DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amon and pcsk7

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_002932953.2	Gene:	pcsk7 / 100492320	XenbaseID:	XB-GENE-950061	Length:	755	Species:	Xenopus tropicalis

Alignment Length:	639	Identity:	225/639 - (35%)
Similarity:	318/639 - (49%)	Gaps:	98/639 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TWSWLLAPFLLLHWASAGAGGGAGGSGAGLSGPAVFTSSFLVRFRRGVDNSFAHDVADKYGFDNL 69
            ||:        :|..|:|:.|                       ::...::||..::...|..|.
Frog    44 TWA--------VHLDSSGSSG-----------------------QKEKMDAFAEQLSRSTGLQNR 77

  Fly    70 GPLVGADGHEYHFKHR-TLPHARSRRSLTHTRALKSHPAVHTAVQQPGFKRVKRGLRPAVPAIHG 133
            | ::|.....|.|.:| ::......|...| .....|..|....:|...||.||.|.
Frog    78 G-VIGELKDHYLFAYRGSIQCQEDARRKAH-ELFTQHEGVRWYSEQKLLKRSKRSLH-------- 132

  Fly   134 MKFDLKVGEGNRIDEEPTDPYFPMQWYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTAIMDDG 198
              |:              ||.:|.||:|.|....|    :|:||...|.:.:||:.||..::|||
Frog   133 --FN--------------DPKYPQQWHLHNARNPG----MDINVTGVWERNVTGRGVTVVVVDDG 177

  Fly   199 VDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSK 263
            |.:...|::.||:.|.|||.:||||.|.|.......|.||||||||:||..:|..|.||||:.|:
Frog   178 VQHTIQDIQPNYSPEGSYDLNSNDPDPMPHPDGGSDNRHGTRCAGEIAAVPNNSFCAVGVAFGSR 242

  Fly   264 IAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNG 328
            |||||:||.| :||.:||.:.........|||.||||.|||||||||......|:..||..||.|
Frog   243 IAGIRVLDGP-LTDSMEAIAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRKG 306

  Fly   329 LGNIYVWASGDGGE-EDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAKDPN 392
            .|:|:|.|||:||: .|:||.||||.|::|::|.:....|:...|.|.|:|.||.|||:|.|...
Frog   307 FGSIFVVASGNGGQFSDNCNYDGYANSIYTVTIGAVNEAGKMPFYAEECASMLAVTFSSGDKLMR 371

  Fly   393 TGVATTDLYGK----CTTTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRNSLFDA 453
            : :.|:|...:    ||..|:|||||||.|||:.||.|:..|.||||||||:.|.|:.:..
Frog   372 S-IVTSDWNLQKGTGCTEGHTGTSAAAPIAAGMIALMLQVRPCLTWRDIQHIIVFTATKYE---- 431

  Fly   454 KNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSVP-------PRYHCEAGELTQPQAIVM 511
            ..:..|..||.|...:|..|||:|:|..:...:|.|.|||       |.:.      .:.|..:|
Frog   432 DRQAAWETNGAGFSHSHQHGFGLLNAWRLTNAAKVWESVPYLASYISPVFK------ERKQIPLM 490

  Fly   512 GRSL--FWEIKTDACKGTDTEVN---YLEHVQAVISANASRRGDLELFLTSPMGTKSMILSRRAN 571
            ..:|  :|.:.|     .|..::   .||||...::.....||:||:.|..|.|..|:|.:.|..
Frog   491 PNTLEVYWNVTT-----ADLHLSGMKTLEHVAVTVTIAHPCRGNLEIRLFCPSGMSSLIGATRRI 550

  Fly   572 DDDHRDGFTKWPFMTTHSWGEYPQGTWKL-EARFNSPQTRHGNLLEWSLVLHGT 624
            |.| .:||:.|.|.|...|||..:||::: .:.......|.|.|.:|.|.|:|:
Frog   551 DMD-PNGFSDWTFSTVRCWGESAEGTYRMVVSDIGDESLRPGVLQQWQLTLYGS 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	16/79 (20%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	144/300 (48%)
		Peptidase_S8	187..459	CDD:278510	131/276 (47%)
		Peptidases_S8_S53	<409..485	CDD:299169	34/75 (45%)
		P_proprotein	534..621	CDD:279782	31/87 (36%)
pcsk7	XP_002932953.2	S8_pro-domain	44..129	CDD:374560	22/117 (19%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	133..428	CDD:173789	145/314 (46%)
		P_proprotein	513..600	CDD:366670	31/87 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R643
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.040