DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amon and pcsk2

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001090660.1	Gene:	pcsk2 / 100036632	XenbaseID:	XB-GENE-960013	Length:	639	Species:	Xenopus tropicalis

Alignment Length:	647	Identity:	388/647 - (59%)
Similarity:	453/647 - (70%)	Gaps:	32/647 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WLLAPFLLLHWASAGAGGGAGGSGAGLSGPAVFTSSFLVRFRRGVDNSFAHDVADKYGFDNLGPL 72
            |:||. |:||.||....          :|..|.|..|||..|.| ..:.|..:|.:|||.....|
Frog     9 WMLAA-LVLHLASVLVS----------AGRPVLTDHFLVDLREG-GEAEAKQLAAEYGFSGTRKL 61

  Fly    73 VGADGHEYHFKHRTLPHARSRRSLTHTRALKSHPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKFD 137
            ..... .|||.......:|||||:...:.|...|.::..|||.||.|.|||.|           |
Frog    62 PFTQS-LYHFYGNGKTTSRSRRSVNKKKHLAMDPKINKVVQQEGFHRKKRGYR-----------D 114

  Fly   138 LKVGEGNRIDEEPTDPYFPMQWYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYM 202
            :     |.||....||.|..||||.||||..|...|||||..||..|.||:.||.||||||:||:
Frog   115 I-----NDIDINMNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGRGVTIAIMDDGIDYL 174

  Fly   203 HPDLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGI 267
            ||||..|||||||||||||||:|||||||||||||||||||||:||.:|.||||||||:||:|||
Frog   175 HPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGI 239

  Fly   268 RMLDQPYMTDLIEANSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNI 332
            ||||||:|||:|||:|:.|.|..|.|||||||||||||||||||..|::|:..|||:||.|.|:|
Frog   240 RMLDQPFMTDIIEASSISHMPQVIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKGRGGKGSI 304

  Fly   333 YVWASGDGGEEDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAK-DPNTGVA 396
            |||||||||..|||||||||:||||||||||||||:.|.||||||||||||||||.| :|..|||
Frog   305 YVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVA 369

  Fly   397 TTDLYGKCTTTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRNSLFDAKNRFHWTM 461
            ||||||.||..|||||||||||||||||||||||.|||||:|||||||||||.|.|..::  |..
Frog   370 TTDLYGNCTLRHSGTSAAAPEAAGVFALALEANPGLTWRDLQHLTVLTSKRNQLHDEVHK--WRR 432

  Fly   462 NGVGLEFNHLFGFGVLDAGAMVTLSKQWHSVPPRYHCEAGELTQPQAIVMGRSLFWEIKTDACKG 526
            ||||||||||||:|||||||||.::.:|.:||.|:||..|.:.:|:.|.....|...:.||||:|
Frog   433 NGVGLEFNHLFGYGVLDAGAMVKMANEWKTVPERFHCIGGAIQEPRRIPSDGKLILTLSTDACEG 497

  Fly   527 TDTEVNYLEHVQAVISANASRRGDLELFLTSPMGTKSMILSRRANDDDHRDGFTKWPFMTTHSWG 591
            .:..|.|||||||||:.|::|||||.:.:||||||||::||||..|||.:.||.||||||||:||
Frog   498 KENFVRYLEHVQAVITVNSTRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWG 562

  Fly   592 EYPQGTWKLEARFNSPQTRHGNLLEWSLVLHGTKEAPYRTLHPSSPHSKLAIVKKAHEDKKM 653
            |.|:|||.||..|.......|.|.||:|:||||:.|||.........||||:.||...::::
Frog   563 EDPRGTWVLEVGFVGSMPEKGVLKEWTLMLHGTQSAPYIDQIVRDYQSKLAMSKKEELEEEL 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	27/78 (35%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	230/296 (78%)
		Peptidase_S8	187..459	CDD:278510	215/272 (79%)
		Peptidases_S8_S53	<409..485	CDD:299169	62/75 (83%)
		P_proprotein	534..621	CDD:279782	54/86 (63%)
pcsk2	NP_001090660.1	S8_pro-domain	33..110	CDD:374560	27/78 (35%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	123..419	CDD:173789	230/295 (78%)
		P_proprotein	505..592	CDD:366670	54/86 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	453	1.000	Domainoid score	I500
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37640
Inparanoid	1	1.050	753	1.000	Inparanoid score	I558
OMA	1	1.010	-	-		QHG45838
OrthoDB	1	1.010	-	-		D308083at2759
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	1	1.000	-	-		oto104025
Panther	1	1.100	-	-	LDO	PTHR42884
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5187
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080