DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plum and si:ch211-57n23.4

DIOPT Version :9

Sequence 1:	NP_001163744.1	Gene:	plum / 43197	FlyBaseID:	FBgn0039431	Length:	1298	Species:	Drosophila melanogaster
Sequence 2:	XP_009292645.2	Gene:	si:ch211-57n23.4 / 799595	ZFINID:	ZDB-GENE-140106-153	Length:	722	Species:	Danio rerio

Alignment Length:	991	Identity:	198/991 - (19%)
Similarity:	313/991 - (31%)	Gaps:	380/991 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 PIYCSWYRNDV-VVEQVSYRKNDFFIYDNGTLRLPTNEKA-------SGEYYCKIEWDESAVISD 149
            ||..:|::|.. ::..:..|..   |..||||.:.:.:|.       :|||||..:.....::|.
Zfish    51 PITVTWHKNGAPLLAGIGSRVK---ILSNGTLLIRSFQKRRDGDATDAGEYYCAAQNHYGMLVSR 112

  Fly   150 RITVEYPVLKRLFPGQQQAANISALENKPLVLS----------CPFLSVPAARFSWYFGNDSL-T 203
            :..|             |.|::......|..:|          |....:|.|..:|...:..| |
Zfish   113 KARV-------------QLASLPKFHTHPESMSVDDGGVARFQCQVNGIPEASITWEKDHVVLGT 164

  Fly   204 NDNSALILTNGTLILRHLRLEQAGKYKCVAQNTFASK-THRQFIWQLQVEPKDATFYPKNEAGIT 267
            :|:...:|..|.|.:..::...||.|:|||.|...:: :|...:               |..|..
Zfish   165 SDDRYTLLPMGILQITGVKKADAGIYRCVASNIANTRYSHEAHL---------------NVTGGV 214

  Fly   268 ETAVSEAQLLPAFQNATVFVPAGGSVLLQCHAVADFVPIV-WYLQPPNNKMVRLSNNSVAYS--- 328
            .....|..:|...||.|:.|..  :.:|:|.|..:..||| |         .||...|:...
Zfish   215 PRTYKEPVILSGPQNLTITVHQ--TAILECIATGNPRPIVSW---------SRLDGRSIGVEGIQ 268

  Fly   329 --------ITNASIARHEGRYSCIT------PLETQNFQVIVTTPPRIVSRLPVEVVY-IGLSRT 378
                    |::.|: :|.|.|.|..      ...|...:::|..||..: :.|..|.. .|.|..
Zfish   269 VLGTGNLMISDVSL-QHSGVYVCAANRPGTRMRRTALGRLVVQAPPEFI-QWPQSVSKPAGGSAV 331

  Fly   379 LTCRAEGHPEPSITWYHNGVHLNSSYTRYISGNE--LHVHSFDSKEEGIYQCVARNVAGEDSATG 441
            .||.|:|.|||.|.|..||..|.......::.|.  |.|....|::|.||||:|.|.||.:.|:.
Zfish   332 FTCVAQGVPEPHIIWLKNGKILTPGDNVKLTNNNSTLAVTRITSEDEAIYQCIAENTAGTNQASA 396

  Fly   442 ELRFNRQLEEVNPLQNIRCYPHSFHSINITFDSRTLTSMFVVYIVRNNPHSWTSFSPMKLNQTSY 506
            .|..:...|          .|.|...:..|..|:|...:           |||.
Zfish   397 RLAVSLAKE----------LPDSPQGLKATALSKTSLQL-----------SWTQ----------- 429

  Fly   507 VVISTDLPVYEPFALITRVLFPTTEVRTGTLVPQQMILSSLRSTPVTCCTQGLMLRPIAVGNDTF 571
                                 |..||                       |.|:      :|....
Zfish   430 ---------------------PPAEV-----------------------TDGI------IGYVLH 444

  Fly   572 VKWSQGQLENKKYFILQFSINHTHPHPAQLLNGSLQGTLTSVEEKADQVRHHLTEIQPLNQSAAA 636
            :: ..|:.|:|:   ||.:::.|          :.|..||:: |.|.....:|....||..|
Zfish   445 IR-KYGESESKE---LQEAVSKT----------TFQHDLTNL-EPATTYSIYLKAYSPLGAS--- 491

  Fly   637 TVLRNVEHEDNVVDDTL---ELEDDIFSLVVDASVTGILLQRFTRIKMRVLIITTENEFLGQDFR 698
                  :....||..||   ......|:..::|:...:|
Zfish   492 ------QQSSTVVSTTLGGVPSPPTFFTKAINATAVQVL-------------------------- 524

  Fly   699 YVQWKIIEN-GTSEQSNMPFRLVTRESRALAFKFLDSLNETCVLECHTEIQAQMSLPSQDPKCQD 762
               |::... |.:|...:.:|.|.                      |.|:|..:.||     |
Zfish   525 ---WELPNKPGKAEGFRLTYRRVP----------------------HGEMQGPIQLP-----C-- 557

  Fly   763 RNIANSLLLVTGLKPDTRYNLHFYNCKTRIFYGDIDEKTEQDPPGTISNSKLIKQNGLKLMWEPP 827
                             ..|.|..:        .:|       .|.:...||:..||
Zfish   558 -----------------HVNAHIIS--------HLD-------AGAVYEVKLVAYNG-------- 582

  Fly   828 INPNGRVHHYDIRWSLDNVTHEAIVKECTKCSYKFPNVSE---TAKIHVAVRVMGDTGAGAPMYF 889
               ||.                      :.||.|..:::|   :||          |.||
Zfish   583 ---NGE----------------------SDCSKKLVSLAEDGTSAK----------TRAG----- 607

  Fly   890 DMINNNHTWLKEES-------ESSHSEVYSGIAIGSLLSIACVFLFGLFIIF-QQRNFKARAQGP 946
                       ||:       |.|.|.:..||.||    :||:....||::| .:|:|..|....
Zfish   608 -----------EEAQCNCRGVEGSVSSIVVGIHIG----MACIIFCVLFLMFGYRRSFLCRKGTQ 657

  Fly   947 THLTTPTDINFGNLSSASGMPGDSAGGLSGGTLQQDCHEMQTLIPRSRYHIELLPEHSLEYQTST 1011
            ...:.|...:.|:....:|:|...                   |.:....|||:|:...:.||..
Zfish   658 DSWSVPQGEDGGHRVQGNGLPKQG-------------------ITQPAQGIELVPQGHNKDQTQC 703

  Fly  1012 AAVAVVHLAN--GNGS 1025
            ..:...|.:|  |.|:
Zfish   704 QVLIEQHPSNLPGTGT 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plum	NP_001163744.1	IG_like	170..241	CDD:214653	19/82 (23%)
		IGc2	175..235	CDD:197706	18/70 (26%)
		IG_like	284..356	CDD:214653	19/89 (21%)
		I-set	360..443	CDD:254352	31/85 (36%)
		IGc2	378..435	CDD:197706	23/58 (40%)
		FN3	804..886	CDD:238020	16/84 (19%)
si:ch211-57n23.4	XP_009292645.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900