DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amon and pcsk1

DIOPT Version :9

Sequence 1:	NP_477318.1	Gene:	amon / 43215	FlyBaseID:	FBgn0023179	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001131134.1	Gene:	pcsk1 / 100005716	ZFINID:	ZDB-GENE-071009-1	Length:	755	Species:	Danio rerio

Alignment Length:	611	Identity:	271/611 - (44%)
Similarity:	368/611 - (60%)	Gaps:	36/611 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 FTSSFLVRFRRGVDNSFAHDVADKYGFDNLGPLVGADGHEYHFKHRTLPHARSRRSLTH-TRALK 103
            :.:.:.|....||.|  |..:||::|: .|...:||..:.|.||..:.| :|::||..| |:.|.
Zfish    29 YLNEWAVEIPGGVQN--ARSIADEFGY-QLVRQIGALENHYLFKRHSHP-SRTKRSADHITKRLS 89

  Fly   104 SHPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPMQWYLKNTGQNG 168
            ....|..|.||...:|.||       |..|::.     :...:|:...||.:..||||::|..:.
Zfish    90 EDDRVSWAEQQYEKRRAKR-------APLGVEC-----KDCSVDKLFDDPMWNQQWYLQDTRTSS 142

  Fly   169 GKVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDW 233
            ...:|||:|...|.:|||||.|...::|||:::.|.|:..||:..|||||:.|||.|:|||....
Zfish   143 SLPKLDLHVIPVWKKGITGKGVVITVLDDGLEWNHTDIYPNYDPAASYDFNDNDPDPFPRYDSTN 207

  Fly   234 FNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASW 298
            .|.||||||||:|...||..|||||||:||:.|||||| ..:||.|||:|:|:.|..:.||||||
Zfish   208 ENKHGTRCAGEIAMQADNNKCGVGVAYNSKVGGIRMLD-GIVTDAIEASSIGYNPDHVDIYSASW 271

  Fly   299 GPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGEE-DDCNCDGYAASMWTISINS 362
            ||.||||||:||.....:|...|:.:||.|.|:|:|||||:||.: |:|:||||..|::||||:|
Zfish   272 GPNDDGKTVEGPGRLAQKAFEYGIQKGRGGKGSIFVWASGNGGRQGDNCDCDGYTDSLYTISISS 336

  Fly   363 AINDGQNAHYDESCSSTLASTFSNGAKDPNTGVATTDLYGKCTTTHSGTSAAAPEAAGVFALALE 427
            |...|.:..|.|.||||||:.:|:| ...:..:.:.||:.:||.||:||||:||.|||:||||||
Zfish   337 ASQQGLSPWYAEKCSSTLATAYSSG-DYTDQRITSADLHNECTETHTGTSASAPLAAGIFALALE 400

  Fly   428 ANPQLTWRDIQHLTVLTSKRNSLFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLS--KQWH 490
            .||.|||||:|||.|.||:.:.|   .|...|..||.||..|..||||:|:|.|:|.|:  |.|.
Zfish   401 QNPDLTWRDLQHLVVWTSEFDPL---ANNPGWKRNGAGLMVNSRFGFGLLNAKALVDLADPKVWK 462

  Fly   491 SVPPRYHCEAGELT-QPQAIVMGRSLFWEIKTDACKGTDTEVNYLEHVQAVISANASRRGDLELF 554
            .||.:..|...:.| ||:.:.....:..||.|.||.|....|..|||||..:|...:|||||.:.
Zfish   463 HVPEKKQCIVRDETFQPRPLKAAGEISIEIPTKACAGQANSVMSLEHVQVEVSIEYTRRGDLHIT 527

  Fly   555 LTSPMGTKSMILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRH-GNLLEWS 618
            ||||.||.:::|:.|..|.. .:||..|.||:.|:|||.|.|||.|:....|.:..: |.::.|.
Zfish   528 LTSPSGTTTVLLAERERDTS-SNGFRNWAFMSVHTWGENPTGTWILKITDTSGRMENEGQIISWK 591

  Fly   619 LVLHGTKEAPYRTLHPSSPHSKLAIV 644
            |:||||.|.|        .|.|.|.|
Zfish   592 LILHGTSEKP--------EHMKKARV 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amon	NP_477318.1	S8_pro-domain	43..122	CDD:293079	26/79 (33%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..446	CDD:173789	159/296 (54%)
		Peptidase_S8	187..459	CDD:278510	147/272 (54%)
		Peptidases_S8_S53	<409..485	CDD:299169	44/75 (59%)
		P_proprotein	534..621	CDD:279782	38/87 (44%)
pcsk1	NP_001131134.1	S8_pro-domain	32..108	CDD:293079	26/79 (33%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	124..418	CDD:173789	158/295 (54%)
		Peptidase_S8	161..435	CDD:278510	150/278 (54%)
		P_proprotein	507..594	CDD:279782	38/87 (44%)
		Proho_convert	716..752	CDD:288988
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R643
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850