DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amon and mbtps1

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_954683.2	Gene:	mbtps1 / 326710	ZFINID:	ZDB-GENE-030131-4909	Length:	1074	Species:	Danio rerio

Alignment Length:	506	Identity:	115/506 - (22%)
Similarity:	172/506 - (33%)	Gaps:	121/506 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 FTSSFLVRFRRGVDNSFAHDV-ADKYGF---DNLGPLVGADGHEYHFKHRTLPHARSRRSLTHTR 100
            |...|..:.|....:|...|| |.|:..   ||......:|......|..|      |.||.
Zfish    70 FNGYFTAKARSDFISSALRDVDAVKWRIVRRDNPASDYPSDFEVVEIKQDT------RNSLL--- 125

  Fly   101 ALKSHPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPMQWYLK--- 162
            .|:.||.:         |||    .|....:..:||.....:|       ..|....:|..|
Zfish   126 TLQDHPYI---------KRV----TPQRMVLRSLKFTDSGTDG-------ASPCNDTRWVQKWQS 170

  Fly   163 --------------------NTGQNGGK---------VRLDLNVQAAWAQGITGKNVTTAIMDDG 198
                                .||::..:         |...|.....|..|.||..|..|:.|.|
Zfish   171 WQSSRPLRRTSLSLSSGFWHATGRHSSRRLLRAIPRHVAQILQADVLWQMGHTGSGVKVAVFDTG 235

  Fly   199 VDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSK 263
            :...||..|   |.:...::::.      :..||.. .|||..||.:|:.|:   | .|.|.||:
Zfish   236 LSEKHPHFK---NVKERTNWTNE------KTLDDGL-GHGTFVAGVIASMRE---C-QGFAPDSE 286

  Fly   264 IAGIRMLDQ---PYMTDLIEANSMGHEPHKIHIYSASWGPTD--DGKTVDGPRNATMRAIVQGVN 323
            :...|:...   .|.:..::|.:.. ...||.:.:.|.|..|  |...||.....|...::.
Zfish   287 LHIFRVFTNNQVSYTSWFLDAFNYA-ILKKIDVLNLSIGGPDFMDHPFVDKVWELTANKVIM--- 347

  Fly   324 EGRNGLGNIYVWASGDGGEEDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGA 388
              .:.:||       ||......|  ..|..|..|.:.....:...|.:.....:|.......|.
Zfish   348 --VSAIGN-------DGPLYGTLN--NPADQMDVIGVGGIDFEDNIARFSSRGMTTWELPGGYGR 401

  Fly   389 KDPN-----TGVATTDLYGKCTTTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRN 448
            ..|:     :||..:.|...|.:. ||||.|:|..||  |:.|.|:..|.    :.|....|.:.
Zfish   402 VKPDIVTYGSGVRGSGLKEGCRSL-SGTSVASPVVAG--AVTLLASTVLN----RELVNPASMKQ 459

  Fly   449 SLFDAKNRFHWTMNGVGLEFNHLFGFGVLD---AGAMVTLSKQWHSVPPRY 496
            :|..:..|    :.||.: |..  |.|.||   |..::...|...|:.|.|
Zfish   460 ALIASARR----LPGVNM-FEQ--GHGKLDLLRAYQILNSYKPQASLSPSY 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	21/82 (26%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	74/337 (22%)
		Peptidase_S8	187..459	CDD:278510	67/281 (24%)
		Peptidases_S8_S53	<409..485	CDD:299169	24/78 (31%)
		P_proprotein	534..621	CDD:279782
mbtps1	NP_954683.2	Peptidases_S8_SKI-1_like	218..470	CDD:173805	70/291 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900