DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amon and Pcsk5

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_038965620.1	Gene:	Pcsk5 / 116548	RGDID:	620326	Length:	1878	Species:	Rattus norvegicus

Alignment Length:	683	Identity:	280/683 - (40%)
Similarity:	370/683 - (54%)	Gaps:	111/683 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 WSW-----------------LLAPFLL---------LHWASAGAGGGAGGSGAGLSGPAVFTSSF 44
            |.|                 |||..||         .|||...|||.|.
  Rat     3 WGWGSRCCRPGRRDLLCVLALLAGCLLPVCRTRVYTNHWAVKIAGGFAE---------------- 51

  Fly    45 LVRFRRGVDNSFAHDVADKYGFDNLGPLVGADGHEYHFKH-RTLPHARSRRSLTHTRALKS---- 104
                        |..:|.||||.|:|. :||....|||.| ||:     :||:..:|...|
  Rat    52 ------------ADRIASKYGFINVGQ-IGALKDYYHFYHSRTI-----KRSVLSSRGTHSFISM 98

  Fly   105 HPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPMQWYLKNTGQNGG 169
            .|.|....||...||.||            .:||...:....:    ||.:|..||: :...|..
  Rat    99 EPKVEWIQQQVVKKRTKR------------DYDLSRAQSTYFN----DPKWPSMWYM-HCSDNTH 146

  Fly   170 KVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDWF 234
            ..:.|:|::.||.:|.||||:...|:|||::..||||..||:|.||.|.:.||..|.|||.....
  Rat   147 PCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNE 211

  Fly   235 NSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASWG 299
            |.|||||||||||..:|..|.||:|:::||.|:||||.. :||::||.|:.:.|..:||||||||
  Rat   212 NKHGTRCAGEVAATANNSHCTVGIAFNAKIGGVRMLDGD-VTDMVEAKSVSYNPQHVHIYSASWG 275

  Fly   300 PTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGG-EEDDCNCDGYAASMWTISINSA 363
            |.|||||||||...|.:|...||..||.|||:::|||||:|| .:|.|:||||..|::||||:|.
  Rat   276 PDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISST 340

  Fly   364 INDGQNAHYDESCSSTLASTFSNGAKDPNTGVATTDLYGKCTTTHSGTSAAAPEAAGVFALALEA 428
            ...|:...|.|.||||||:|:|:| :..:..:.||||..:||..|:||||:||.|||:.||||||
  Rat   341 AESGKKPWYLEECSSTLATTYSSG-ESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEA 404

  Fly   429 NPQLTWRDIQHLTVLTSKRNSLFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSVP 493
            ||.|||||:||:.|.||:...|    |...|..|..|.:.:||:|||::||.|||..:::|.:||
  Rat   405 NPFLTWRDVQHVIVRTSRAGHL----NANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVP 465

  Fly   494 PRYHCEAG-----ELTQPQAIVMGRSLFWEIKTDACK-GTDTEVNYLEHVQAVISANASRRGDLE 552
            .::.|...     :..:|.:.|  ||::   |...|. ..:..|||||||...|:....|||||.
  Rat   466 QQHVCVESTDRQIKTIRPNSAV--RSIY---KASGCSDNPNHHVNYLEHVVVRITITHPRRGDLA 525

  Fly   553 LFLTSPMGTKSMILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRH----GN 613
            ::||||.||:|.:|:.|..|.. .:||..|.|||.|.|||...|.|.||......|.|:    |.
  Rat   526 IYLTSPSGTRSQLLANRLFDHS-MEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGK 589

  Fly   614 LLEWSLVLHGTKEAPYRTLHPSSPHSKLAIVKK 646
            |.||||||:||...||      ||.::...|::
  Rat   590 LKEWSLVLYGTSVQPY------SPTNEFPKVER 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	26/83 (31%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	156/296 (53%)
		Peptidase_S8	187..459	CDD:278510	147/272 (54%)
		Peptidases_S8_S53	<409..485	CDD:299169	42/75 (56%)
		P_proprotein	534..621	CDD:279782	42/90 (47%)
Pcsk5	XP_038965620.1	S8_pro-domain	40..116	CDD:406785	33/109 (30%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	128..422	CDD:173789	156/300 (52%)
		P_proprotein	507..597	CDD:396185	42/90 (47%)
		GF_recep_IV	637..751	CDD:405525
		VSP	674..>1063	CDD:146106
		GF_recep_IV	889..995	CDD:405525
		VSP	1003..>1324	CDD:146106
		VSP	1293..>1618	CDD:146106
		FU	1642..1684	CDD:214589
		FU	1694..1737	CDD:214589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820