DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amon and Pcsk7

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001268863.1	Gene:	Pcsk7 / 18554	MGIID:	107421	Length:	770	Species:	Mus musculus

Alignment Length:	641	Identity:	241/641 - (37%)
Similarity:	321/641 - (50%)	Gaps:	62/641 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 WSWLLAPFLLLHWASAGAGGGAGGSGAGLSGPAVFTSSFLVRFRRGVDNSFAHDVADKYGFDNLG 70
            |..|...||:.........||....|.|....||...|.....:.......|..||...|..|.|
Mouse    22 WLELAIFFLVPQVMGLSEAGGLDILGTGGLSWAVHLDSLEGERKEESLTQQADAVAQAAGLVNAG 86

  Fly    71 PLVGADGHEYHF----KHRTLPHARSRRSLTHTRALKSHPAVHTAVQQPGFKRVKRGLRPAVPAI 131
            .:....|| |.|    .||......:.|..... .|..|.||....:|...||.||       :|
Mouse    87 RIGELQGH-YLFVQPTGHRQAMEVEAMRQQAEA-VLARHEAVRWHSEQTLLKRAKR-------SI 142

  Fly   132 HGMKFDLKVGEGNRIDEEPTDPYFPMQWYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTAIMD 196
            |   |:              ||.:|.||:|.|....|    .|:||...|.:.:||:.||..::|
Mouse   143 H---FN--------------DPKYPQQWHLNNRRSPG----RDINVTGVWERNVTGRGVTVVVVD 186

  Fly   197 DGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYD 261
            |||::...|:..||:.|.|||.:||||.|.|...::..|.||||||||:||..:|..|.|||||.
Mouse   187 DGVEHTVQDIAPNYSPEGSYDLNSNDPDPMPHPDEENGNHHGTRCAGEIAAVPNNSFCAVGVAYG 251

  Fly   262 SKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNEGR 326
            |:|||||:||.| :||.:||.:.........|||.||||.|||||||||......|:..||..||
Mouse   252 SRIAGIRVLDGP-LTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVMAGR 315

  Fly   327 NGLGNIYVWASGDGGE-EDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAKD 390
            .|.|:|:|.|||:||: .|:||.||||.|::|::|.:...:|:...|.|.|:|.||.|||.|.|.
Mouse   316 QGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKM 380

  Fly   391 PNTGVATTDLYGK----CTTTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRNSLF 451
            ..: :.|||...:    ||..|:|||||||.|||:.||.|:..|.|||||:||:.|.|:.:..
Mouse   381 LRS-IVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTAIQYE-- 442

  Fly   452 DAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSVPPRYHCEAGELTQPQAIVMGRS-- 514
              .:...|..|..|...:|..|||:|:|..:|..:|.|.|||......:..|.:.:|:  .||
Mouse   443 --DHHADWLTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPMLKENKAV--PRSPH 503

  Fly   515 ---LFWEIKTDACKGTDTEVN---YLEHVQAVISANASRRGDLELFLTSPMGTKSMILSRRANDD 573
               :.|.:..     ||.|::   .||||...:|....|||.|||.|..|.|..|:|.:.|:.|.
Mouse   504 SLEVLWNVSR-----TDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDS 563

  Fly   574 DHRDGFTKWPFMTTHSWGEYPQGTWKLEAR-FNSPQTRHGNLLEWSLVLHGTKEAP 628
            | .:||..|.|.|...|||..:|.::|..| ......:.|.|.:|.|.|:|:..:|
Mouse   564 D-PNGFNAWTFSTVRCWGERARGVYRLVIRDVGDEPLQMGILQQWQLTLYGSMWSP 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	21/82 (26%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	145/300 (48%)
		Peptidase_S8	187..459	CDD:278510	132/276 (48%)
		Peptidases_S8_S53	<409..485	CDD:299169	33/75 (44%)
		P_proprotein	534..621	CDD:279782	34/87 (39%)
Pcsk7	NP_001268863.1	S8_pro-domain	52..140	CDD:406785	23/89 (26%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	144..438	CDD:173789	145/313 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..228		14/32 (44%)
		P_proprotein	524..611	CDD:396185	34/87 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R643
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850