DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amon and Fur2

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster

Alignment Length:	657	Identity:	281/657 - (42%)
Similarity:	364/657 - (55%)	Gaps:	82/657 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 AVFTSSFLVRFRRGVDNSFAHDVADKYGFDNLGPLVGADGHEYHFKHRTLPHARSRRSLTHTRAL 102
            |::|:.|.|....|  ...|..:|.|:||.|.|.:...|.: |.|:|..:.....|.|..|..||
  Fly   237 AIYTNEFAVNIPAG--KQMADVIATKHGFINRGQIGSLDNY-YLFQHHHVSKRSLRSSRKHQGAL 298

  Fly   103 KSHPAVHTAVQQPGFKRVKR-GLRPAVPAI--------HGMKFDLKVGEGNRIDEEP-------- 150
            ||...|....||....|.|| |....:|..        ||         |..:|..|
  Fly   299 KSENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHG---------GYVVDPNPHLSFSPES 354

  Fly   151 ---------------------TDPYFPMQWYLKNTGQNGG-KVRLDLNVQAAWAQGITGKNVTTA 193
                                 .||.|..||||  ..:||| |..||:||..||.:|.|||.|..:
  Fly   355 ISLASHSQRMEYRDVSSHFIFPDPLFKEQWYL--VSKNGGAKDGLDMNVGPAWQKGYTGKGVVVS 417

  Fly   194 IMDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGV 258
            |:|||:...||||..||:.|||:|.:.||..|.|:  |:..|.|||||||||||...|..|||||
  Fly   418 ILDDGIQTNHPDLAQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGV 480

  Fly   259 AYDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVN 323
            ||::.|.|:||||.. :.|::||.::...|..|.||||||||.|||.|||||.....||.:.||.
  Fly   481 AYNASIGGVRMLDGK-VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVT 544

  Fly   324 EGRNGLGNIYVWASGDGGE-EDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNG 387
            .||.|.|:|:|||||:||. .|.||||||..|::|:||:||...|....|.|.||||||:|:|:|
  Fly   545 SGRQGKGSIFVWASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSG 609

  Fly   388 AKDPNTGVATTDLYGK------CTTTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSK 446
            ....:..|||.|:.|.      ||..|:||||:||.|||:.||||||||:|||||:|:|.|.||
  Fly   610 TPGHDKSVATVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTS- 673

  Fly   447 RNSLFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSVPPRYHCEAGELTQPQAI-- 509
            |.:..:.:|  .||:|||..:::|.||:|::||||||:|::||.||||::.|::.|..:.:.|
  Fly   674 RPAPLEKEN--GWTLNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDG 736

  Fly   510 VMGRSLFWEIKTDACKGTDTEVNYLEHVQAVISANASRRGDLELFLTSPMGTKSMILSRRANDDD 574
            ..|.:|...:..:.|.||..||.||||||..|:.....||:|.:.|||||||.|.:|..|.. |.
  Fly   737 AYGSTLSTHMDVNGCAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPR-DI 800

  Fly   575 HRDGFTKWPFMTTHSWGEYPQGTWKLEA------RFNSPQTRHGNLLEWSLVLHGTKEAPYR--- 630
            .:..|..|||::.|.|||..:|.|.|:.      |.|.|    |.|.:|.|:.:||...|.|
  Fly   801 VKSNFDDWPFLSVHFWGEKAEGRWTLQVINGGRRRVNQP----GILSKWQLIFYGTSTQPMRLKS 861

  Fly   631 TLHPSSP 637
            .|..|||
  Fly   862 ELLNSSP 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	25/78 (32%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	164/332 (49%)
		Peptidase_S8	187..459	CDD:278510	147/278 (53%)
		Peptidases_S8_S53	<409..485	CDD:299169	44/75 (59%)
		P_proprotein	534..621	CDD:279782	38/92 (41%)
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	25/78 (32%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	164/304 (54%)
		Peptidase_S8	411..700	CDD:278510	155/294 (53%)
		P_proprotein	761..849	CDD:279782	38/92 (41%)
		Furin-like	966..1126	CDD:279142
		FU	970..1013	CDD:238021
		FU	1017..1067	CDD:238021
		FU	1063..1106	CDD:214589
		GF_recep_IV	1068..1232	CDD:291509
		FU	1116..1163	CDD:238021
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442798
Domainoid	1	1.000	250	1.000	Domainoid score	I407
eggNOG	1	0.900	-	-		E1_COG1404
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12785at7147
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	1	1.000	-	-		otm46475
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42884
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.850