DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amon and Pcsk1

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_038656.1	Gene:	Pcsk1 / 18548	MGIID:	97511	Length:	753	Species:	Mus musculus

Alignment Length:	605	Identity:	266/605 - (43%)
Similarity:	364/605 - (60%)	Gaps:	41/605 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VRFRRGVDNSFAHD----------VADKYGFDNLGPLVGADGHEYHFKHRTLPHARSRRSLTH-T 99
            |:.:|...|.:|.:          :|::.|:|.||.:...:.| |.|||::.|. |||||..| |
Mouse    25 VKAKRQFVNEWAAEIPGGQEAASAIAEELGYDLLGQIGSLENH-YLFKHKSHPR-RSRRSALHIT 87

  Fly   100 RALKSHPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPMQWYLKNT 164
            :.|.....|..|.||...:|.||.::      .....||.           .||.:..||||::|
Mouse    88 KRLSDDDRVTWAEQQYEKERSKRSVQ------KDSALDLF-----------NDPMWNQQWYLQDT 135

  Fly   165 GQNGGKVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRY 229
            .......:|||:|...|.:|||||.|...::|||:::.|.|:..||:.||||||:.||..|:|||
Mouse   136 RMTAALPKLDLHVIPVWEKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRY 200

  Fly   230 TDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIY 294
            .....|.||||||||:|...:|..|||||||:||:.|||||| ..:||.|||:|:|..|..:.||
Mouse   201 DLTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLD-GIVTDAIEASSIGFNPGHVDIY 264

  Fly   295 SASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGEE-DDCNCDGYAASMWTI 358
            ||||||.||||||:||.....:|...||.:||.|.|:|:|||||:||.: |:|:||||..|::||
Mouse   265 SASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTI 329

  Fly   359 SINSAINDGQNAHYDESCSSTLASTFSNGAKDPNTGVATTDLYGKCTTTHSGTSAAAPEAAGVFA 423
            ||:||...|.:..|.|.||||||:::|:| ...:..:.:.||:..||.||:||||:||.|||:||
Mouse   330 SISSASQQGLSPWYAEKCSSTLATSYSSG-DYTDQRITSADLHNDCTETHTGTSASAPLAAGIFA 393

  Fly   424 LALEANPQLTWRDIQHLTVLTSKRNSLFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLS-- 486
            |||||||.|||||:|||.|.||:.:.|  |.|. .|..||.||..|..||||:|:|.|:|.|:
Mouse   394 LALEANPNLTWRDMQHLVVWTSEYDPL--ASNP-GWKKNGAGLMVNSRFGFGLLNAKALVDLADP 455

  Fly   487 KQWHSVPPRYHCEAGELT-QPQAIVMGRSLFWEIKTDACKGTDTEVNYLEHVQAVISANASRRGD 550
            :.|.:||.:..|...:.. :|:|:.....:..||.|.||:|.:..:..|||||...:...|||||
Mouse   456 RTWRNVPEKKECVVKDNNFEPRALKANGEVIVEIPTRACEGQENAIKSLEHVQFEATIEYSRRGD 520

  Fly   551 LELFLTSPMGTKSMILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRH-GNL 614
            |.:.|||.:||.:::|:.|..|.. .:||..|.||:.|:|||.|.|||.|:....|.:.:: |.:
Mouse   521 LHVTLTSAVGTSTVLLAERERDTS-PNGFKNWDFMSVHTWGENPVGTWTLKITDMSGRMQNEGRI 584

  Fly   615 LEWSLVLHGTKEAPYRTLHP 634
            :.|.|:||||...|.....|
Mouse   585 VNWKLILHGTSSQPEHMKQP 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	28/86 (33%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	160/296 (54%)
		Peptidase_S8	187..459	CDD:278510	149/272 (55%)
		Peptidases_S8_S53	<409..485	CDD:299169	46/75 (61%)
		P_proprotein	534..621	CDD:279782	37/87 (43%)
Pcsk1	NP_038656.1	S8_pro-domain	34..110	CDD:374560	25/77 (32%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	121..415	CDD:173789	159/306 (52%)
		P_proprotein	504..591	CDD:366670	37/87 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	633..663
		Proho_convert	715..751	CDD:371942
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R643
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850