DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amon and furinb

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001038574.2	Gene:	furinb / 566591	ZFINID:	ZDB-GENE-040901-2	Length:	823	Species:	Danio rerio

Alignment Length:	597	Identity:	277/597 - (46%)
Similarity:	366/597 - (61%)	Gaps:	53/597 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LSGPAVFTSSFLVRFRRGVDNSFAHDVADKYGFDNLGPLVGADGHEYHFKHRTLPHARSRRSLT- 97
            ::|..::.:::.|....||:.  |..:|.|:||.:.|.:.   |..|||:||.:    .||||:
Zfish    25 ITGQGIYINTWAVHIEGGVEE--AERIAQKHGFVSHGQVF---GDFYHFQHRGV----VRRSLSS 80

  Fly    98 ----HTRALKSHPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPMQ 158
                |.| |.:.|.|..|.||...:|.||.                      |..|||||.||.|
Zfish    81 HRGVHVR-LHTEPQVLWAEQQIAKRRRKRD----------------------IHMEPTDPKFPQQ 122

  Fly   159 WYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASYDFSSNDP 223
            |||.|....      ||||:.|||||.||:.|...|:|||::..||||..||:.:||||.:..||
Zfish   123 WYLYNPSHG------DLNVKEAWAQGFTGRGVVVTILDDGIEKDHPDLAKNYDPDASYDVNDRDP 181

  Fly   224 FPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEANSMGHEP 288
            .|.||||....|.||||||||||||.:||:|||||||::||.|:||||.. :||::||.|:....
Zfish   182 DPQPRYTQLNDNRHGTRCAGEVAAAANNGVCGVGVAYNAKIGGVRMLDGE-VTDVVEAQSLSLNS 245

  Fly   289 HKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGG-EEDDCNCDGYA 352
            ..||||||||||.|||||||||......|.:|||.|||:|||:|:|||||:|| |.|.||||||.
Zfish   246 QHIHIYSASWGPEDDGKTVDGPAKLAKEAFLQGVTEGRSGLGSIFVWASGNGGRERDSCNCDGYT 310

  Fly   353 ASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAKDPNTGVATTDLYGKCTTTHSGTSAAAPE 417
            .|::|:||:|....|....|.|:||||||:|:|:|..:... :.||||..|||.:|:||||:||.
Zfish   311 NSIYTLSISSTTQYGSVPWYSEACSSTLATTYSSGNLNEKQ-IVTTDLRKKCTDSHTGTSASAPL 374

  Fly   418 AAGVFALALEANPQLTWRDIQHLTVLTSKRNSLFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAM 482
            |||:.|||||||..|||||:|||.|.||:...|...    .|..||||...:|.:|:|:|||.||
Zfish   375 AAGIIALALEANMNLTWRDMQHLVVRTSRPAHLITN----DWRTNGVGRLVSHSYGYGLLDATAM 435

  Fly   483 VTLSKQWHSVPPRYHCEAGELTQPQAIVMGRSLFWEIKTDACKGTDTEVNYLEHVQAVISANASR 547
            |.|::.|.|:.|::.|....||:|:.|  ...|.:....:||.|....|:.||||||.::.:.:.
Zfish   436 VALAQNWTSMGPQHKCVINMLTEPRDI--KNHLTFSRSVEACSGQPDFVSSLEHVQARLTLSYNH 498

  Fly   548 RGDLELFLTSPMGTKSMILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRHG 612
            ||:|.:.|.||:||:|.:|:.|..|:. .:||..|.|||||||.|.|:|.|.||....:....:|
Zfish   499 RGNLAVHLISPLGTRSTLLAPRPQDNS-AEGFNDWAFMTTHSWDEDPRGEWTLEIENVAGLNDYG 562

  Fly   613 NLLEWSLVLHGT 624
            .|.:::|:|:||
Zfish   563 VLSQFTLILYGT 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	28/83 (34%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	174/296 (59%)
		Peptidase_S8	187..459	CDD:278510	155/272 (57%)
		Peptidases_S8_S53	<409..485	CDD:299169	42/75 (56%)
		P_proprotein	534..621	CDD:279782	37/86 (43%)
furinb	NP_001038574.2	S8_pro-domain	34..108	CDD:293079	28/83 (34%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	114..403	CDD:173789	174/296 (59%)
		Peptidase_S8	145..428	CDD:278510	162/288 (56%)
		P_proprotein	485..571	CDD:279782	37/86 (43%)
		TNFRSF	606..>669	CDD:304602
		FU	648..683	CDD:214589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I12000
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R643
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850