DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amon and TPP2

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_005254127.1	Gene:	TPP2 / 7174	HGNCID:	12016	Length:	1304	Species:	Homo sapiens

Alignment Length:	743	Identity:	150/743 - (20%)
Similarity:	232/743 - (31%)	Gaps:	266/743 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GSGAGLSG-----PAVFTSSFLVRFRRGVDNSFAHDVADKY--GFDNLGPLVGADGHEYHFKHRT 86
            |...||||     ||.:|:.                 :.||  |..|        |::::
Human    87 GEIVGLSGRVLKIPASWTNP-----------------SGKYHIGIKN--------GYDFY----- 121

  Fly    87 LPHARSRRSLTHTRALKSHPAVHTAV------QQPGF-----------KRVKRGLRPAVPAIHGM 134
             |.|...| :...|..|....||...      :|..|           |.:|..|:..|..:
Human   122 -PKALKER-IQKERKEKIWDPVHRVALAEACRKQEEFDVANNGSSQANKLIKEELQSQVELL--- 181

  Fly   135 KFDLKVGEGNRIDEEPTDP---YFPMQWYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTAIMD 196
                     |..:::.:||   |..:.|:       .|:|         |...|...       :
Human   182 ---------NSFEKKYSDPGPVYDCLVWH-------DGEV---------WRACIDSN-------E 214

  Fly   197 DGVDYMHPDLKFNYNAEASY-DFSSNDPFPYPRYTDDWFN---------SHGTRCAGEVAAA--- 248
            || |.....:..||.....| .|.:.:...|.....|..|         :|||..| .:||.
Human   215 DG-DLSKSTVLRNYKEAQEYGSFGTAEMLNYSVNIYDDGNLLSIVTSGGAHGTHVA-SIAAGHFP 277

  Fly   249 ---RDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEA-----NSMGHEPHKIHIYSASWGPTDDGK 305
               ..||:.........||...|:......|.||.|     |      ||..:.:.|:     |:
Human   278 EEPERNGVAPGAQILSIKIGDTRLSTMETGTGLIRAMIEVIN------HKCDLVNYSY-----GE 331

  Fly   306 TVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGEEDDC----NCDGYAASMWTISINSAIN- 365
            ....|.:.   .|.:.:||.......|||.::|:.|   .|    .|.|...|. .|.:.:.::
Human   332 ATHWPNSG---RICEVINEAVWKHNIIYVSSAGNNG---PCLSTVGCPGGTTSS-VIGVGAYVSP 389

  Fly   366 DGQNAHYD--ESCSSTLASTFSNG-AKDPNTGVATTDLYG----------KCTTTHSGTSAAAPE 417
            |...|.|.  |...:...:..|.| :.|...||:.:...|          :.|...:|||.::|.
Human   390 DMMVAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVPNWTLRGTQLMNGTSMSSPN 454

  Fly   418 AAGVFALALEA----NPQLTWRDIQ-------------------HLTVLTSK------RNSLFDA 453
            |.|..||.|..    |...|...::                   |..:...|      :|:.|..
Human   455 ACGGIALILSGLKANNIDYTVHSVRRALENTAVKADNIEVFAQGHGIIQVDKAYDYLVQNTSFAN 519

  Fly   454 KNRFHWTM-------------------NGVGLEFNHLFGFGV-------LDAGAMVTLSKQWHSV 492
            |..|..|:                   :|||:|  .:|....       |.....:|.:..|...
Human   520 KLGFTVTVGNNRGIYLRDPVQVAAPSDHGVGIE--PVFPENTENSEKISLQLHLALTSNSSWVQC 582

  Fly   493 PPRYHCEAGELTQPQAIVMGRSLFWEIKTDACKGTDTEVNYLEHV-QAVISANASRRGDLELFLT 556
            |.  |.|          :|.:.....|:.|. :|....::|.|.. ..:.|.||.     .||..
Human   583 PS--HLE----------LMNQCRHINIRVDP-RGLREGLHYTEVCGYDIASPNAG-----PLFRV 629

  Fly   557 SPMGTKSMILSRRANDDDHRD-GFTK---WPFMTTHSWGEYPQG-TW----------KLEARFNS 606
             |:   :.:::.:.|:..|.| .||.   .|......:.|.|:| ||          ::.|:|
Human   630 -PI---TAVIAAKVNESSHYDLAFTDVHFKPGQIRRHFIEVPEGATWAEVTVCSCSSEVSAKF-- 688

  Fly   607 PQTRHGNLLEWSLVLHG---TKEAPYRT 631
                         |||.   .|:..||:
Human   689 -------------VLHAVQLVKQRAYRS 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	15/97 (15%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	75/360 (21%)
		Peptidase_S8	187..459	CDD:278510	72/339 (21%)
		Peptidases_S8_S53	<409..485	CDD:299169	24/130 (18%)
		P_proprotein	534..621	CDD:279782	20/102 (20%)
TPP2	XP_005254127.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	14..489	CDD:173796	101/488 (21%)
TPP2	XP_005254127.1	TPPII	777..960	CDD:378883
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900