Protein Alignment amon and PCSK2

DIOPT Version :10

• Sequence 1: NP_477318.1
• Gene: amon / 43215
• FlyBaseID: FBgn0023179
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_002585.2
• Gene: PCSK2 / 5126
• HGNCID: 8744
• Length: 638
• Species: Homo sapiens
• Alignment Length: 616
• Identity: 384/616 - (62%)
• Similarity: 448/616 - (72%)
• Gaps: 22/616 - (3%)

  Fly    39 VFTSSFLVRFRRGVDNSFAHDVADKYGFDNLGPLVGADGHEYHFKHRTLPHARSRRSLTHTRALK 103
            |||:.|||...:|.::. |..||.::|| .:..|..|:| .|||.|..|..|:.||||.|.:.|:
Human    29 VFTNHFLVELHKGGEDK-ARQVAAEHGF-GVRKLPFAEG-LYHFYHNGLAKAKRRRSLHHKQQLE 90

  Fly   104 SHPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPMQWYLKNTGQNG 168
            ..|.|..|:||.||.|.|||.|           |:     |.||....||.|..||||.||||..
Human    91 RDPRVKMALQQEGFDRKKRGYR-----------DI-----NEIDINMNDPLFTKQWYLINTGQAD 139

  Fly   169 GKVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDW 233
            |...|||||..||..|.|||.||..|||||:||:||||..|||||||||||||||:|||||||||
Human   140 GTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDW 204

  Fly   234 FNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASW 298
            ||||||||||||:||.:|.||||||||:||:|||||||||:|||:|||:|:.|.|..|.||||||
Human   205 FNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASW 269

  Fly   299 GPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGEEDDCNCDGYAASMWTISINSA 363
            ||||:||||||||..|::|:..|||:||.|.|:||||||||||..|||||||||:||||||||||
Human   270 GPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSA 334

  Fly   364 INDGQNAHYDESCSSTLASTFSNGAK-DPNTGVATTDLYGKCTTTHSGTSAAAPEAAGVFALALE 427
            ||||:.|.||||||||||||||||.| :|..|||||||||.||..||||||||||||||||||||
Human   335 INDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALE 399

  Fly   428 ANPQLTWRDIQHLTVLTSKRNSLFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSV 492
            ||..|||||:|||||||||||.|.|..::  |..||||||||||||:|||||||||.::|.|.:|
Human   400 ANLGLTWRDMQHLTVLTSKRNQLHDEVHQ--WRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTV 462

  Fly   493 PPRYHCEAGELTQPQAIVMGRSLFWEIKTDACKGTDTEVNYLEHVQAVISANASRRGDLELFLTS 557
            |.|:||..|.:..|:.|.....|...:.||||:|.:..|.|||||||||:.||:|||||.:.:||
Human   463 PERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTS 527

  Fly   558 PMGTKSMILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRHGNLLEWSLVLH 622
            ||||||::||||..|||.:.||.||||||||:|||..:|||.||..|.....:.|.|.||:|:||
Human   528 PMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLH 592

  Fly   623 GTKEAPYRTLHPSSPHSKLAIVKKAHEDKKM 653
            ||:.|||.........||||:.||...::::
Human   593 GTQSAPYIDQVVRDYQSKLAMSKKEELEEEL 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:465126	32/78 (41%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	150..446	CDD:173789	228/296 (77%)
		Peptidases_S8_S53	<409..485	CDD:415849	61/75 (81%)
		P_proprotein	534..621	CDD:460225	54/86 (63%)
PCSK2	NP_002585.2	S8_pro-domain	33..109	CDD:465126	32/78 (41%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	122..418	CDD:173789	228/295 (77%)
		P_proprotein	504..591	CDD:460225	54/86 (63%)