DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amon and Pcsk5

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001177412.1	Gene:	Pcsk5 / 18552	MGIID:	97515	Length:	1877	Species:	Mus musculus

Alignment Length:	683	Identity:	280/683 - (40%)
Similarity:	370/683 - (54%)	Gaps:	111/683 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 WSW-----------------LLAPFLL---------LHWASAGAGGGAGGSGAGLSGPAVFTSSF 44
            |.|                 |||..||         .|||...|||.|.
Mouse     3 WDWGNRCSRPGRRDLLCVLALLAGCLLPVCRTRVYTNHWAVKIAGGFAE---------------- 51

  Fly    45 LVRFRRGVDNSFAHDVADKYGFDNLGPLVGADGHEYHFKH-RTLPHARSRRSLTHTRALKS---- 104
                        |..:|.||||.|:|. :||....|||.| ||:     :||:..:|...|
Mouse    52 ------------ADRIASKYGFINVGQ-IGALKDYYHFYHSRTI-----KRSVLSSRGTHSFISM 98

  Fly   105 HPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPMQWYLKNTGQNGG 169
            .|.|....||...||.||            .:||...:....:    ||.:|..||: :...|..
Mouse    99 EPKVEWIQQQVVKKRTKR------------DYDLSHAQSTYFN----DPKWPSMWYM-HCSDNTH 146

  Fly   170 KVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDWF 234
            ..:.|:|::.||.:|.||||:...|:|||::..||||..||:|.||.|.:.||..|.|||.....
Mouse   147 PCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNE 211

  Fly   235 NSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASWG 299
            |.|||||||||||..:|..|.||:|:::||.|:||||.. :||::||.|:.:.|..:||||||||
Mouse   212 NKHGTRCAGEVAATANNSHCTVGIAFNAKIGGVRMLDGD-VTDMVEAKSVSYNPQHVHIYSASWG 275

  Fly   300 PTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGG-EEDDCNCDGYAASMWTISINSA 363
            |.|||||||||...|.:|...||..||.|||:::|||||:|| .:|.|:||||..|::||||:|.
Mouse   276 PDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISST 340

  Fly   364 INDGQNAHYDESCSSTLASTFSNGAKDPNTGVATTDLYGKCTTTHSGTSAAAPEAAGVFALALEA 428
            ...|:...|.|.||||||:|:|:| :..:..:.||||..:||..|:||||:||.|||:.||||||
Mouse   341 AESGKKPWYLEECSSTLATTYSSG-ESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEA 404

  Fly   429 NPQLTWRDIQHLTVLTSKRNSLFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSVP 493
            ||.|||||:||:.|.||:...|    |...|..|..|.:.:||:|||::||.|||..:::|.:||
Mouse   405 NPFLTWRDVQHVIVRTSRAGHL----NANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVP 465

  Fly   494 PRYHCEAG-----ELTQPQAIVMGRSLFWEIKTDACK-GTDTEVNYLEHVQAVISANASRRGDLE 552
            .::.|...     :..:|.:.|  ||::   |...|. ..:..|||||||...|:....|||||.
Mouse   466 QQHVCVESTDRQIKTIRPNSAV--RSIY---KASGCSDNPNHHVNYLEHVVVRITITHPRRGDLA 525

  Fly   553 LFLTSPMGTKSMILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRH----GN 613
            ::||||.||:|.:|:.|..|.. .:||..|.|||.|.|||...|.|.||......|.|:    |.
Mouse   526 IYLTSPSGTRSQLLANRLFDHS-MEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGK 589

  Fly   614 LLEWSLVLHGTKEAPYRTLHPSSPHSKLAIVKK 646
            |.||||||:||...||      ||.::...|::
Mouse   590 LKEWSLVLYGTSVQPY------SPTNEFPKVER 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	26/83 (31%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	156/296 (53%)
		Peptidase_S8	187..459	CDD:278510	147/272 (54%)
		Peptidases_S8_S53	<409..485	CDD:299169	42/75 (56%)
		P_proprotein	534..621	CDD:279782	42/90 (47%)
Pcsk5	NP_001177412.1	S8_pro-domain	40..116	CDD:293079	33/109 (30%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	128..422	CDD:173789	156/300 (52%)
		Peptidase_S8	164..447	CDD:278510	153/288 (53%)
		P_proprotein	507..597	CDD:279782	42/90 (47%)
		Cell attachment site. /evidence=ECO:0000255	521..523		1/1 (100%)
		FU 1	632..682
		FU	637..687	CDD:238021
		CRM (Cys-rich motif)	638..1753
		FU	690..739	CDD:238021
		Furin-like_2	695..786	CDD:292535
		FU	781..825	CDD:214589
		GF_recep_IV	786..906	CDD:291509
		FU	835..880	CDD:214589
		FU	885..928	CDD:214589
		FU	931..980	CDD:214589
		FU	1036..1078	CDD:214589
		Furin-like_2	1043..1130	CDD:292535
		FU	1128..1165	CDD:214589
		FU	1211..1256	CDD:238021
		Furin-like_2	1214..1305	CDD:292535
		FU	1301..1343	CDD:214589
		Furin-like_2	1357..1445	CDD:292535
		FU	1397..1446	CDD:238021
		FU	1491..1535	CDD:214589
		GF_recep_IV	1496..1611	CDD:291509
		FU	1546..1593	CDD:238021
		FU	1594..1644	CDD:238021
		GF_recep_IV	1595..1712	CDD:291509
		FU	1642..1684	CDD:214589
		FU	1694..1736	CDD:214589
		AC 1	1825..1844
		AC 2	1856..1877
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.780