DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amon and PCSK2

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_002585.2	Gene:	PCSK2 / 5126	HGNCID:	8744	Length:	638	Species:	Homo sapiens

Alignment Length:	616	Identity:	384/616 - (62%)
Similarity:	448/616 - (72%)	Gaps:	22/616 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VFTSSFLVRFRRGVDNSFAHDVADKYGFDNLGPLVGADGHEYHFKHRTLPHARSRRSLTHTRALK 103
            |||:.|||...:|.::. |..||.::|| .:..|..|:| .|||.|..|..|:.||||.|.:.|:
Human    29 VFTNHFLVELHKGGEDK-ARQVAAEHGF-GVRKLPFAEG-LYHFYHNGLAKAKRRRSLHHKQQLE 90

  Fly   104 SHPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPMQWYLKNTGQNG 168
            ..|.|..|:||.||.|.|||.|           |:     |.||....||.|..||||.||||..
Human    91 RDPRVKMALQQEGFDRKKRGYR-----------DI-----NEIDINMNDPLFTKQWYLINTGQAD 139

  Fly   169 GKVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDW 233
            |...|||||..||..|.|||.||..|||||:||:||||..|||||||||||||||:|||||||||
Human   140 GTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDW 204

  Fly   234 FNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASW 298
            ||||||||||||:||.:|.||||||||:||:|||||||||:|||:|||:|:.|.|..|.||||||
Human   205 FNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASW 269

  Fly   299 GPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGEEDDCNCDGYAASMWTISINSA 363
            ||||:||||||||..|::|:..|||:||.|.|:||||||||||..|||||||||:||||||||||
Human   270 GPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSA 334

  Fly   364 INDGQNAHYDESCSSTLASTFSNGAK-DPNTGVATTDLYGKCTTTHSGTSAAAPEAAGVFALALE 427
            ||||:.|.||||||||||||||||.| :|..|||||||||.||..||||||||||||||||||||
Human   335 INDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALE 399

  Fly   428 ANPQLTWRDIQHLTVLTSKRNSLFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSV 492
            ||..|||||:|||||||||||.|.|..::  |..||||||||||||:|||||||||.::|.|.:|
Human   400 ANLGLTWRDMQHLTVLTSKRNQLHDEVHQ--WRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTV 462

  Fly   493 PPRYHCEAGELTQPQAIVMGRSLFWEIKTDACKGTDTEVNYLEHVQAVISANASRRGDLELFLTS 557
            |.|:||..|.:..|:.|.....|...:.||||:|.:..|.|||||||||:.||:|||||.:.:||
Human   463 PERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTS 527

  Fly   558 PMGTKSMILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRHGNLLEWSLVLH 622
            ||||||::||||..|||.:.||.||||||||:|||..:|||.||..|.....:.|.|.||:|:||
Human   528 PMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLH 592

  Fly   623 GTKEAPYRTLHPSSPHSKLAIVKKAHEDKKM 653
            ||:.|||.........||||:.||...::::
Human   593 GTQSAPYIDQVVRDYQSKLAMSKKEELEEEL 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	32/78 (41%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	228/296 (77%)
		Peptidase_S8	187..459	CDD:278510	213/272 (78%)
		Peptidases_S8_S53	<409..485	CDD:299169	61/75 (81%)
		P_proprotein	534..621	CDD:279782	54/86 (63%)
PCSK2	NP_002585.2	S8_pro-domain	33..109	CDD:293079	32/78 (41%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	122..418	CDD:173789	228/295 (77%)
		Peptidase_S8	158..435	CDD:278510	216/278 (78%)
		P_proprotein	504..591	CDD:279782	54/86 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151634
Domainoid	1	1.000	445	1.000	Domainoid score	I529
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37640
Inparanoid	1	1.050	753	1.000	Inparanoid score	I570
Isobase	1	0.950	-	0	Normalized mean entropy	S1029
OMA	1	1.010	-	-		QHG45838
OrthoDB	1	1.010	-	-		D308083at2759
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	1	1.000	-	-		oto90225
orthoMCL	1	0.900	-	-		OOG6_105550
Panther	1	1.100	-	-	LDO	PTHR42884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R643
SonicParanoid	1	1.000	-	-		X5187
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750