DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amon and mbtps1

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001072791.2	Gene:	mbtps1 / 780252	XenbaseID:	XB-GENE-1016860	Length:	1061	Species:	Xenopus tropicalis

Alignment Length:	499	Identity:	111/499 - (22%)
Similarity:	163/499 - (32%)	Gaps:	144/499 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 HEYHFKHRTLPHARSRRSLTHTRALKS------------HPA-------------------VHTA 111
            |||.........|::|.....| ||||            :||                   |.|.
Frog    63 HEYIVAFTGYYTAKARNKFIST-ALKSRGISDWKIVPRNNPASDYPSDFELIEIKTSQRDTVLTL 126

  Fly   112 VQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPMQWYLK-------------- 162
            ...|..|||    .|.......:||         ::.|...|....:|..|
Frog   127 EDHPNIKRV----TPQRRVFRSLKF---------VESEMPAPCNETKWSQKWQSSRPLRRTSLSL 178

  Fly   163 ------NTGQNGGK---------VRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNA 212
                  .||::..:         |...|.....|..|.||.||..|:.|.|:...||..|   |.
Frog   179 SSGFWHATGRHSSRRLLKAIPRQVAQTLQADVLWQLGYTGSNVKVAVFDTGLSEKHPHFK---NV 240

  Fly   213 EASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQ---PY 274
            :...::::.      :..||.. .|||..||.:|:.|:   | .|.|.||::...|:...   .|
Frog   241 KERTNWTNE------KTLDDGL-GHGTFVAGVIASMRE---C-QGFAPDSELHIYRVFTNNQVSY 294

  Fly   275 MTDLIEANSMGHEPHKIHIYSASWGPTD--DGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWAS 337
            .:..::|.:.. ...||.:.:.|.|..|  |...||.....|...::.     .:.:||
Frog   295 TSWFLDAFNYA-ILKKIDVLNLSIGGPDFMDHPFVDKVWELTANNVIM-----VSAIGN------ 347

  Fly   338 GDGGEEDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAKDPN-----TGVAT 397
             ||......|  ..|..|..|.:.....:...|.:.....:|.......|...|:     :||..
Frog   348 -DGPLYGTLN--NPADQMDVIGVGGIDFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGSGVRG 409

  Fly   398 TDLYGKCTTTHSGTSAAAPEAAGVFALALE-------ANPQLTWRDIQHLTVLTSKRNSLFDAKN 455
            :.|.|.|.:. ||||.|:|..||...|.:.       .||             .|.:.:|..:..
Frog   410 SGLKGGCRSL-SGTSVASPVVAGAVTLLVSTVQKRELVNP-------------ASMKQALIASAR 460

  Fly   456 RFHWTMNGVGLEFNHLFGFGVLD---AGAMVTLSKQWHSVPPRY 496
            |    :.||.: |..  |.|.||   |..::...|...|:.|.|
Frog   461 R----LPGVNM-FEQ--GHGKLDLLRAFQILNSYKPQASLSPSY 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	18/74 (24%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	74/341 (22%)
		Peptidase_S8	187..459	CDD:278510	67/288 (23%)
		Peptidases_S8_S53	<409..485	CDD:299169	22/85 (26%)
		P_proprotein	534..621	CDD:279782
mbtps1	NP_001072791.2	Peptidases_S8_SKI-1_like	212..464	CDD:173805	70/298 (23%)
mbtps1	NP_001072791.2	DUF4350	660..733	CDD:379527
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910