DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amon and PCSK9

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_777596.2	Gene:	PCSK9 / 255738	HGNCID:	20001	Length:	692	Species:	Homo sapiens

Alignment Length:	319	Identity:	73/319 - (22%)
Similarity:	123/319 - (38%)	Gaps:	68/319 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 RIDE-EPTDPYFPMQWYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTAI----MDDGVDYMHP 204
            |.|| :|.|....::.||           ||.::|:...: |.|:.:.|..    .:||.
Human   167 RADEYQPPDGGSLVEVYL-----------LDTSIQSDHRE-IEGRVMVTDFENVPEEDGT----- 214

  Fly   205 DLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRM 269
                .::.:||.                 .:||||..|| |.:.||     .|||..:.:..:|:
Human   215 ----RFHRQASK-----------------CDSHGTHLAG-VVSGRD-----AGVAKGASMRSLRV 252

  Fly   270 LD-QPYMTDLIEANSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIY 333
            |: |...|  :....:|.|..:........||......:.|..:..:.|..|.:  .|.|:
Human   253 LNCQGKGT--VSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRL--ARAGV---- 309

  Fly   334 VWASGDGGEEDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAK--DPNTGV- 395
            |..:..|...||......|::...|::.:.     ||........||.:.|.....  .|...:
Human   310 VLVTAAGNFRDDACLYSPASAPEVITVGAT-----NAQDQPVTLGTLGTNFGRCVDLFAPGEDII 369

  Fly   396 -ATTDLYGKCTTTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRNSLFDA 453
             |::|. ..|..:.||||.||...||:.|:.|.|.|:||..:::...:..|.::.:.:|
Human   370 GASSDC-STCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEA 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	68/304 (22%)
		Peptidase_S8	187..459	CDD:278510	62/276 (22%)
		Peptidases_S8_S53	<409..485	CDD:299169	16/45 (36%)
		P_proprotein	534..621	CDD:279782
PCSK9	NP_777596.2	Inhibitor_I9	77..149	CDD:283552
		Peptidases_S8_PCSK9_ProteinaseK_like	156..421	CDD:173790	72/311 (23%)
		Peptidase_S8	180..422	CDD:278510	67/299 (22%)
		C-terminal domain	450..692
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900