DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amon and kpc-1

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_492974.2	Gene:	kpc-1 / 173051	WormBaseID:	WBGene00002232	Length:	692	Species:	Caenorhabditis elegans

Alignment Length:	649	Identity:	285/649 - (43%)
Similarity:	387/649 - (59%)	Gaps:	58/649 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LAPFLLLHWASAGAG-------GGAGGSGAGLSGP--AVFTSSFLVRFRRG-VDNSFAHDVADKY 64
            ||.||||..||.|:.       .....:.:.::.|  ..:|:.:.||...| |:.  |:.:|:||
Worm    19 LALFLLLGSASLGSAHIDEEFEDDVTTTISSIASPMRRTYTNEWAVRIAGGKVEE--ANRLANKY 81

  Fly    65 GFDNLGPLVGADGHEYHFKHRTLPHARSRRSLTHTRALKSHPAVHT-----AVQQPGFKRVKRGL 124
            |:.||||::  .|.||:........:||.|.   ||:|.::...|.     ..||...:|||||.
Worm    82 GYTNLGPII--PGDEYYLFRDDRKKSRSSRK---TRSLSANQLQHEEDVMWMEQQVAKRRVKRGY 141

  Fly   125 RPAVPAIHGMKFDLKVGE-----------GNRIDEEPTDPYFPMQWYLKNTGQ--NGGKVRLDLN 176
            |    .|.....|..:.|           .||...:|.||.:...||| |.|:  :....|:|.|
Worm   142 R----RIRRHTDDNDIFEEDDDGTQISKSRNRKHPDPNDPLWTDMWYL-NRGEHHSDSTTRMDHN 201

  Fly   177 VQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRC 241
            |:.||..|.|||.|...|:|||::..|||:..||:..||||.:..|..|.|||.....|.|||||
Worm   202 VKEAWDLGYTGKGVVVTILDDGLERTHPDISPNYDERASYDVNDRDNDPMPRYEFSDENRHGTRC 266

  Fly   242 AGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASWGPTDDGKT 306
            ||||||..:|.:|.||:||::.|.||||||.. :||.:||.|:||....|.||||||||.|||:|
Worm   267 AGEVAAIFNNSLCIVGIAYNANIGGIRMLDGD-VTDAVEAASVGHNADYIDIYSASWGPDDDGRT 330

  Fly   307 VDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGEE-DDCNCDGYAASMWTISINSAINDGQNA 370
            ||||...|..|..:|:..||.|.|:|:|||||:||:: |.||||||..|::|:||:||..:|...
Worm   331 VDGPAKLTRSAFEKGITMGRKGKGSIFVWASGNGGKDADSCNCDGYTNSIYTLSISSATENGNIP 395

  Fly   371 HYDESCSSTLASTFSNGAKDPNTG---VATTDLYGKCTTTHSGTSAAAPEAAGVFALALEANPQL 432
            .|.|:||||||:|:|:||    ||   :.||||:..||..|:||||:||.|||:.||||||||.|
Worm   396 WYSEACSSTLATTYSSGA----TGEKMILTTDLHHACTNMHTGTSASAPLAAGIVALALEANPNL 456

  Fly   433 TWRDIQHLTVLTSKRNSLFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSVPPRYH 497
            ||||:||:.:.|:|..:|    ....||.||||...:|.||:|::||||||.|:|.|..|..::.
Worm   457 TWRDLQHIVIRTAKPINL----RAGDWTTNGVGRNVSHSFGYGLMDAGAMVKLAKIWKKVDEQHR 517

  Fly   498 CEAGELTQPQAIVMGRSLFWEIKTDACKG--TDTEVNYLEHVQAVISANASRRGDLELFLTSPMG 560
            |.....::.:.|..|..|..::.:|.|.|  .:.:|:|:|||||:::..|.:||||:::||||.|
Worm   518 CRQFYPSRYKNIPNGNRLQLQLYSDGCYGGADENKVSYVEHVQAIVTLKAPKRGDLQIYLTSPSG 582

  Fly   561 TKSMILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRHGNLLEWSLVLHGT 624
            |||.:|::||.|.. |.|||.|.|||||:|||...|.|.||  .::.......|::|.|||:||
Worm   583 TKSTLLTKRARDTS-RSGFTDWAFMTTHNWGEQAAGLWILE--IDNDGWDDAELVKWELVLYGT 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	27/84 (32%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	161/301 (53%)
		Peptidase_S8	187..459	CDD:278510	147/275 (53%)
		Peptidases_S8_S53	<409..485	CDD:299169	43/75 (57%)
		P_proprotein	534..621	CDD:279782	42/86 (49%)
kpc-1	NP_492974.2	S8_pro-domain	61..139	CDD:318632	27/84 (32%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	174..470	CDD:173789	161/301 (53%)
		P_proprotein	556..640	CDD:307572	42/86 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R643
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950