DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plum and FNDC1

DIOPT Version :9

Sequence 1:	NP_001163744.1	Gene:	plum / 43197	FlyBaseID:	FBgn0039431	Length:	1298	Species:	Drosophila melanogaster
Sequence 2:	NP_115921.2	Gene:	FNDC1 / 84624	HGNCID:	21184	Length:	1894	Species:	Homo sapiens

Alignment Length:	1128	Identity:	192/1128 - (17%)
Similarity:	323/1128 - (28%)	Gaps:	475/1128 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   468 INITFD------SRTLTSMFVVYIVRNNPHSWTSFSPMKLNQTSYVVISTDLPVYEP----FALI 522
            :.:|:|      ||.:....:.|     ..|..|...:|:|..:|..:..|:   ||    |.|:
Human    55 LKVTWDPPKDATSRPVEHYNIAY-----GKSLKSLKYIKVNAETYSFLIEDV---EPGVVYFVLL 111

  Fly   523 T--------RVLF----------------------PTTEVRTGTLVPQQMILSSLRSTPVTCCTQ 557
            |        |.::                      |..|..|...||.:.:...:||:
Human   112 TAENHSGVSRPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSS------- 169

  Fly   558 GLMLRPIAVGNDTF-VKWSQGQLENKKY------FILQF-----SINHTHPHPAQLLNGSLQGTL 610
                      :|.. |.|...:|...|.      |:|.:     .:|:.              .|
Human   170 ----------DDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYV--------------PL 210

  Fly   611 TSVEEKADQVRH------HLTEIQPLNQSA-------AATVLRNVEHEDNVVDDTLELEDDIFSL 662
            |. :|:..:::.      ::..:|.:|...       ||...|.:..||.     |::.|||
Human   211 TR-DERTHEIKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDE-----LDVPDDI--- 266

  Fly   663 VVDASVTGILLQRFTRIKMRVLIITTENEFLGQDFRYVQW--KIIENGTSEQSNMPFRLVTRESR 725
                               .|.::::::..       |.|  .::|......::..:.:..||..
Human   267 -------------------SVRVMSSQSVL-------VSWVDPVLEKQKKVVASRQYTVRYREKG 305

  Fly   726 ALAFKFLDSLNETCVLECHTEIQAQMSLPSQDPKCQDRNIANSLLLVTGLKPDTRYNLHFYNCKT 790
            .||                              :...:.|||..:|:..|.|||     .|....
Human   306 ELA------------------------------RWDYKQIANRRVLIENLIPDT-----VYEFAV 335

  Fly   791 RIFYGDID--------EKTEQDPPGTI-SNSKLIKQNG----LKLMWEPPINPNGRVHHYDIRWS 842
            ||..|:.|        ::|.:..|.|. .|..:...||    :...|:......|:|..|.:
Human   336 RISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKVKEYIL--- 397

  Fly   843 LDNVTHEAIVKECTKCSYKFPNVSETAKIH---------VAVRVMGDTGAG-----------APM 887
                ::...:|.....|..:|..:.:|.:.         ..:|.....|.|           ...
Human   398 ----SYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTS 458

  Fly   888 YFDMINNNHTWLKEE------------SESSHSEVYSGIAIGSLLSIACVFLFGLFIIFQQRNFK 940
            ..|:..|.....|.|            :.|.|..|.:..                    |.||.|
Human   459 KADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASP--------------------QGRNAK 503

  Fly   941 -----------ARAQGP-----------------THLTTPTDINFGNLSSASGMPGDSAGGLSGG 977
                       |....|                 |.:|...::  |:...:...|.|:
Human   504 DLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEEL--GSREDSPMSPSDT------- 559

  Fly   978 TLQQDCHEMQTLIPRSRYHIELL----------------------PEHSLEYQ-----TSTAAVA 1015
               ||  :.:||.|.||:...::                      |..||..|     ..:|:.:
Human   560 ---QD--QKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASAS 619

  Fly  1016 VVHLANGNGSVQVARR--------------SDQDGAAQGDLGIAGVHNLSQLPLCGVGGTSPERK 1066
            ..|.|:..|:   :.|              ||:|..|.|.|...|.....:..|      ||.|:
Human   620 PAHHASTQGT---SHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPAL------SPSRQ 675

  Fly  1067 TVQDAMLQEAKAFY------IPYRHTPPNAVALSSSKQCAVPSGSELEVIVPPN--SLPLVTTMP 1123
            : ..::|::..:.:      .|.|.||.:..|...|...|.||.     :.||:  |..|:.|.|
Human   676 S-PSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSR-----LSPPHGGSSRLLPTQP 734

  Fly  1124 GL-GVVGGGGSGGGGVGGSSRRSGSLSSSSASSSS------------------------------ 1157
            .| ..:..||..|.....::..:.|.|:.|:|.||
Human   735 HLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGR 799

  Fly  1158 ----------------------------NGSSKKQF----------------------HTNFVRH 1172
                                        ||.|..:|                      |.....|
Human   800 QAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSH 864

  Fly  1173 SNS----NDGIYLLAEEEAAATLT------PTSEREYAAVCLTNGFK-----------------L 1210
            |:|    :.||:...|:|.....|      |:|.|:    .::.|::                 :
Human   865 SDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQ----PISRGWEDLRRSPQRGASLHRKEPI 925

  Fly  1211 PADVAKSGGGTYNTTNNNN--SSTNTSQKSATAKERQPRGNGNPISFSHNACKVPANGPASVNVN 1273
            |.:...:|..|:.....::  |.....|:|..|..........|.|...:|.  ||..||:.:..
Human   926 PENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHAS--PARPPAARSQQ 988

  Fly  1274 HSSAVKQSWPAATVVHRRAQVDP 1296
            |.|..::..|.     |..|..|
Human   989 HPSVPRRMTPG-----RAPQQQP 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plum	NP_001163744.1	IG_like	170..241	CDD:214653
		IGc2	175..235	CDD:197706
		IG_like	284..356	CDD:214653
		I-set	360..443	CDD:254352
		IGc2	378..435	CDD:197706
		FN3	804..886	CDD:238020	16/106 (15%)
FNDC1	NP_115921.2	FN3	40..120	CDD:214495	16/72 (22%)
		FN3	158..241	CDD:214495	16/114 (14%)
		FN3	261..354	CDD:238020	24/156 (15%)
		FN3	362..452	CDD:238020	14/96 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..500		8/64 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..1271		97/532 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1311..1350
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1444..1515
		FN3	1658..1749	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900