Protein Alignment amon and pcsk9

DIOPT Version :9

• Sequence 1: NP_477318.1
• Gene: amon / 43215
• FlyBaseID: FBgn0023179
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: XP_003200725.1
• Gene: pcsk9 / 100150316
• ZFINID: ZDB-GENE-060927-1
• Length: 667
• Species: Danio rerio
• Alignment Length: 570
• Identity: 123/570 - (21%)
• Similarity: 179/570 - (31%)
• Gaps: 192/570 - (33%)

  Fly    86 TLPHARSRRSLTHTRALKS---HPAVHTAVQQPG--------------FKRVKRG-----LRPAV 128
            |.|.|.:|.|....|..|.   .|..:..|.:.|              .|..|||     |:...
Zfish    43 TQPEAENRPSAQFYRCTKDAWRMPGQYLVVMRNGTHVNQVERTTRRLSAKAAKRGYLIEILQTYS 107

  Fly   129 PAIHG----MKFD-----LKVGEGNRIDEEPTDPYFPMQWYLKNTGQN------------GGKV- 171
            .|..|    |..|     :|:.....|:|:.:.....:.|.|:...||            |.||
Zfish   108 GAFRGFLVKMSSDVLHMAVKLPHVEYIEEDSSIFAQSIPWNLQRVLQNKHEAGKYSPPNDGAKVG 172

  Fly   172 --RLDLNVQAAWAQGITGKNVTTAIM---------DDGVDYMHPDLKFNYNAEASYDFSSNDPFP 225
              .||.:||      :|.:.|...:|         :|||         ..:.:||.
Zfish   173 VYLLDTSVQ------LTHREVEDRVMVTDFNRVPEEDGV---------RVHRQASQ--------- 213

  Fly   226 YPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLD-QPYMTDLIEANSMGHEPH 289
                    .:||||..|| |.:.||:     |||..:.:..:|:|: |...|  :.....|.|..
Zfish   214 --------CDSHGTHIAG-VISGRDS-----GVARGASVNSVRVLNCQGKGT--VSGALAGLEYI 262

  Fly   290 KIHIYSASWGPT--------DDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGEEDDC 346
            :..:.|....|.        ...:|:    |...|.||:.        |.:.:.|:|:  ..||.
Zfish   263 QSSLASQPVSPVILLLPFVGGFSRTL----NTACRKIVES--------GAVLIAAAGN--YNDDA 313

  Fly   347 NCDGYAASMWTISINSA------INDGQNAHYDESCSSTLASTFSNGAKDPNTGV--ATTDLYGK 403
            .....|:....|::.:.      :|.|........|....|         |...:  |::|. ..
Zfish   314 CLYSPASEPEVITVGAVNFADQPLNRGTTGTNVGRCVDVFA---------PGDDIISASSDC-PT 368

  Fly   404 CTTTHSGTSAAAPEAAGVFALALEANPQLTWRDI-QHLTVLTSKRNSLFDAKNRFH---WTMNGV 464
            |.||.||||.||...|||.|:.|...|..:..:: |.|               |:|   ..:|..
Zfish   369 CFTTKSGTSQAAAHVAGVAAVLLNLRPNSSSAEVLQQL---------------RYHSVKQVINPE 418

  Fly   465 GLEFNHLFGFGVLDAGAMVTLSKQWHSVPPRYHCEAGELTQPQAIVMGRSLFWEIKTDACKGTDT 529
            .|...|.     |....||.                 .|..|.:.:.|..|.       |:...:
Zfish   419 SLPVMHR-----LTTPNMVV-----------------ALPDPTSTLTGEDLL-------CRSVWS 454

  Fly   530 EVNYLEHVQAVISANASR-RGDLELFLTSPMGTKSMILSRRANDDDHRDG 578
            |    .....|.|...|| |...|:...|......|....|.   :.|||
Zfish   455 E----RSASPVFSTAVSRCRSTEEMLSCSSFSDNGMRAGERV---EERDG 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	11/52 (21%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	75/337 (22%)
		Peptidase_S8	187..459	CDD:278510	65/301 (22%)
		Peptidases_S8_S53	<409..485	CDD:299169	22/79 (28%)
		P_proprotein	534..621	CDD:279782	12/46 (26%)
pcsk9	XP_003200725.1	Inhibitor_I9	68..138	CDD:283552	14/69 (20%)
		Peptidases_S8_PCSK9_ProteinaseK_like	147..412	CDD:173790	77/343 (22%)
		Peptidase_S8	167..406	CDD:278510	70/302 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900