DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amon and tpp2

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_594951.1	Gene:	tpp2 / 2543179	PomBaseID:	SPAP8A3.12c	Length:	1274	Species:	Schizosaccharomyces pombe

Alignment Length:	740	Identity:	161/740 - (21%)
Similarity:	258/740 - (34%)	Gaps:	191/740 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GAGGGAG----GSGAGLSGPAVFTSSFLVRFRRGVDNSFAHDVADKYGFDNLGPLVGADGHEYHF 82
            |.|...|    |...|..|.:| |::.|.:|:..||.:.|.||      |....:..||.::|
pombe    92 GRGVTVGILDTGVDPGAPGLSV-TTTGLPKFKNIVDCTGAGDV------DTSVEVAAADSNDY-- 147

  Fly    83 KHRTLPHARSRRSLTHTRALKSHPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKF---DLK----- 139
              .|:. .||.|:|..::..| :|:          |:.|.|.:.|      .:|   ||:
pombe   148 --LTIT-GRSGRTLKLSKEWK-NPS----------KKWKVGCKLA------YEFFPKDLRKRLQK 192

  Fly   140 -----VGEGNR-IDEEPTDPY------FPMQWYLKNTGQNGGKV--RLDLNVQAAWAQGITGKNV 190
                 :.:.|| :.::.||.|      ||.....|:..|...::  |::...|.|......|...
pombe   193 LETEDMNKSNRKLLQDATDEYAKFKDKFPEAPLDKDNLQTQKELEARIECLKQLAEKFDNPGPLY 257

  Fly   191 TTAIMDDG------VD-------YMH-PDLKFNYNAEASYDFSSNDPFPYPRYTDDWFN------ 235
            ...:..||      :|       |:| |...||...|.| .|.|.|...|..:..|..|
pombe   258 DVVVFHDGEHWRVVIDSDQTGDIYLHKPLADFNVAQEWS-TFGSLDLLSYGVHVYDNGNITSIVA 321

  Fly   236 ---SHGTRCAGEVAAARD-----NGICGVGVAYDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIH 292
               :|||..||.:.|...     || ...|....|.:.|...||....:............:::.
pombe   322 VSGTHGTHVAGIIGANHPETPELNG-AAPGCQLVSLMIGDGRLDSLETSHAFSRACSEIIKNEVD 385

  Fly   293 IYSASWGP----TDDGKTVDGPRN--ATMRAIVQGVNEGRNGLGNIYVWASGDGGEEDDCNCDGY 351
            |.:.|:|.    .:.|:.::..|:  |..|.:|...:.|.|  |..|......||...|
pombe   386 IINISFGEDAGIPNKGRVIELLRDELAGKRNVVIVSSAGNN--GPAYTTVGAPGGTTFD------ 442

  Fly   352 AASMWTISINSAINDG-QNAHYDESCSSTLAST----FSNG-AKDPNTGVATTDLYGKCTTT--- 407
                 .||:.:.:..| ..|.|  :..||:..|    .|.| ..|.:|||:.....|..|:.
pombe   443 -----VISVGAYVTSGMMQAQY--NLLSTVHDTPYTWCSRGPTLDGDTGVSIYAPGGAITSVPPY 500

  Fly   408 -------HSGTSAAAPEAAGVFALALEA----NPQLTWRDIQHLTVLTSK------RNSLFDAKN 455
                   .:|||.::|.|.|..:|.|.|    ....|...|:...:.|||      ...:....|
pombe   501 SLQNSQLMNGTSMSSPSACGGISLILSALKAQKKPYTAAAIKKAVMYTSKDLRDDFNTGMLQVDN 565

  Fly   456 RFHW--------------TMNG-VGLEFNHLFGFGVLDAGAMVTLSKQWHSVPPRYHCEAGE--- 502
            .:.:              |:|| :|   |...|..:.:...:.:.|:...:|.|::  |.||
pombe   566 AYEYLAQSDFQYTGARSFTINGNIG---NSKRGVYLRNPTEVCSPSRHMFNVAPKF--EDGEEYE 625

  Fly   503 ----------------LTQPQAIVM---GRSLFWEIKTDACKGTDTEVNYLEHVQAVISANASRR 548
                            :..|:.::|   ||.:...:...|.    ...::...|.|..::|.|||
pombe   626 KSHFEVQLSLATTQPWIQAPEYVMMAGTGRGIPVRVDPTAL----APGHHFGKVLAYDASNESRR 686

  Fly   549 GDLELFLT--SPMGTKSMILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRH 611
            ...|:.:|  .|....:...|.|  |........|..|:..      |:|...:|.|..:.....
pombe   687 CVFEIPVTVMKPSSISNTCFSLR--DVSFEPTLIKRHFLVP------PKGATYVEIRVKATSELE 743

  Fly   612 GNLLEWSLVLHGTKEAPYRTLHPSS 636
            ...:.|..|   .:..|...|:.:|
pombe   744 STNMLWISV---NQTIPQTKLNEAS 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	19/78 (24%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	83/357 (23%)
		Peptidase_S8	187..459	CDD:278510	76/331 (23%)
		Peptidases_S8_S53	<409..485	CDD:299169	21/100 (21%)
		P_proprotein	534..621	CDD:279782	19/88 (22%)
tpp2	NP_594951.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	71..552	CDD:173796	120/505 (24%)
		Peptidase_S8	271..552	CDD:278510	72/297 (24%)
		TPPII	837..1008	CDD:289357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42884
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000