEVFAQGHGIIQVDKAYDYLIQNTS 516

  Fly   451 FDAKNRFHWTM---------------------NGVGLE--------------FN-HLFGFGVLDA 479
            |  .||..:|:                     :|||:|              |. ||
  Rat   517 F--ANRLGFTVTVGNNRGIYLRDPVQVAAPSDHGVGIEPVFPENTENSEKISFQLHL-------- 571

  Fly   480 GAMVTLSKQWHSVPPRYHCEAGELTQPQAIVMGRSLFWEIKTDACKGTDTEVNYLEHV-QAVISA 543
              .:|.:..|...|.  |.|          :|.:.....|:.|. :|....::|.|.. ..:.|.
  Rat   572 --ALTSNSSWVQCPS--HLE----------LMNQCRHINIRVDP-RGLREGLHYTEVCGYDIASP 621

  Fly   544 NASRRGDLELFLTSPMGTKSMILSRRANDDDHRD-GFTK---WPFMTTHSWGEYPQG-TW----- 598
            ||.     .||.. |:   :.:::.:.|:..|.| .||.   .|......:.|.|:| ||
  Rat   622 NAG-----PLFRV-PI---TAVIAAKVNESSHYDLAFTDVHFKPGQIRRHFVEVPEGATWAEVTV 677

  Fly   599 -----KLEARFNSPQTRHGNLLEWSLVLHG---TKEAPYRT 631
                 ::.|:|               |||.   .|:..||:
  Rat   678 CSCSSEVSAKF---------------VLHAVQLVKQRAYRS 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	14/97 (14%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	75/363 (21%)
		Peptidase_S8	187..459	CDD:278510	69/333 (21%)
		Peptidases_S8_S53	<409..485	CDD:299169	25/140 (18%)
		P_proprotein	534..621	CDD:279782	20/102 (20%)
Tpp2	XP_006244914.2	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	14..489	CDD:173796	100/491 (20%)
Tpp2	XP_006244914.2	TPPII	777..963	CDD:403695
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900