DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amon and PCSK1

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_000430.3	Gene:	PCSK1 / 5122	HGNCID:	8743	Length:	753	Species:	Homo sapiens

Alignment Length:	657	Identity:	272/657 - (41%)
Similarity:	364/657 - (55%)	Gaps:	76/657 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAATWSWLLAPFLLL-----------------HWASAGAGGGAGGSGAGLSGPAVFTSSFLVRF 48
            |....||.....|:|.                 .||:...||....|.
Human     1 MERRAWSLQCTAFVLFCAWCALNSAKAKRQFVNEWAAEIPGGPEAASA----------------- 48

  Fly    49 RRGVDNSFAHDVADKYGFDNLGPLVGADGHEYHFKHRTLPHARSRRSLTH-TRALKSHPAVHTAV 112
                       :|::.|:|.||.:...:.| |.|||:..|. |||||..| |:.|.....|..|.
Human    49 -----------IAEELGYDLLGQIGSLENH-YLFKHKNHPR-RSRRSAFHITKRLSDDDRVIWAE 100

  Fly   113 QQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPMQWYLKNTGQNGGKVRLDLNV 177
            ||...:|.||.      |:.....:|.           .||.:..||||::|.......:|||:|
Human   101 QQYEKERSKRS------ALRDSALNLF-----------NDPMWNQQWYLQDTRMTAALPKLDLHV 148

  Fly   178 QAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCA 242
            ...|.:|||||.|...::|||:::.|.|:..||:.||||||:.||..|:|||.....|.||||||
Human   149 IPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCA 213

  Fly   243 GEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASWGPTDDGKTV 307
            ||:|...:|..|||||||:||:.|||||| ..:||.|||:|:|..|..:.||||||||.||||||
Human   214 GEIAMQANNHKCGVGVAYNSKVGGIRMLD-GIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTV 277

  Fly   308 DGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGEE-DDCNCDGYAASMWTISINSAINDGQNAH 371
            :||.....:|...||.:||.|.|:|:|||||:||.: |:|:||||..|::||||:||...|.:..
Human   278 EGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPW 342

  Fly   372 YDESCSSTLASTFSNGAKDPNTGVATTDLYGKCTTTHSGTSAAAPEAAGVFALALEANPQLTWRD 436
            |.|.||||||:::|:| ...:..:.:.||:..||.||:||||:||.|||:|||||||||.|||||
Human   343 YAEKCSSTLATSYSSG-DYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRD 406

  Fly   437 IQHLTVLTSKRNSLFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLS--KQWHSVPPRYHCE 499
            :|||.|.||:.:.|   .|...|..||.||..|..||||:|:|.|:|.|:  :.|.|||.:..|.
Human   407 MQHLVVWTSEYDPL---ANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECV 468

  Fly   500 AGELT-QPQAIVMGRSLFWEIKTDACKGTDTEVNYLEHVQAVISANASRRGDLELFLTSPMGTKS 563
            ..:.. :|:|:.....:..||.|.||:|.:..:..|||||...:...||||||.:.|||..||.:
Human   469 VKDNDFEPRALKANGEVIIEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTST 533

  Fly   564 MILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRH-GNLLEWSLVLHGTKEA 627
            ::|:.|..|.. .:||..|.||:.|:|||.|.|||.|.....|.:.:: |.::.|.|:||||...
Human   534 VLLAERERDTS-PNGFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIVNWKLILHGTSSQ 597

  Fly   628 PYRTLHP 634
            |.....|
Human   598 PEHMKQP 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	24/79 (30%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	160/296 (54%)
		Peptidase_S8	187..459	CDD:278510	148/272 (54%)
		Peptidases_S8_S53	<409..485	CDD:299169	45/75 (60%)
		P_proprotein	534..621	CDD:279782	37/87 (43%)
PCSK1	NP_000430.3	S8_pro-domain	34..110	CDD:293079	29/105 (28%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	121..415	CDD:173789	159/306 (52%)
		Peptidase_S8	158..432	CDD:278510	151/278 (54%)
		P_proprotein	504..591	CDD:279782	37/87 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..662		2/9 (22%)
		Proho_convert	715..751	CDD:288988
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R643
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850