DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amon and pcsk6

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_017947964.1	Gene:	pcsk6 / 100485543	XenbaseID:	XB-GENE-979058	Length:	917	Species:	Xenopus tropicalis

Alignment Length:	616	Identity:	268/616 - (43%)
Similarity:	369/616 - (59%)	Gaps:	44/616 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VFTSSFLVRFRRGVDNSFAHDVADKYGFDNLGPLVGADGHEYHFKH-RTLPHARSRRSLTHTRAL 102
            ||::.:.||...|.:  .|.::|.:||:.:||.:...:.: |||.| ||:..:......||: .|
Frog    24 VFSNHWAVRIPGGPE--VAAELAAQYGYLSLGQIGNLENY-YHFYHSRTIKRSTYASRGTHS-FL 84

  Fly   103 KSHPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPMQWYLKNTGQN 167
            :.||.|....||...|||||.:|.               :.|.::.  .||.:|..||| :....
Frog    85 RMHPKVEWMQQQEVKKRVKRHVRT---------------DPNLVNF--NDPIWPNMWYL-HCSDK 131

  Fly   168 GGKVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDD 232
            ..:.|.::||.:||.:|.|||||..:|:||||:..||||..||:..||:|.:.:|..|.|||...
Frog   132 SSRCRSEMNVMSAWQRGYTGKNVVVSILDDGVEKNHPDLIQNYDPHASHDVNGDDQDPSPRYDAS 196

  Fly   233 WFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSAS 297
            ..|.|||||||||||:.:|..|.||:||:::|.||||||.. :||::||.|:|..|..|.|||:|
Frog   197 NENKHGTRCAGEVAASANNSHCIVGIAYNARIGGIRMLDGD-VTDVVEAKSLGVRPDYIDIYSSS 260

  Fly   298 WGPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGEEDD-CNCDGYAASMWTISIN 361
            |||.|||||||||.....:|...|:.:||.|||:|:|||||:||.|.| |:||||..|::||||:
Frog   261 WGPDDDGKTVDGPGPLARKAFEDGIKKGRKGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISIS 325

  Fly   362 SAINDGQNAHYDESCSSTLASTFSNGAKDPNTGVATTDLYGKCTTTHSGTSAAAPEAAGVFALAL 426
            |...:|....|.|.|:||||:|:|:||..... :.||||...||..|:|||.:||..|||.||||
Frog   326 STTENGYKPWYLEECASTLATTYSSGAFYERK-IVTTDLRQGCTDDHTGTSVSAPMVAGVIALAL 389

  Fly   427 EANPQLTWRDIQHLTVLTSKRNSLFDAKNRFHWTMNGVG------LEFNHLFGFGVLDAGAMVTL 485
            ||||.|.|||:|||.|.||:...|    ....|..||.|      :.|:||:|||::||.|||..
Frog   390 EANPVLNWRDVQHLLVKTSRSVHL----RAPDWKTNGAGRKGQKRMWFSHLYGFGLVDADAMVVE 450

  Fly   486 SKQWHSVPPRYHCEAGELTQPQAIVMGRSLFWEIKTDAC-KGTDTEVNYLEHVQAVISANASRRG 549
            :|:|.:|||::.|......:|:.|...:.:....:|:|| ......|.|||||...::.:..|||
Frog   451 AKKWRTVPPQHVCIGASDRRPRFIRAVQLIRTTTQTNACVDNAGHYVAYLEHVVVRVTISHPRRG 515

  Fly   550 DLELFLTSPMGTKSMILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRH--- 611
            ||:::|.||.||||.:|::|..|..: :||..|.|||.|.|||..:|.|.||...:|.|.|:
Frog   516 DLQIYLISPSGTKSQLLAKRTFDSSN-EGFKNWEFMTVHCWGEKAEGEWTLEIHDSSSQLRNPEI 579

  Fly   612 -GNLLEWSLVLHGTKEAPYRTLHPSSPHSKL 641
             |.|.||:|:.:||.|.||.  |..:.||::
Frog   580 QGKLKEWTLIFYGTSEHPYN--HIGTQHSRI 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	26/79 (33%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	157/296 (53%)
		Peptidase_S8	187..459	CDD:278510	146/272 (54%)
		Peptidases_S8_S53	<409..485	CDD:299169	42/81 (52%)
		P_proprotein	534..621	CDD:279782	41/90 (46%)
pcsk6	XP_017947964.1	S8_pro-domain	28..104	CDD:374560	26/79 (33%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	115..409	CDD:173789	157/298 (53%)
		P_proprotein	500..590	CDD:366670	41/90 (46%)
		GF_recep_IV	642..761	CDD:373332
		FU	743..785	CDD:214589
		FU	792..834	CDD:214589
		Furin-like_2	798..880	CDD:374219
		PLAC	890..913	CDD:370061
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010