DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amon and PCSK4

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_011526387.1	Gene:	PCSK4 / 54760	HGNCID:	8746	Length:	782	Species:	Homo sapiens

Alignment Length:	658	Identity:	270/658 - (41%)
Similarity:	375/658 - (56%)	Gaps:	72/658 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ATWSWLLAPFLLLH-----WASAGAGGGAGGSGAGLSGPAVFTSSFLVRFRRGVDNSFAHDVADK 63
            |.|..|:....|:.     ||...|              .::.||:.|:..:|  |.....:|.|
Human     7 ALWLRLVLALALVRPRAVGWAPVRA--------------PIYVSSWAVQVSQG--NREVERLARK 55

  Fly    64 YGFDNLGPLVGADGHEYHFKHRTLPHARSRRSLT----HTRALKSHPAVH---TAVQQPGFKRVK 121
            :||.||||:. .||..:|.:||.:    .::|||    |...||.:|...   .::||....|.:
Human    56 FGFVNLGPIF-PDGQYFHLRHRGV----VQQSLTPHWGHRLHLKKNPKTRPGPKSIQQEEAGRPR 115

  Fly   122 RGLRPAVPAI----------HGMKFDLKVGEGNRIDEEPTDPYFPMQWYLKNTGQNGGKVRLDLN 176
            .|...|...:          ..:|..:.|         ||||:|..|||:.:..|.      ||:
Human   116 YGNHGACQGLVQWFQQQTLQRRVKRSVVV---------PTDPWFSKQWYMNSEAQP------DLS 165

  Fly   177 VQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRC 241
            :..||:||::|:.:..:::|||::..||||..||:..|||||:..||.|.||||....|.|||||
Human   166 ILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPSKENRHGTRC 230

  Fly   242 AGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASWGPTDDGKT 306
            ||||||..:||.||||||::::|.|:||||.. :||:|||.|:..:|..||||||||||.|||:|
Human   231 AGEVAAMANNGFCGVGVAFNARIGGVRMLDGT-ITDVIEAQSLSLQPQHIHIYSASWGPEDDGRT 294

  Fly   307 VDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGG-EEDDCNCDGYAASMWTISINSAINDGQNA 370
            ||||...|..|..:||.:||.|||.:::||||:|| ..|:||||||..|:.|:|:.|....|:..
Human   295 VDGPGILTREAFRRGVTKGRGGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVP 359

  Fly   371 HYDESCSSTLASTFSNG-AKDPNTGVATTDLYGKCTTTHSGTSAAAPEAAGVFALALEANPQLTW 434
            .|.|:|:|||.:|:|:| |.||.  :.||||:..||..|:||||:||.|||:.||||||||.|||
Human   360 WYSEACASTLTTTYSSGVATDPQ--IVTTDLHHGCTDQHTGTSASAPLAAGMIALALEANPFLTW 422

  Fly   435 RDIQHLTVLTSKRNSLFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSVPPRYHCE 499
            ||:|||.|..||...| .|::   |..||||.:.:|.:|:|:||||.:|..::.|....|:..|.
Human   423 RDMQHLVVRASKPAHL-QAED---WRTNGVGRQVSHHYGYGLLDAGLLVDTARTWLPTQPQRKCA 483

  Fly   500 AGELTQPQAIVMGRSLFWEIKTDACKGTDTEVNYLEHVQAVISANASRRGDLELFLTSPMGTKSM 564
            ....::|..|:  ..::......||.|....:..||||||.::.:.|||||||:.|||||||:|.
Human   484 VRVQSRPTPIL--PLIYIRENVSACAGLHNSIRSLEHVQAQLTLSYSRRGDLEISLTSPMGTRST 546

  Fly   565 ILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRHGNLLEWSLVLHGTKEAPY 629
            :::.|..|.. .:|:..|.||:||.|.|.|||.|.|...........|.|..::|:|:||.|.
Human   547 LVAIRPLDVS-TEGYNNWVFMSTHFWDENPQGVWTLGLENKGYYFNTGTLYRYTLLLYGTAED-- 608

  Fly   630 RTLHPSSP 637
            .|..|:.|
Human   609 MTARPTGP 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	27/85 (32%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	160/297 (54%)
		Peptidase_S8	187..459	CDD:278510	149/273 (55%)
		Peptidases_S8_S53	<409..485	CDD:299169	43/75 (57%)
		P_proprotein	534..621	CDD:279782	39/86 (45%)
PCSK4	XP_011526387.1	S8_pro-domain	37..140	CDD:293079	29/109 (27%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	145..434	CDD:173789	160/297 (54%)
		Peptidase_S8	176..459	CDD:278510	156/289 (54%)
		P_proprotein	516..602	CDD:279782	39/86 (45%)
		FU	674..711	CDD:214589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820