DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amon and pcsk7

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001307357.1	Gene:	pcsk7 / 100009656	ZFINID:	ZDB-GENE-030131-7293	Length:	709	Species:	Danio rerio

Alignment Length:	633	Identity:	229/633 - (36%)
Similarity:	324/633 - (51%)	Gaps:	80/633 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LAPFLLLHWASAGAGGGAGGSGAGLSGPAVFTSSFLVRFRRGVDNSFAHDVADKYGF---DNLGP 71
            |.|.||| ::|:.:....|.|.|....|...:|:       |..:..|..||...|.   ..:|.
Zfish    12 LYPLLLL-FSSSSSSCAPGRSWAVQLQPDSLSSA-------GSPDLLAQAVAQDVGLRSHGQIGQ 68

  Fly    72 LVG--------ADGHEYHFKHRTLPHARSRRSLTHTRALKSHPAVHTAVQQPGFKRVKRGLRPAV 128
            |.|        |.|.::.:..               .||..||.|....|:...:|.||
Zfish    69 LEGHYLLCQDPAQGEDWRWME---------------AALDRHPHVAWHSQENVLRRSKR------ 112

  Fly   129 PAIHGMKFDLKVGEGNRIDEEPTDPYFPMQWYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTA 193
             ::|   |:              ||.||.||:|.|..:.|    :|:||...|.:.|||..||..
Zfish   113 -SVH---FN--------------DPKFPSQWHLHNDMKRG----MDINVTGVWERNITGAGVTVV 155

  Fly   194 IMDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGV 258
            ::|||:.:...|::.||:.|.|||.:||||.|.|.......|.||||||||:||..:|..|.|||
Zfish   156 VVDDGIQHNLADIQPNYSPEGSYDLNSNDPDPMPHPDGPSDNHHGTRCAGEIAAVSNNSFCAVGV 220

  Fly   259 AYDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVN 323
            ||.|::||||:||.| :||.:||.:.........|||.||||.|||:|||||......|:..||.
Zfish   221 AYGSRVAGIRVLDGP-LTDSMEAIAFNKHYQVNDIYSCSWGPDDDGRTVDGPHPLGKAALQHGVI 284

  Fly   324 EGRNGLGNIYVWASGDGGE-EDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNG 387
            .||.|.|:|::.|||:||: :|:||.||||.|::|::|.:....|:...|.|.|:|.||.|||:|
Zfish   285 AGRKGFGSIFIVASGNGGQNQDNCNYDGYANSIYTVTIGAVDESGRKPTYAEECASMLAVTFSSG 349

  Fly   388 AKDPNTGVATTDLYGK----CTTTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRN 448
             ..|...:.|:|...:    ||:.|:|||||||.|||:.||.|:..|.|:|||:||:...|:.::
Zfish   350 -NTPLRSIVTSDWSLQSGTGCTSGHTGTSAAAPLAAGMVALMLQVRPCLSWRDVQHIITYTATQH 413

  Fly   449 SLFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSVPPRYHCEAGELTQPQAIVMGR 513
            .|     :..|..||.|...:|.:|||:|:|..:|..:|.|.|||.....::..|...:.|....
Zfish   414 DL-----QADWVTNGAGFHHSHKYGFGLLNAWRLVNAAKVWESVPFLVSYQSPVLRVNEVITTST 473

  Fly   514 SL--FWEIKTDACKGTDTEVNYLEHVQAVISANASRRGDLELFLTSPMGTKSMILSRRANDDDHR 576
            :|  .|.:.....:.:..:.  ||||...:|....|||:|::.|..|.|..|:|.:|||.|.|..
Zfish   474 NLTQTWNVSESDLQRSGMQT--LEHVSVTLSIQHPRRGNLQILLLCPSGISSLIGARRALDVDSA 536

  Fly   577 DGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRHGNLLEWSLVLHGT 624
             |.|.|.|.|...|||..:|.:.|....::|.: .|.|..|.|.|:|:
Zfish   537 -GLTDWTFSTVRCWGEQAEGQYSLLIMDDAPLS-SGILKSWKLTLYGS 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	17/89 (19%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	140/300 (47%)
		Peptidase_S8	187..459	CDD:278510	126/276 (46%)
		Peptidases_S8_S53	<409..485	CDD:299169	33/75 (44%)
		P_proprotein	534..621	CDD:279782	34/86 (40%)
pcsk7	NP_001307357.1	S8_pro-domain	31..112	CDD:318632	21/102 (21%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	116..411	CDD:173789	141/314 (45%)
		P_proprotein	494..579	CDD:307572	34/86 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R643
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850