DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amon and fras1

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_005165392.1	Gene:	fras1 / 563428	ZFINID:	ZDB-GENE-060526-68	Length:	4003	Species:	Danio rerio

Alignment Length:	630	Identity:	120/630 - (19%)
Similarity:	203/630 - (32%)	Gaps:	232/630 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 RVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPMQWYLKNTGQNGGKVRL------DLNV 177
            |.|.|  |.|....|::  |..|..::|.|:          :||.|..:...::|      ||:|
Zfish  2071 RKKEG--PRVTINRGLQ--LAAGSSSKITEQ----------HLKGTDIDSDNLKLRFTLIKDLSV 2121

  Fly   178 QAAWAQGITGKN---------VTTAIMDD----GVDYMHPDLKFNYNAEASYDFSSNDPFPYPRY 229
            .:...:  ||:|         ||:...||    .|:|:|.  |.......|:.|:..||
Zfish  2122 GSLMLK--TGRNKARVSVKGPVTSFTQDDINKGHVEYIHE--KGESGGSFSFKFNLEDP------ 2176

  Fly   230 TDDWFNSHGTRCAGE---VAAARD----NGICGVGVAYD----SKIAGI---------------- 267
                   .|.|...:   ::...|    ..:...|:..|    .||..:
Zfish  2177 -------EGNRVIDQSFFISVLEDRLPPTVVVNKGLVLDENSLKKITTLQLSSTDQDSEPDELVY 2234

  Fly   268 RMLDQPYMTDLIEANSMG-------------------H-EPHKIHIYSASWGPTDDGKTVDGPRN 312
            |:..||.:..|..:|..|                   | ...:||....::..:|.|..|.....
Zfish  2235 RITKQPQLGHLEHSNKPGTRISSFTQADLASRSIQYVHTSEDEIHSDDFTFTVSDGGNEVSQTFY 2299

  Fly   313 ATMRAI--------VQG--VNEG-RNGLGNIYVWASGDGGEEDDCNCDGYAASMWTISINSAIND 366
            .|:|.:        |.|  |.|| |..:....:.|:....|||..          |.:|..|...
Zfish  2300 ITIRPVDDALPVLQVPGMRVQEGVRKTITEFELKATDADTEEDSV----------TFTIVQAPRH 2354

  Fly   367 G------QNAHYDESCSSTLASTF----------SNGAKDPNT---GVATTDLY-----GKCTTT 407
            |      ...||.::.:.|:...:          ||..||..|   |..|...:     ||...|
Zfish  2355 GTIERTSNGQHYRQTNTFTMDDVYQNRISYNHDGSNSLKDRFTFTVGDGTNMFFIIEEGGKEVVT 2419

  Fly   408 HSGTSAAAPEAAGVFALAL-EANPQL-TWRDIQHLTVLTSKRNSLFDAKNRFHWTMNGVGLEFNH 470
                  |||:...:..|.: :..|:: |...:|.|..:.:|..:|...|..|
Zfish  2420 ------AAPQKFKIDILPVDDGTPRIVTNLGLQWLEYMENKATNLISKKELF------------- 2465

  Fly   471 LFGFGVLDAGAMVTLSKQWHSVPPRYHCEAGELTQPQAIVMGRSLFWEIKTDACKG-TDTEVNYL 534
                                ::.|  ..:.|:||            :||.|:|..| .::::|..
Zfish  2466 --------------------TIDP--DTDDGQLT------------YEITTEAKHGYLESKLNPG 2496

  Fly   535 EHVQAVISANASRRGDLELFLTSPMGTKSMILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGT-- 597
            :.:.:...|:.:            :|....:||    :|:.::....:.|:...|........
Zfish  2497 KPITSFTQADIN------------LGLIRYVLS----EDNVQETMDNFKFLVKDSKPNIVSDNVF 2545

  Fly   598 ---WKL----EARFNSPQ---------TRHGNLLEWSLVLHGTKE 626
               |.|    ...||..:         .|.|||.::::||..|::
Zfish  2546 HIQWSLISFEHKSFNVSEKDGTVAVTVKRTGNLNQYAIVLCRTEQ 2590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	1/2 (50%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	78/398 (20%)
		Peptidase_S8	187..459	CDD:278510	74/368 (20%)
		Peptidases_S8_S53	<409..485	CDD:299169	12/77 (16%)
		P_proprotein	534..621	CDD:279782	15/104 (14%)
fras1	XP_005165392.1	VWC	26..85	CDD:278520
		VWC	93..150	CDD:278520
		VWC	157..214	CDD:278520
		VWC	219..276	CDD:278520
		VWC	283..340	CDD:278520
		VWC	364..414	CDD:302663
		FU	419..465	CDD:238021
		Furin-like_2	424..512	CDD:292535
		FU	461..503	CDD:214589
		FU	507..551	CDD:214589
		GF_recep_IV	512..669	CDD:291509
		FU	555..597	CDD:214589
		Furin-like	588..762	CDD:279142
		FU	602..645	CDD:214589
		FU	648..700	CDD:214589
		FU	704..748	CDD:214589
		Furin-like	737..911	CDD:279142
		FU	754..796	CDD:214589
		FU	855..897	CDD:214589
		Furin-like	888..1054	CDD:279142
		FU	950..994	CDD:214589
		FU	1044..1086	CDD:214589
		Cadherin_3	<1097..1196	CDD:292802
		Cadherin_3	1166..1306	CDD:292802
		Cadherin_3	1406..1538	CDD:292802
		Cadherin_3	1526..1689	CDD:292802
		Cadherin_3	1658..1811	CDD:292802
		Cadherin_3	1777..1934	CDD:292802
		Cadherin_3	1901..2056	CDD:292802
		Cadherin_3	2025..2175	CDD:292802	30/121 (25%)
		Cadherin_3	2144..2290	CDD:292802	26/160 (16%)
		Cadherin_3	2258..2403	CDD:292802	31/154 (20%)
		Cadherin_3	2372..2534	CDD:292802	39/230 (17%)
		Calx-beta	2550..2647	CDD:295344	10/41 (24%)
		Calx-beta	2672..2771	CDD:295344
		Calx-beta	2795..2891	CDD:295344
		Calx-beta	2917..3008	CDD:295344
		Calx-beta	3036..3130	CDD:295344
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810