Protein Alignment amon and Pcsk2

DIOPT Version :10

• Sequence 1: NP_477318.1
• Gene: amon / 43215
• FlyBaseID: FBgn0023179
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_036878.1
• Gene: Pcsk2 / 25121
• RGDID: 3273
• Length: 637
• Species: Rattus norvegicus
• Alignment Length: 641
• Identity: 386/641 - (60%)
• Similarity: 454/641 - (70%)
• Gaps: 33/641 - (5%)

  Fly    25 GGAGG--SGAGL---------SGPAVFTSSFLVRFRRGVDNSFAHDVADKYGFDNLGPLVGADGH 78
            ||.|.  ..|||         :...|||:.|||...:..:.. |..||.::|| .:..|..|:|
  Rat     3 GGCGSQWKAAGLLFCVMVFASAERPVFTNHFLVELHKDGEEE-ARQVAAEHGF-GVRKLPFAEG- 64

  Fly    79 EYHFKHRTLPHARSRRSLTHTRALKSHPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEG 143
            .|||.|..|..|:.||||.|.|.|:..|.:..|:||.||.|.|||.|           |:
  Rat    65 LYHFYHNGLAKAKRRRSLHHKRQLERDPRIKMALQQEGFDRKKRGYR-----------DI----- 113

  Fly   144 NRIDEEPTDPYFPMQWYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKF 208
            |.||....||.|..||||.||||..|...|||||..||..|.|||.||..|||||:||:||||.:
  Rat   114 NEIDINMNDPLFTKQWYLFNTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLAY 178

  Fly   209 NYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQP 273
            |||::||||||||||:|||||||||||||||||||||:||..|.||||||||:||:|||||||||
  Rat   179 NYNSDASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAASNNICGVGVAYNSKVAGIRMLDQP 243

  Fly   274 YMTDLIEANSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASG 338
            :|||:|||:|:.|.|..|.||||||||||:||||||||..|::|:..|||:||.|.|:|||||||
  Rat   244 FMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASG 308

  Fly   339 DGGEEDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAK-DPNTGVATTDLYG 402
            |||..|||||||||:||||||||||||||:.|.||||||||||||||||.| :|..|||||||||
  Rat   309 DGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYG 373

  Fly   403 KCTTTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRNSLFDAKNRFHWTMNGVGLE 467
            .||..||||||||||||||||||||||..|||||:|||||||||||.|.|..::  |..||||||
  Rat   374 NCTLRHSGTSAAAPEAAGVFALALEANVDLTWRDMQHLTVLTSKRNQLHDEVHQ--WRRNGVGLE 436

  Fly   468 FNHLFGFGVLDAGAMVTLSKQWHSVPPRYHCEAGELTQPQAIVMGRSLFWEIKTDACKGTDTEVN 532
            ||||||:|||||||||.::|.|.:||.|:||..|.:..|:.|.....|...::|:||:|.:..|.
  Rat   437 FNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQNPEKIPPTGKLVLTLQTNACEGKENFVR 501

  Fly   533 YLEHVQAVISANASRRGDLELFLTSPMGTKSMILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGT 597
            |||||||||:.||:|||||.:.:||||||||::||||..|||.:.||.||||||||:|||..:||
  Rat   502 YLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGT 566

  Fly   598 WKLEARFNSPQTRHGNLLEWSLVLHGTKEAPYRTLHPSSPHSKLAIVKKAHEDKKM 653
            |.||..|.....:.|.|.||:|:||||:.|||.........||||:.||...::::
  Rat   567 WTLELGFVGSAPQKGLLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKQELEEEL 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:465126	31/78 (40%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	150..446	CDD:173789	226/296 (76%)
		Peptidases_S8_S53	<409..485	CDD:415849	61/75 (81%)
		P_proprotein	534..621	CDD:460225	54/86 (63%)
Pcsk2	NP_036878.1	S8_pro-domain	32..108	CDD:465126	31/78 (40%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	121..417	CDD:173789	226/295 (77%)
		P_proprotein	503..590	CDD:460225	54/86 (63%)