DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amon and Pcsk1

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_058787.1	Gene:	Pcsk1 / 25204	RGDID:	3272	Length:	752	Species:	Rattus norvegicus

Alignment Length:	605	Identity:	266/605 - (43%)
Similarity:	362/605 - (59%)	Gaps:	41/605 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VRFRRGVDNSFAHD----------VADKYGFDNLGPLVGADGHEYHFKHRTLPHARSRRSLTH-T 99
            |:.:|...|.:|.:          :|::.|:|.||.:...:.| |.|||:..|. |||||..| |
  Rat    25 VKAKRQFVNEWAAEIHGGPEAASAIAEELGYDLLGQIGSLENH-YLFKHKNHPR-RSRRSALHIT 87

  Fly   100 RALKSHPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPMQWYLKNT 164
            :.|.....|..|.||...:|.||    :||....:...             .||.:..||||::|
  Rat    88 KRLSDDDRVIWAEQQYEKERRKR----SVPRDSALNLF-------------NDPMWNQQWYLQDT 135

  Fly   165 GQNGGKVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRY 229
            .......:|||:|...|.:|||||.|...::|||:::.|.|:..||:.||||||:.||..|:|||
  Rat   136 RMTASLPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRY 200

  Fly   230 TDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIY 294
            .....|.||||||||:|...:|..|||||||:||:.|||||| ..:||.|||:|:|..|..:.||
  Rat   201 DPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLD-GIVTDAIEASSIGFNPGHVDIY 264

  Fly   295 SASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGEE-DDCNCDGYAASMWTI 358
            ||||||.||||||:||.....:|...||.:||.|.|:|:|||||:||.: |:|:||||..|::||
  Rat   265 SASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTI 329

  Fly   359 SINSAINDGQNAHYDESCSSTLASTFSNGAKDPNTGVATTDLYGKCTTTHSGTSAAAPEAAGVFA 423
            ||:||...|.:..|.|.||||||:::|:| ...:..:.:.||:..||.||:||||:||.|||:||
  Rat   330 SISSASQQGLSPWYAEKCSSTLATSYSSG-DYTDQRITSADLHNDCTETHTGTSASAPLAAGIFA 393

  Fly   424 LALEANPQLTWRDIQHLTVLTSKRNSLFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLS-- 486
            |||||||.|||||:|||.|.||:.:.|   .|...|..||.||..|..||||:|:|.|:|.|:
  Rat   394 LALEANPNLTWRDMQHLVVWTSEYDPL---ANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADP 455

  Fly   487 KQWHSVPPRYHCEAGELT-QPQAIVMGRSLFWEIKTDACKGTDTEVNYLEHVQAVISANASRRGD 550
            :.|.:||.:..|...:.. :|:|:.....:..||.|.||:|.:..:|.|||||...:...|||||
  Rat   456 RTWRNVPEKKECIIKDNNFEPRALKANGEVIVEIPTRACEGQENAINSLEHVQFEATIEYSRRGD 520

  Fly   551 LELFLTSPMGTKSMILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRH-GNL 614
            |.:.|||..||.:::|:.|..|.. .:||..|.||:.|:|||.|.|||.|:....|.:.:: |.:
  Rat   521 LHVTLTSAAGTSTVLLAERERDTS-PNGFKNWDFMSVHTWGENPVGTWTLKVTDMSGRMQNEGRI 584

  Fly   615 LEWSLVLHGTKEAPYRTLHP 634
            :.|.|:||||...|.....|
  Rat   585 VNWKLILHGTSSQPEHMKQP 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	28/86 (33%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	160/296 (54%)
		Peptidase_S8	187..459	CDD:278510	148/272 (54%)
		Peptidases_S8_S53	<409..485	CDD:299169	45/75 (60%)
		P_proprotein	534..621	CDD:279782	37/87 (43%)
Pcsk1	NP_058787.1	S8_pro-domain	34..110	CDD:406785	25/77 (32%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	121..415	CDD:173789	159/308 (52%)
		P_proprotein	504..591	CDD:396185	37/87 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..662
		Proho_convert	712..750	CDD:403415
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820