DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amon and Pcsk6

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_035178.1	Gene:	Pcsk6 / 18553	MGIID:	102897	Length:	959	Species:	Mus musculus

Alignment Length:	666	Identity:	283/666 - (42%)
Similarity:	376/666 - (56%)	Gaps:	86/666 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAATWSWLL--------------APFLLLHWASAGAGGGAGGSGAGLSGPAVFTSSFLVRFRRG 51
            :|...|.|||              .|....|||..    ..||.||
Mouse    35 LALRPWRWLLLLALPAACSALPPPRPVYTNHWAVQ----VLGGPGA------------------- 76

  Fly    52 VDNSFAHDVADKYGFDNLGPLVGADGHEYHFKH-RTLPHARSRRSLTHTRA----LKSHPAVHTA 111
                 |..||..:|:.|||.:...|.: |||.| :|.     :||...:|.    |:..|.|...
Mouse    77 -----ADRVAAAHGYLNLGQIGNLDDY-YHFYHSKTF-----KRSTLSSRGPHTFLRMDPQVKWL 130

  Fly   112 VQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPMQWYLKNTGQNGGKVRLDLN 176
            .||...:||||..|.     ..:.|:              ||.:...||:..|.:| .:.|.::|
Mouse   131 QQQEVKRRVKRQARS-----DSLYFN--------------DPIWSNMWYMHCTDKN-SRCRSEMN 175

  Fly   177 VQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRC 241
            |||||.:|.|||||...|:|||::..||||..||::.||||.:.||..|.|||.....|.|||||
Mouse   176 VQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRC 240

  Fly   242 AGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASWGPTDDGKT 306
            ||||||:.:|..|.||:||::||.||||||.. :||::||.|:|..|:.|.||||||||.|||||
Mouse   241 AGEVAASANNSYCIVGIAYNAKIGGIRMLDGD-VTDVVEAKSLGIRPNYIDIYSASWGPDDDGKT 304

  Fly   307 VDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGEE-DDCNCDGYAASMWTISINSAINDGQNA 370
            ||||.....:|...|:.:||.|||:|:|||||:||.| |.|:||||..|::|||::|...:|...
Mouse   305 VDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDHCSCDGYTNSIYTISVSSTTENGHKP 369

  Fly   371 HYDESCSSTLASTFSNGAKDPNTGVATTDLYGKCTTTHSGTSAAAPEAAGVFALALEANPQLTWR 435
            .|.|.|:||||:|:|:||..... :.||||..:||..|:|||.:||..||:.|||||||.|||||
Mouse   370 WYLEECASTLATTYSSGAFYERK-IVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANNQLTWR 433

  Fly   436 DIQHLTVLTSKRNSLFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSVPPRYHCEA 500
            |:|||.|.||:...|    ....|.:||.|.:.:||:|||::||.|:|..:::|.:||.::.|.|
Mouse   434 DVQHLLVKTSRPAHL----KASDWKVNGAGHKVSHLYGFGLVDAEALVLEARKWTAVPSQHVCVA 494

  Fly   501 GELTQPQAIVMGRSLFWEIKTDACKG-TDTEVNYLEHVQAVISANASRRGDLELFLTSPMGTKSM 564
            ....:|::|.:.:.|.....|:||.. :|..|.|||||...||.:..|||||::.|.||.||||.
Mouse   495 TADKRPRSIPIVQVLRTTALTNACADHSDQRVVYLEHVVVRISISHPRRGDLQIHLISPSGTKSQ 559

  Fly   565 ILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRH----GNLLEWSLVLHGTK 625
            :|::|..|..: :|||.|.|||.|.|||..:|.|.||.:....|.|:    |.|.||||:|:||.
Mouse   560 LLAKRLLDFSN-EGFTNWEFMTVHCWGEKAEGEWTLEVQDIPSQVRNPEKQGKLKEWSLILYGTA 623

  Fly   626 EAPYRTLHPSSPHSKL 641
            |.||||.......|::
Mouse   624 EHPYRTFSSHQSRSRM 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	23/83 (28%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	161/296 (54%)
		Peptidase_S8	187..459	CDD:278510	148/272 (54%)
		Peptidases_S8_S53	<409..485	CDD:299169	40/75 (53%)
		P_proprotein	534..621	CDD:279782	44/90 (49%)
Pcsk6	NP_035178.1	S8_pro-domain	65..141	CDD:293079	30/109 (28%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..444	CDD:173789	162/310 (52%)
		Peptidase_S8	186..469	CDD:278510	155/288 (54%)
		P_proprotein	529..619	CDD:279782	44/90 (49%)
		FU	685..737	CDD:238021
		FU	733..779	CDD:214589
		Furin-like_2	741..837	CDD:292535
		FU	787..827	CDD:214589
		FU	834..876	CDD:214589
		PLAC	932..955	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.780