DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plum and boc

DIOPT Version :9

Sequence 1:	NP_001163744.1	Gene:	plum / 43197	FlyBaseID:	FBgn0039431	Length:	1298	Species:	Drosophila melanogaster
Sequence 2:	NP_001072742.1	Gene:	boc / 780199	XenbaseID:	XB-GENE-923398	Length:	1065	Species:	Xenopus tropicalis

Alignment Length:	1309	Identity:	244/1309 - (18%)
Similarity:	400/1309 - (30%)	Gaps:	421/1309 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VAQPKNST--ALQPYLQIQKH--AVTRLTISKPHSPYYLPCIPILTPYNHDQDNQPIYCSWYRND 102
            ||||..:.  .:||....||:  :||.....:|.|                     ...||..|.
Frog    24 VAQPGRAPHFLVQPLSTFQKYGGSVTLSCSVEPAS---------------------AIISWQLNG 67

  Fly   103 VVVEQVSYRKNDFFIYDNGTLRLPT-NEKASGEYYCKIEWDESAVISDRITVEYPVLKRLFPGQQ 166
            ..::...      .:...|||.:.: |....|.|.|.......::.|....|....|:......|
Frog    68 AELDLPG------VLVSGGTLVIASLNNDTVGRYQCIARTPVGSISSVPAIVTLANLQDFKSDAQ 126

  Fly   167 QAANISALENKPLVLSCPF-LSVPAARFSWYFGNDSL-TNDNSALILTNGTLILRHLRLEQAGKY 229
            ....:.  |....|::|.. .|.|.|:..:....:.| |:.::.||:.:|.|.:.:...|..|.|
Frog   127 HVIEVD--EGNTAVIACNLPESHPKAQVRYSVKQEWLETSRDNYLIMPSGNLQIVNATQEDEGTY 189

  Fly   230 KCVAQNTFASKTHRQFIWQLQVEPKDATFYPKNEAGITETAVSEAQLLPAFQNATVFVPAGGSVL 294
            ||.|.|              .|..:..|....:...:..:....|:::......|:.|..|.|::
Frog   190 KCAAYN--------------PVTQEVKTSVSSDRLRVRRSTAEAARIIYPPNAQTIIVTKGQSLI 240

  Fly   295 LQCHAVADFVP---IVW-----YLQPPNNKMVRLSNNSVAYSITNASIARHEGRYSCITPLETQN 351
            |:|  ||..:|   |.|     .:...|.....|||     .:.:|:.....|.|:|    ...|
Frog   241 LEC--VASGMPPPRITWAKDGAEVSGHNKTRFLLSN-----LLIDATSEEDSGTYTC----TAGN 294

  Fly   352 -----------FQVIVTTPPRIVSRLPVEVVYIGLSRTLTCRAEGHPEPSITWYHNGVHLNSSYT 405
                       :.|.|..||.:...|...:|..|.|...||..:|:|:||:.|..|...|..|..
Frog   295 GIGEGGSTFIFYNVQVFEPPEVSMELSQPIVTWGQSAKFTCEIKGNPQPSVIWLRNATPLIPSAK 359

  Fly   406 RYISGNELHVHSFDSKEEGIYQCVARNVAGEDSATGELRFNRQLEEVNPLQNIRCYPHSFHSINI 470
            ..:|...|.|.:...::.|:|||:|.|..|...|...|...|....:||.::...      |..:
Frog   360 HKMSRKVLRVINVGPEDGGVYQCMAENEVGSAQALALLITTRAGSFLNPEKDAPT------SSPL 418

  Fly   471 TFDSRTLTSMFVVYIVRNNPHSWTSFSPMKLNQTSYVVISTDLPVYEPFALITRVLFPTTEVRTG 535
            ..|.:.|..      .:..|...|...|.:...:....:..:.||
Frog   419 AEDRQLLLK------AQYKPRPPTPLLPAQCPNSKETALPPEAPV-------------------- 457

  Fly   536 TLVPQQMILSSLRSTPVTCCTQGLMLRPIAVGNDTFVKWSQGQLENKKYFILQFSINHTHPHPAQ 600
                   ||||.|::...  ...|:.||..||....:           ::|::        |..|
Frog   458 -------ILSSPRTSKTD--FYELVWRPRNVGGAPVL-----------FYIIK--------HRKQ 494

  Fly   601 LLNGSLQGTLTSVEEKADQVRHHLTEIQPLNQSAAATVLRNVEHE----------------DNVV 649
            :.|.|.:.|::.|  ...|.|..||::.|.:.........|...|                |.|.
Frog   495 VANSSDEWTVSRV--PGPQHRLTLTKLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPDIVA 557

  Fly   650 DDTLELEDD--------------------------IFSLVVDASVTGILLQRFTRIKMRVLIITT 688
            ...::::.|                          ..|:..:.||....:.|            .
Frog   558 SKEIQIQKDDPGTSTQSSNQSDNNRLSPPEAPDRPTISMASETSVYVTWIPR------------G 610

  Fly   689 ENEFLGQDFRYVQWKIIENG---TSEQSNMPFRL---VTRESRALAFKFLDSLNETCVLECHTEI 747
            ...|..|.||....|:.:.|   .:.:...|.||   :|...:..::||              .:
Frog   611 NGGFPIQSFRVEYKKLKQPGDWILATRDIPPSRLSVEITELEKGTSYKF--------------RV 661

  Fly   748 QAQMSLPSQDPKCQDRNIANSLLLVTGLKPDTRYNLHFYNCKTRIFYGDIDEKTEQDPPGTISNS 812
            :|...|....|     :.|:...:|:|      |:...|.   |...|.....||.....||.
Frog   662 RALNILGESQP-----SAASKPYVVSG------YSNRVYE---RPVTGPYITFTEAINETTIM-- 710

  Fly   813 KLIKQNGLKLMWEPPINPNGRVHHYDIRWSLDNVTHEAIVKECTKCSYKFPNVSETAKIHVAVRV 877
                   ||.|:.|..|.|..:|.:.|.:...:..:::..|:
Frog   711 -------LKWMYTPASNNNTPIHGFYIYYRPTDSDNDSDYKK----------------------- 745

  Fly   878 MGDTGAGAPMYFDMINNNHTWLKEESESSHSEVYSGIAIGSLLSIACVFLFGLFIIFQQRNFKAR 942
                        |::..:..|        ||
Frog   746 ------------DVVEGDRYW--------HS---------------------------------- 756

  Fly   943 AQGPTHLTTPT--DINFGNLSSASGMPGDSAGGLSGGTLQQDCHEMQTLIPRSRYHIELLPEHSL 1005
               .:||...|  ||.         |...:.||.|..:....|.......|||:  ...:|....
Frog   757 ---ISHLQPETSYDIK---------MQCFNEGGESEYSNVMICETKARKSPRSQ--TPAVPSPQP 807

  Fly  1006 EYQTSTAAVAVVHLANGNGSVQVARRSDQDGAAQGDLGIAGVHNLSQLPLCGVGGTSPERKTVQD 1070
            .:.:...||         |:..|||.||......|.||...:..::.:|:|.....|.:::|...
Frog   808 SHSSGKGAV---------GTATVARSSDVPYMIVGVLGSIVLILVAFIPVCLWRAWSKQKQTTDI 863

  Fly  1071 AMLQEAKAFYIPYRHTPPNAVALSSSKQCAVPSGSELEVIVPPNSLPLVTTMPGLGVVGGGGSGG 1135
            |.               |:|..|:||.|         ..:||...:..::..|        .:.|
Frog   864 AF---------------PSAGILTSSCQ---------YTMVPLRGVSTISNFP--------YANG 896

  Fly  1136 GGVGGSSRRSGSLSSSSASSSSNGSSKKQFHTNFVRHSNSNDGIYLLAEEEAAATLTPTSEREYA 1200
            ..|.|          :..|::.||:..:::.........:|.    |.||
Frog   897 SVVNG----------TCPSANPNGTKPREYDPETEHQDEANS----LLEE--------------- 932

  Fly  1201 AVCLTNGFKLPADVAKSGGGTY----NTTNNNNSSTNTSQKSATAKERQPRG--------NGNPI 1253
               :..|.|...:..|.||..:    ..|.:..|..:|.:    .||..|.|        .|:.:
Frog   933 ---MIPGHKDLTECPKPGGLCHPPGEGITVDRPSEIDTCE----IKELPPDGLQLEDENLVGHSL 990

  Fly  1254 SFSHNACKV 1262
            |.|:..|.:
Frog   991 SKSNKECPI 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plum	NP_001163744.1	IG_like	170..241	CDD:214653	19/72 (26%)
		IGc2	175..235	CDD:197706	18/61 (30%)
		IG_like	284..356	CDD:214653	21/90 (23%)
		I-set	360..443	CDD:254352	26/82 (32%)
		IGc2	378..435	CDD:197706	19/56 (34%)
		FN3	804..886	CDD:238020	11/81 (14%)
boc	NP_001072742.1	Ig strand D	359..363	CDD:409353	0/3 (0%)
		Ig strand E	365..369	CDD:409353	1/3 (33%)
		Ig strand F	378..386	CDD:409353	5/7 (71%)
		Ig strand G	389..397	CDD:409353	2/7 (29%)
		ISET-FN3_linker	401..454	CDD:406920	9/64 (14%)
		fn3	<474..539	CDD:394996	18/85 (21%)
		FN3	586..673	CDD:238020	19/117 (16%)
		FN3	702..789	CDD:238020	26/184 (14%)
		Ig strand A'	39..43	CDD:409353	0/3 (0%)
		IGc2	45..104	CDD:197706	14/85 (16%)
		Ig strand B	47..54	CDD:409353	2/6 (33%)
		Ig strand C	57..65	CDD:409353	3/28 (11%)
		Ig strand C'	67..70	CDD:409353	0/2 (0%)
		Ig strand E	80..86	CDD:409353	3/5 (60%)
		Ig strand F	93..101	CDD:409353	3/7 (43%)
		Ig strand G	104..114	CDD:409353	1/9 (11%)
		IG	128..203	CDD:214652	20/90 (22%)
		IGc2	236..297	CDD:197706	18/71 (25%)
		Ig strand B	239..243	CDD:409353	1/3 (33%)
		Ig strand C	252..256	CDD:409353	1/3 (33%)
		Ig strand F	287..292	CDD:409353	2/8 (25%)
		Ig strand G	300..303	CDD:409353	0/2 (0%)
		Ig strand A	313..316	CDD:409353	2/2 (100%)
		I-set	314..398	CDD:400151	26/83 (31%)
		Ig strand A'	322..325	CDD:409353	0/2 (0%)
		Ig strand B	331..338	CDD:409353	2/6 (33%)
		Ig strand C	344..349	CDD:409353	2/4 (50%)
		Ig strand C'	352..354	CDD:409353	0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10148
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000