DRSC/TRiP Functional Genomics Resources

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Protein Alignment amon and Pcsk1

DIOPT Version :10

Sequence 1:NP_477318.1 Gene:amon / 43215 FlyBaseID:FBgn0023179 Length:654 Species:Drosophila melanogaster
Sequence 2:NP_058787.1 Gene:Pcsk1 / 25204 RGDID:3272 Length:752 Species:Rattus norvegicus


Alignment Length:605 Identity:266/605 - (43%)
Similarity:362/605 - (59%) Gaps:41/605 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 VRFRRGVDNSFAHD----------VADKYGFDNLGPLVGADGHEYHFKHRTLPHARSRRSLTH-T 99
            |:.:|...|.:|.:          :|::.|:|.||.:...:.| |.|||:..|. |||||..| |
  Rat    25 VKAKRQFVNEWAAEIHGGPEAASAIAEELGYDLLGQIGSLENH-YLFKHKNHPR-RSRRSALHIT 87

  Fly   100 RALKSHPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPMQWYLKNT 164
            :.|.....|..|.||...:|.||    :||....:...             .||.:..||||::|
  Rat    88 KRLSDDDRVIWAEQQYEKERRKR----SVPRDSALNLF-------------NDPMWNQQWYLQDT 135

  Fly   165 GQNGGKVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRY 229
            .......:|||:|...|.:|||||.|...::|||:::.|.|:..||:.||||||:.||..|:|||
  Rat   136 RMTASLPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRY 200

  Fly   230 TDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIY 294
            .....|.||||||||:|...:|..|||||||:||:.|||||| ..:||.|||:|:|..|..:.||
  Rat   201 DPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLD-GIVTDAIEASSIGFNPGHVDIY 264

  Fly   295 SASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGEE-DDCNCDGYAASMWTI 358
            ||||||.||||||:||.....:|...||.:||.|.|:|:|||||:||.: |:|:||||..|::||
  Rat   265 SASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTI 329

  Fly   359 SINSAINDGQNAHYDESCSSTLASTFSNGAKDPNTGVATTDLYGKCTTTHSGTSAAAPEAAGVFA 423
            ||:||...|.:..|.|.||||||:::|:| ...:..:.:.||:..||.||:||||:||.|||:||
  Rat   330 SISSASQQGLSPWYAEKCSSTLATSYSSG-DYTDQRITSADLHNDCTETHTGTSASAPLAAGIFA 393

  Fly   424 LALEANPQLTWRDIQHLTVLTSKRNSLFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLS-- 486
            |||||||.|||||:|||.|.||:.:.|   .|...|..||.||..|..||||:|:|.|:|.|:  
  Rat   394 LALEANPNLTWRDMQHLVVWTSEYDPL---ANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADP 455

  Fly   487 KQWHSVPPRYHCEAGELT-QPQAIVMGRSLFWEIKTDACKGTDTEVNYLEHVQAVISANASRRGD 550
            :.|.:||.:..|...:.. :|:|:.....:..||.|.||:|.:..:|.|||||...:...|||||
  Rat   456 RTWRNVPEKKECIIKDNNFEPRALKANGEVIVEIPTRACEGQENAINSLEHVQFEATIEYSRRGD 520

  Fly   551 LELFLTSPMGTKSMILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRH-GNL 614
            |.:.|||..||.:::|:.|..|.. .:||..|.||:.|:|||.|.|||.|:....|.:.:: |.:
  Rat   521 LHVTLTSAAGTSTVLLAERERDTS-PNGFKNWDFMSVHTWGENPVGTWTLKVTDMSGRMQNEGRI 584

  Fly   615 LEWSLVLHGTKEAPYRTLHP 634
            :.|.|:||||...|.....|
  Rat   585 VNWKLILHGTSSQPEHMKQP 604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
amonNP_477318.1 S8_pro-domain 43..122 CDD:465126 28/86 (33%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 150..446 CDD:173789 160/296 (54%)
Peptidases_S8_S53 <409..485 CDD:415849 45/75 (60%)
P_proprotein 534..621 CDD:460225 37/87 (43%)
Pcsk1NP_058787.1 S8_pro-domain 34..110 CDD:465126 25/77 (32%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 121..415 CDD:173789 159/308 (52%)
P_proprotein 504..591 CDD:460225 37/87 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..662
Proho_convert 712..750 CDD:463483
Blue background indicates that the domain is not in the aligned region.

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