DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plum and prtgb

DIOPT Version :9

Sequence 1:	NP_001163744.1	Gene:	plum / 43197	FlyBaseID:	FBgn0039431	Length:	1298	Species:	Drosophila melanogaster
Sequence 2:	XP_005174269.3	Gene:	prtgb / 572241	ZFINID:	ZDB-GENE-060302-1	Length:	1150	Species:	Danio rerio

Alignment Length:	1111	Identity:	225/1111 - (20%)
Similarity:	376/1111 - (33%)	Gaps:	347/1111 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 PIYCSWYRNDVVVEQVSYRKNDFFIYDNGTLRLP--TNEKASGEYYCKIEWDESAVISD--RITV 153
            |:...|.:|.|.:::....:    :..||:|.:.  |.::..|.|.|.......|:||.  |:|:
Zfish    58 PVSVRWRKNGVQIQESECVR----LLSNGSLCVSNLTQQRDEGYYQCIANNQYGAIISHRARLTI 118

  Fly   154 -------EYPVLKRLFPGQQQAANIS-ALENKPLVLSCPFLSVPAARFSWYFGNDSLTNDNSAL- 209
                   .:||...|..|  ..|..| |::..|:.:            ||.....||..|:..:
Zfish   119 TGVLVFSAHPVPLELRLG--SVARFSCAVDRSPVDI------------SWEINQRSLPQDSDRIT 169

  Fly   210 ILTNGTLILRHLRLEQAGKYKCVAQNTFASKTHRQFIWQLQVEPKDATFYPKNEAGITETAVSEA 274
            :|.||.|.:|::.:..||||:|||.|..:..|.|                             ||
Zfish   170 VLPNGVLQIRNVTMRDAGKYRCVAANAASRVTSR-----------------------------EA 205

  Fly   275 QLLPAFQNATVFVPAGG----------------------SVLLQCHAVADFVPIV-WYLQPPNNK 316
            :|        |.:||||                      .|:|:|.|..:..|:| |  ...::|
Zfish   206 EL--------VLIPAGGPRRLLKPLIIAGPQNISVALHQPVVLECLAEGNPRPLVSW--SRADSK 260

  Fly   317 MVRLSNNSVAYS---ITNASIARHEGRYSC--ITPLETQNF-----QVIVTTPPRIVSRLPVEVV 371
            .:.:|..||..:   :.:|..|.|.|.|.|  .|| .|:|:     .|.|..||.:|.:...:..
Zfish   261 PIDVSAASVLGNGNLMISAVKAHHSGTYVCRATTP-GTRNYTTAAGNVTVLLPPSLVEKPESQTR 324

  Fly   372 YIGLSRTLTCRAEGHPEPSITWYHNGVHLNSSYTRYISGNELHVHSFDSKEEGIYQCVARNVAGE 436
            ....:...:|:|||.|.|.|||:.||..:.::....:..|:|.:.....:::..|||:|.|..|.
Zfish   325 PRAGTARFSCQAEGTPTPQITWFKNGEVIRTNGRTKMYNNKLVITQIIPEDDAFYQCLAENSQGS 389

  Fly   437 DSATGELRFNRQLEEVNPLQNIRCYPHSFHSINITFDSRTL--------TSMFVVYIVR------ 487
            ..:|..|       .|...:|....|.:.|:..|:..:..|        ....:.|.:.
Zfish   390 VVSTSRL-------IVVQSENRPSAPRNIHAETISSSAILLAWERPQYNADKVIAYSIHYMKSEG 447

  Fly   488 -NN------------PHSWTSFSPMKLNQTSYVVISTDLPVYEPFALITRVLFPTTEVRTGTLVP 539
             ||            .|......|.: |.|.|:|....:........:||.......:||..|
Zfish   448 LNNEEYQAVIGNDTTSHIVDDLEPAR-NYTFYIVAYMAMGASRMSEQVTRHTLEDVPLRTPEL-- 509

  Fly   540 QQMILSSLRSTPVTCCTQGLMLRPIAVGNDTFVKW-------SQGQL------------------ 579
                  ||.|...|               |..|.|       |:|::
Zfish   510 ------SLTSRSPT---------------DILVSWQPLPPKLSRGRVSAYRLSYRTATDEQVNSV 553

  Fly   580 ------ENKKYFILQFSINHTHPHPAQLLNGSLQGTLTSVEEKADQVRHHL-------------T 625
                  ||...::||    ...|....|:..|: .|.....:.:....|..             .
Zfish   554 ELPVSGENGTQYLLQ----DLQPDTIYLIRMSV-STRVGWSQPSAWSSHRTPKTSSATVPPAPNL 613

  Fly   626 EIQPLNQS--------AAATVL----RNVEHEDNVVDDTLELEDDIFSL-VVDASVTGILLQRFT 677
            |::|||.:        ||:.||    :...|.|.      :.||.|..| ..|...|...|....
Zfish   614 ELEPLNCTSVSVRWFPAASDVLIQGFKLSFHPDG------QSEDSITQLPPQDHQHTITALNPRV 672

  Fly   678 RIKMRVLIITTENEFLGQDFRYVQWKIIENGTSEQS----NMPFRLVTRESRALAFKFLDSLNET 738
            :..::||..:.                  ||...|:    |.|....|...|..|....|
Zfish   673 KYHVKVLAFSA------------------NGDGYQAHQTVNTPGCPSTPNRRLAALPPPD----- 714

  Fly   739 CVLECHTEIQAQMS---------------------------LPSQDPKCQDRNIANSLLLVTGLK 776
                 ||..:|..|                           .||:....:....:...::||||:
Zfish   715 -----HTHAKANSSSAVHLSWGRPAFSSGKPVTFSVRYGPASPSEASSVRYIQTSEQTVMVTGLQ 774

  Fly   777 PDTRY----NLHFYNCKTRIFYGDIDEKT----EQDPPGTISNSKLIKQNGLKLMWEPPINPNGR 833
            |:|||    .||.....:. :...:.::|    ...||.::..: ||:.:...:.|:.|..||..
Zfish   775 PNTRYEFAVRLHMDQMSSP-WSATVYQRTLLEAPMSPPESVKVT-LIEADTALVCWKQPNQPNLS 837

  Fly   834 VHHYDIRWSLDNV----THEAIVKECTKCSYKFPNVSETAKIHVAVRVMGDTGAGAPMYFDMI-- 892
            |.||.:.::..:.    ..:.:.:|.|........: |:..::: |::.....||...:.:.:
Zfish   838 VTHYTVLYASQSSWLAGEWQVLQREGTNTMALLEKL-ESGNVYL-VKISASNLAGDGPFSNTVEL 900

  Fly   893 ---NNNHTWLKEESESSHSE-------VY-------SGIAIGSLLSIACVFLFGLFIIFQQRNFK 940
               ...|.........||:|       :|       |||.:|..::::|:.|. :||:..:...:
Zfish   901 AVKGKPHHGKNPRHADSHAEKTAFIDGLYHIDEKSMSGIIVGVCIALSCIILC-IFILLSKTQTQ 964

  Fly   941 ARAQGPTHLTTPTDINFGNLSSASGMPGDSAGGLSGGTLQQDCHEMQTLIPRSRYHI-------E 998
            ..|......:...::.....|||:..|.::|               :.|:|..|.|.       .
Zfish   965 KSASSKMIGSMRNEVMHNEASSANQQPAENA---------------EVLLPMMRNHFIDAKGGSN 1014

  Fly   999 LLPEHS 1004
            ||..|:
Zfish  1015 LLINHA 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plum	NP_001163744.1	IG_like	170..241	CDD:214653	21/72 (29%)
		IGc2	175..235	CDD:197706	18/60 (30%)
		IG_like	284..356	CDD:214653	27/104 (26%)
		I-set	360..443	CDD:254352	22/82 (27%)
		IGc2	378..435	CDD:197706	18/56 (32%)
		FN3	804..886	CDD:238020	17/85 (20%)
prtgb	XP_005174269.3	Ig	31..118	CDD:325142	15/63 (24%)
		I-set	123..207	CDD:333254	30/126 (24%)
		Ig_3	220..293	CDD:316449	17/74 (23%)
		I-set	313..398	CDD:254352	23/91 (25%)
		FN3	405..498	CDD:238020	15/93 (16%)
		FN3	509..599	CDD:238020	19/117 (16%)
		FN3	608..687	CDD:238020	21/102 (21%)
		FN3	711..802	CDD:238020	17/101 (17%)
		FN3	809..899	CDD:238020	17/92 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900