DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amon and tpp2

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_005168067.1	Gene:	tpp2 / 100331669	ZFINID:	ZDB-GENE-121214-290	Length:	1263	Species:	Danio rerio

Alignment Length:	486	Identity:	99/486 - (20%)
Similarity:	154/486 - (31%)	Gaps:	136/486 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 SHGTRCAGEVAAA------RDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEA-----NSMGHEPH 289
            :|||..| .:||.      ..||:.........||...|:......|.||.|     |      :
Zfish   263 AHGTHVA-SIAAGHFPDEPERNGVAPGAQILALKIGDTRLSTMETGTGLIRAMIEVIN------Y 320

  Fly   290 KIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGEEDDC----NCDG 350
            |..:.:.|:     |:....|.:.   .|.:.:.|.......::|.::|:.|   .|    .|.|
Zfish   321 KCDLVNYSY-----GEATHWPNSG---RICEVITEAVQKYNVMFVSSAGNNG---PCLTTVGCPG 374

  Fly   351 YAASMWTISINSAIN-DGQNAHY--------------------DESCSSTLASTFSNGAKDPNTG 394
            ...|. .|.:.:.:. |...|.|                    |.:...::::.....|..||..
Zfish   375 GTTSS-VIGVGAYVTPDMMVAEYSLREKLPPNQYTWSSRGPCTDGALGVSISAPGGAIASVPNWT 438

  Fly   395 VATTDLYGKCTTTHSGTSAAAPEAAGVFALALEANPQ---------------LTWRDIQHLTVLT 444
            :..|.|.       :|||.::|.|.|..||.|....|               .|.:.::.:.|.
Zfish   439 LRGTQLM-------NGTSMSSPNACGGIALVLSGLKQNGLRPTVPAVRRALENTAQKVEEIEVF- 495

  Fly   445 SKRNSLFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAM--VTLSKQWHSVPPRYHCEAGELTQPQ 507
            ::.:.:...:..|.:.|....|..:.| ||.| .||:.  :.|....|...|..|....|...|:
Zfish   496 AQGHGIIQVERAFDYLMQHNSLASSSL-GFSV-SAGSQRGIYLRDATHVTAPSDHGVGIEPIFPE 558

  Fly   508 --------------AIVMGRSLFWEIKTDACKGTDTEVNYLEHVQAVISANASRRG--------- 549
                          |:|...|  |.    .|......:|...||...|.....|.|
Zfish   559 NTENAARISLQLHLALVCNAS--WV----QCPSHLELMNQCRHVNVRIDPQGLREGLHYTEVCGY 617

  Fly   550 DLELFLTSPMGTK--SMILSRRAND---------DDH-RDGFTKWPFMTTHSWGEYPQGTWKLEA 602
            |.......|:...  ::|:..:.:|         |.| |.|..:..|:|.      |||....|.
Zfish   618 DTTALSAGPLFRVPITVIIPTKVSDSRSQELSFTDVHFRPGQIRRHFITV------PQGASWAEI 676

  Fly   603 RFNSPQTRHGNLLEWSLVLHG---TKEAPYR 630
            ..    |.|...:....|||.   .|:..||
Zfish   677 SL----TSHTGDVSSKFVLHAVHLVKQRAYR 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	51/260 (20%)
		Peptidase_S8	187..459	CDD:278510	52/273 (19%)
		Peptidases_S8_S53	<409..485	CDD:299169	21/92 (23%)
		P_proprotein	534..621	CDD:279782	21/107 (20%)
tpp2	XP_005168067.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	14..489	CDD:173796	50/251 (20%)
		Peptidase_S8	237..500	CDD:278510	51/263 (19%)
		TPPII	778..961	CDD:289357
		TPPII_N	<1033..1079	CDD:289360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900