Protein Alignment amon and Pcsk7

DIOPT Version :10

• Sequence 1: NP_477318.1
• Gene: amon / 43215
• FlyBaseID: FBgn0023179
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_032820.2
• Gene: Pcsk7 / 18554
• MGIID: 107421
• Length: 770
• Species: Mus musculus
• Alignment Length: 641
• Identity: 241/641 - (37%)
• Similarity: 321/641 - (50%)
• Gaps: 62/641 - (9%)

  Fly     6 WSWLLAPFLLLHWASAGAGGGAGGSGAGLSGPAVFTSSFLVRFRRGVDNSFAHDVADKYGFDNLG 70
            |..|...||:.........||....|.|....||...|.....:.......|..||...|..|.|
Mouse    22 WLELAIFFLVPQVMGLSEAGGLDILGTGGLSWAVHLDSLEGERKEESLTQQADAVAQAAGLVNAG 86

  Fly    71 PLVGADGHEYHF----KHRTLPHARSRRSLTHTRALKSHPAVHTAVQQPGFKRVKRGLRPAVPAI 131
            .:....|| |.|    .||......:.|..... .|..|.||....:|...||.||       :|
Mouse    87 RIGELQGH-YLFVQPTGHRQAMEVEAMRQQAEA-VLARHEAVRWHSEQTLLKRAKR-------SI 142

  Fly   132 HGMKFDLKVGEGNRIDEEPTDPYFPMQWYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTAIMD 196
            |   |:              ||.:|.||:|.|....|    .|:||...|.:.:||:.||..::|
Mouse   143 H---FN--------------DPKYPQQWHLNNRRSPG----RDINVTGVWERNVTGRGVTVVVVD 186

  Fly   197 DGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYD 261
            |||::...|:..||:.|.|||.:||||.|.|...::..|.||||||||:||..:|..|.|||||.
Mouse   187 DGVEHTVQDIAPNYSPEGSYDLNSNDPDPMPHPDEENGNHHGTRCAGEIAAVPNNSFCAVGVAYG 251

  Fly   262 SKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNEGR 326
            |:|||||:||.| :||.:||.:.........|||.||||.|||||||||......|:..||..||
Mouse   252 SRIAGIRVLDGP-LTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVMAGR 315

  Fly   327 NGLGNIYVWASGDGGE-EDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAKD 390
            .|.|:|:|.|||:||: .|:||.||||.|::|::|.:...:|:...|.|.|:|.||.|||.|.|.
Mouse   316 QGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKM 380

  Fly   391 PNTGVATTDLYGK----CTTTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRNSLF 451
            ..: :.|||...:    ||..|:|||||||.|||:.||.|:..|.|||||:||:.|.|:.:..
Mouse   381 LRS-IVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTAIQYE-- 442

  Fly   452 DAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSVPPRYHCEAGELTQPQAIVMGRS-- 514
              .:...|..|..|...:|..|||:|:|..:|..:|.|.|||......:..|.:.:|:  .||
Mouse   443 --DHHADWLTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPMLKENKAV--PRSPH 503

  Fly   515 ---LFWEIKTDACKGTDTEVN---YLEHVQAVISANASRRGDLELFLTSPMGTKSMILSRRANDD 573
               :.|.:..     ||.|::   .||||...:|....|||.|||.|..|.|..|:|.:.|:.|.
Mouse   504 SLEVLWNVSR-----TDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDS 563

  Fly   574 DHRDGFTKWPFMTTHSWGEYPQGTWKLEAR-FNSPQTRHGNLLEWSLVLHGTKEAP 628
            | .:||..|.|.|...|||..:|.::|..| ......:.|.|.:|.|.|:|:..:|
Mouse   564 D-PNGFNAWTFSTVRCWGERARGVYRLVIRDVGDEPLQMGILQQWQLTLYGSMWSP 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:465126	21/82 (26%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	150..446	CDD:173789	145/300 (48%)
		Peptidases_S8_S53	<409..485	CDD:415849	33/75 (44%)
		P_proprotein	534..621	CDD:460225	34/87 (39%)
Pcsk7	NP_032820.2	S8_pro-domain	52..140	CDD:465126	23/89 (26%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	144..438	CDD:173789	145/313 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	195..228		14/32 (44%)
		P_proprotein	524..611	CDD:460225	34/87 (39%)