DRSC/TRiP Functional Genomics Resources

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Protein Alignment amon and FURIN

DIOPT Version :10

Sequence 1:NP_477318.1 Gene:amon / 43215 FlyBaseID:FBgn0023179 Length:654 Species:Drosophila melanogaster
Sequence 2:NP_002560.1 Gene:FURIN / 5045 HGNCID:8568 Length:794 Species:Homo sapiens


Alignment Length:625 Identity:296/625 - (47%)
Similarity:382/625 - (61%) Gaps:58/625 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 LAPFLLLHWASAGAGGGAGGSGAGLSGPAVFTSSFLVRFRRGVDNSFAHDVADKYGFDNLGPLVG 74
            |.|:||  |..| |.|......|...|..|||:::.||...|  .:.|:.||.|:||.|||.:. 
Human     3 LRPWLL--WVVA-ATGTLVLLAADAQGQKVFTNTWAVRIPGG--PAVANSVARKHGFLNLGQIF- 61

  Fly    75 ADGHEYHFKHRTLPHARSRRSLT-----HTRALKSHPAVHTAVQQPGFKRVKRGLRPAVPAIHGM 134
              |..|||.||.:    ::|||:     |:| |:..|.|....||...:|.||.           
Human    62 --GDYYHFWHRGV----TKRSLSPHRPRHSR-LQREPQVQWLEQQVAKRRTKRD----------- 108

  Fly   135 KFDLKVGEGNRIDEEPTDPYFPMQWYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTAIMDDGV 199
                       :.:|||||.||.||||      .|..:.||||:||||||.||..:..:|:|||:
Human   109 -----------VYQEPTDPKFPQQWYL------SGVTQRDLNVKAAWAQGYTGHGIVVSILDDGI 156

  Fly   200 DYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKI 264
            :..||||..||:..||:|.:..||.|.||||....|.|||||||||||..:||:|||||||:::|
Human   157 EKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARI 221

  Fly   265 AGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNGL 329
            .|:||||.. :||.:||.|:|..|:.||||||||||.|||||||||......|..:||::||.||
Human   222 GGVRMLDGE-VTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGL 285

  Fly   330 GNIYVWASGDGG-EEDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAKDPNT 393
            |:|:|||||:|| |.|.||||||..|::|:||:||...|....|.|:||||||:|:|:|.::...
Human   286 GSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQ 350

  Fly   394 GVATTDLYGKCTTTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRNSLFDAKNRFH 458
             :.||||..|||.:|:||||:||.|||:.||.||||..|||||:|||.|.|||...|    |...
Human   351 -IVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHL----NAND 410

  Fly   459 WTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSVPPRYHCEAGELTQPQAIVMGRSLFWEIKTDA 523
            |..||||.:.:|.:|:|:|||||||.|::.|.:|.|:..|....||:|:.|  |:.|.......|
Human   411 WATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDI--GKRLEVRKTVTA 473

  Fly   524 CKGTDTEVNYLEHVQAVISANASRRGDLELFLTSPMGTKSMILSRRANDDDHRDGFTKWPFMTTH 588
            |.|....:..|||.||.::.:.:|||||.:.|.|||||:|.:|:.|.:|.. .|||..|.|||||
Human   474 CLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYS-ADGFNDWAFMTTH 537

  Fly   589 SWGEYPQGTWKLEARFNSPQTRHGNLLEWSLVLHGTKEAP 628
            ||.|.|.|.|.||....|....:|.|.:::|||:||  ||
Human   538 SWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGT--AP 575

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
amonNP_477318.1 S8_pro-domain 43..122 CDD:465126 29/83 (35%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 150..446 CDD:173789 171/296 (58%)
Peptidases_S8_S53 <409..485 CDD:415849 44/75 (59%)
P_proprotein 534..621 CDD:460225 41/86 (48%)
FURINNP_002560.1 S8_pro-domain 33..107 CDD:465126 29/83 (35%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 113..402 CDD:173789 171/296 (58%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 162..183 9/20 (45%)
P_proprotein 484..570 CDD:460225 41/86 (48%)
Cell attachment site. /evidence=ECO:0000255 498..500 1/1 (100%)
FU 1. /evidence=ECO:0000255 577..620
FU 581..618 CDD:214589
FU 2. /evidence=ECO:0000255 638..681
FU 638..>675 CDD:214589
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..696
Cell surface signal. /evidence=ECO:0000303|PubMed:9412467 759..762
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 767..794
Trans Golgi network signal. /evidence=ECO:0000269|PubMed:8846780 773..779
Blue background indicates that the domain is not in the aligned region.

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