DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amon and pcsk6

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_021333790.1	Gene:	pcsk6 / 794305	ZFINID:	ZDB-GENE-100908-1	Length:	869	Species:	Danio rerio

Alignment Length:	636	Identity:	232/636 - (36%)
Similarity:	322/636 - (50%)	Gaps:	114/636 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 AGLSGPAVFTSSFLVRFRRGVDNSFAHDVADKYGFDNLGPLVGADGHEYHFKHRTLPHARSRRSL 96
            |.||  .|:|:.:.||...|...  |.::|.||||.|||.:.|.: |.|||.||.:    .|||.
Zfish    41 ASLS--RVYTNHWAVRIPGGAGQ--ADELASKYGFTNLGQIGGLE-HHYHFHHRRV----VRRST 96

  Fly    97 THTRALKS----HPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPM 157
            ..||...|    .|.|..|.||....||||..|               .:.|.|..  .||.:..
Zfish    97 FATRGAHSFIHMDPKVVWAQQQVVKTRVKRHAR---------------SDSNHISF--NDPKWSN 144

  Fly   158 QWYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAE---ASYDFS 219
            .||                        |..:..|.:::     |:...|....:.|   |:.|..
Zfish   145 MWY------------------------IVSRYFTHSVL-----YVVSVLSLLIHLEITCATTDLI 180

  Fly   220 SNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEANSM 284
            .        :.|:.|                             :.|:||||.. :||::||.|:
Zfish   181 V--------FLDELF-----------------------------LQGVRMLDGD-VTDVVEAKSL 207

  Fly   285 GHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGEE-DDCNC 348
            |..|..:.||||||||.|||||||||.....:|...|..:||.|||:|:|||||:||.: |.|:|
Zfish   208 GIRPDYVDIYSASWGPDDDGKTVDGPGPLAKQAFELGSKKGRKGLGSIFVWASGNGGRQGDHCSC 272

  Fly   349 DGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAKDPNTGVATTDLYGKCTTTHSGTSA 413
            |||..|::||||:|:..:|....|.|.||||||:|:|:| :..:..:.||||..:||..|:|||.
Zfish   273 DGYTNSIYTISISSSTENGNKPWYLEVCSSTLATTYSSG-EFYDRKIVTTDLRQRCTDGHTGTSV 336

  Fly   414 AAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRNSLFDAKNRFHWTMNGVGLEFNHLFGFGVLD 478
            :||..|||.||||||||.:||||:|||.|.||::..|    ....|..|..|.:.:||:|||::|
Zfish   337 SAPMVAGVIALALEANPLITWRDVQHLLVKTSRQAHL----KANDWKTNAAGHKVSHLYGFGLVD 397

  Fly   479 AGAMVTLSKQWHSVPPRYHCEAGELTQPQAIVMGRSLFWEIKTDACKG-TDTEVNYLEHVQAVIS 542
            |.|||..:|:|.:||.::.|......:.:.|...:.|...|.::.|:. ::..|.:||||...:.
Zfish   398 AEAMVVEAKKWRNVPAQHICSKTSDRRTRYIRAEQKLNASISSNGCRDQSEQTVVFLEHVVVRVL 462

  Fly   543 ANASRRGDLELFLTSPMGTKSMILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSP 607
            ....||||||:.|.||.||:|.:|::|..|:.: :||..|.|||.|.|||..:|||.||...:..
Zfish   463 IVHPRRGDLEINLISPSGTRSQLLAQRLFDNSN-EGFRNWEFMTVHCWGEKAEGTWTLEISDSPS 526

  Fly   608 QTRH----GNLLEWSLVLHGTKEAPYRTLHPSSPHSKLAIVKKAHEDKKMK 654
            |.|:    |.|.||:|:||||.|.|.::  .||..|:...:......::||
Zfish   527 QLRNPEVLGKLKEWTLILHGTSEDPQQS--QSSQQSRSRTLDLPIAGREMK 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	32/82 (39%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	113/299 (38%)
		Peptidase_S8	187..459	CDD:278510	110/275 (40%)
		Peptidases_S8_S53	<409..485	CDD:299169	40/75 (53%)
		P_proprotein	534..621	CDD:279782	41/90 (46%)
pcsk6	XP_021333790.1	Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	35..369	CDD:173789	155/421 (37%)
		P_proprotein	454..544	CDD:307572	41/90 (46%)
		FU	594..763	CDD:320742
		FU	743..785	CDD:214589
		FU	795..829	CDD:214589
		PLAC	841..864	CDD:312271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920