DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amon and Pcsk7

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_062119.1	Gene:	Pcsk7 / 29606	RGDID:	3275	Length:	783	Species:	Rattus norvegicus

Alignment Length:	622	Identity:	239/622 - (38%)
Similarity:	319/622 - (51%)	Gaps:	62/622 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 GGAGGSGAGLSGPAVFTSSFLVRFRRGVDNSFAHDVADKYGFDNLGPLVGADGHEYHF----KHR 85
            ||....|||....||...|.....:.......|:.||...|..|.|.:....|| |.|    .|.
  Rat    41 GGLDTLGAGGLSWAVHLDSLEGERKEESLIQQANAVAQAAGLVNAGRIGELQGH-YLFVQPAGHG 104

  Fly    86 TLPHARSRRSLTHTRALKSHPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEP 150
            ....|.:.|..... .|..|.||....:|...||.||       :||   |:
  Rat   105 QAMEAEAMRQQAEA-VLAKHEAVRWHSEQRLLKRAKR-------SIH---FN------------- 145

  Fly   151 TDPYFPMQWYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEAS 215
             ||.:|.||:|.|....|    .|:||...|.:.:||:.||..::||||::...|:..||:.|.|
  Rat   146 -DPKYPQQWHLNNRRSPG----RDINVTGVWERNVTGRGVTVVVVDDGVEHTVQDIAPNYSPEGS 205

  Fly   216 YDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIE 280
            ||.:||||.|.|...::..|.||||||||:||..:|..|.|||||.|:|||||:||.| :||.:|
  Rat   206 YDLNSNDPDPMPHPDEENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGP-LTDSME 269

  Fly   281 ANSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGE-ED 344
            |.:.........|||.||||.|||||||||......|:..||..||.|.|:|:|.|||:||: .|
  Rat   270 AVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVMAGRQGFGSIFVVASGNGGQHND 334

  Fly   345 DCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAKDPNTGVATTDLYGK----CT 405
            :||.||||.|::|::|.:...:|:...|.|.|:|.||.|||.|.|...: :.|||...:    ||
  Rat   335 NCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRS-IVTTDWDLQKGTGCT 398

  Fly   406 TTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRNSLFDAKNRFHWTMNGVGLEFNH 470
            ..|:|||||||.|||:.||.|:..|.|||||:||:.|.|:.:..    .:|..|..|..|...:|
  Rat   399 EGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATQYE----DHRADWLTNEAGFSHSH 459

  Fly   471 LFGFGVLDAGAMVTLSKQWHSVPPRYHCEAGELTQPQAIVMGRS-----LFWEIKTDACKGTDTE 530
            ..|||:|:|..:|..:|.|.|||......:..|.:.:|:  .||     :.|.:..     ||.|
  Rat   460 QHGFGLLNAWRLVNAAKIWTSVPYLASYVSPMLKENKAV--PRSPHSLEVLWNVSR-----TDLE 517

  Fly   531 VN---YLEHVQAVISANASRRGDLELFLTSPMGTKSMILSRRANDDDHRDGFTKWPFMTTHSWGE 592
            ::   .||||...:|....|||.|||.|..|.|..|:|.:.|:.|.| .:||..|.|.|...|||
  Rat   518 MSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSD-PNGFNDWTFSTVRCWGE 581

  Fly   593 YPQGTWKLEAR-FNSPQTRHGNLLEWSLVLHGTKEAP 628
            ..:|.::|..| ......:.|.|.:|.|.|:|:..:|
  Rat   582 RARGVYRLVIRDVGDEPLQVGILQQWQLTLYGSTWSP 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	21/82 (26%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	145/300 (48%)
		Peptidase_S8	187..459	CDD:278510	133/276 (48%)
		Peptidases_S8_S53	<409..485	CDD:299169	34/75 (45%)
		P_proprotein	534..621	CDD:279782	34/87 (39%)
Pcsk7	NP_062119.1	S8_pro-domain	52..140	CDD:293079	23/89 (26%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	144..439	CDD:173789	146/314 (46%)
		Peptidase_S8	195..439	CDD:278510	125/245 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..228		14/32 (44%)
		P_proprotein	524..611	CDD:279782	34/87 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	761..783
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820