DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plum and fndc1

DIOPT Version :9

Sequence 1:	NP_001163744.1	Gene:	plum / 43197	FlyBaseID:	FBgn0039431	Length:	1298	Species:	Drosophila melanogaster
Sequence 2:	XP_003200760.2	Gene:	fndc1 / 557836	ZFINID:	ZDB-GENE-041210-332	Length:	1645	Species:	Danio rerio

Alignment Length:	903	Identity:	169/903 - (18%)
Similarity:	286/903 - (31%)	Gaps:	322/903 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   559 LMLRPIAVGNDTFVKWSQGQLENKKYFILQFSINHTHPHPAQLLNGSLQGTLTSVEEKADQVRHH 623
            |.:||:   |...|..||.|.:.:         |...|   :|.:.|:.  :.|::....|.|.
Zfish   181 LPIRPL---NKHRVDLSQHQADQR---------NANKP---KLASESVY--VVSLQAPRAQGRS- 227

  Fly   624 LTEIQPLNQSAAATVLRNVEHEDNVVDDTLELEDDIFSLVVDASVTGILLQRFTRIKMRVL---- 684
                .|:|   .||:.:.|..|..|||   |:||                     |.:|||
Zfish   228 ----APIN---TATMSKKVITESEVVD---EVED---------------------ITVRVLSPQS 261

  Fly   685 -IIT------TENEFLGQDFRYVQWKIIENGTSEQSNMPFRLVTRESRALAFKFLDSLNETCVLE 742
             :||      .:|:.:....||.:.|..|.|.|.:                :::.|:....
Zfish   262 VLITWVDPPVEKNKEIPGGSRYYRVKYREKGESAR----------------WEYKDTTQRR---- 306

  Fly   743 CHTEIQAQMSLPSQDPKCQDRNIANSLLLVTGLKPDTRYNL--------HFYNCKTRIFYGDIDE 799
                                       |::..|..|:.|..        |.......:|     :
Zfish   307 ---------------------------LMIETLSADSMYEFSICISQGNHMGKWSASVF-----Q 339

  Fly   800 KT-EQDPPGTISNSKLI----KQNGLKLMWEPPINPNGRVHHYDIRWS-------LDNVTHEAIV 852
            :| |..|.|...|.::.    |...:...|:||...|||:..|.:.::       ..:||:..
Zfish   340 RTPESAPSGPPENFEVKPLRGKGTAVTATWDPPEQTNGRLREYILSYAPAMKPFGAKSVTYRG-- 402

  Fly   853 KECTKCSYKFPNVSETAKIHVAVRVMGDTGAGAPMYFDMI------NNNHTWLKEESESSHS--- 908
               |..|.....::...:....:|.:...|.| |....:|      :|.||...:...:|.|
Zfish   403 ---TTTSATIDGLTPGDRYIFKIRAVNRKGQG-PQTKAIIVSMPASSNTHTRNMDSQRTSQSTSK 463

  Fly   909 ------------------------------------------EVYSGIAIGSLLSIACVFLFGLF 931
                                                      .::|.:. ||:
Zfish   464 TSSNNESDYQEPDEMEEPNTQTTTQAPNTNRRRPLSQTRSYHSIFSSVR-GSV------------ 515

  Fly   932 IIFQQRNFKARAQGPTHLTTPTDINFGNLSSASGMPGDSAGGLSGGTLQQDCHEMQTLIPRSRYH 996
                 ||..:::...|..|...|.......:|.. |.:...|.:..|...:........|:::.|
Zfish   516 -----RNGGSKSNLHTSSTHTKDREDEEKPTADS-PIEEKTGANEATEDTNPERSNNASPQTQEH 574

  Fly   997 IELLPEHSLEYQTSTAAV-----------------AVVHL------ANGNGSVQVARRSDQDGAA 1038
            .:|.|: :.|.:.|.:.:                 ::|.:      ::.:||....|..|...::
Zfish   575 SKLSPD-TKESKPSNSDIVPKTSEDKRPPWTPRTSSIVDISRLRRPSSRSGSRSRMRSEDTSSSS 638

  Fly  1039 QGDLGIAGVHNLSQLPLCGVGGTSPERKTVQDAM-----LQEAKAFYIPYRHTPPNAVALSSSKQ 1098
            ......|...:|:.:.... |..|..:.||.|:|     .||.:.  .|.:.:.|::...||...
Zfish   639 LNQESAATRKDLTAVSYPD-GQKSHNQITVTDSMPSVASPQENRP--EPVKESEPSSSISSSPTY 700

  Fly  1099 CAVPSGSELEVIVPPNSLPLVTTMPGLGVVGGGGSG-----GGGVGGSSR----RSGSL---SSS 1151
            .:..|.|...|..|.:|||   :..|......|.||     |..||.|:|    ::|..   |||
Zfish   701 SSSASSSSSSVSSPSSSLP---SSSGTRRFSSGASGAKYPNGRRVGISTRGQRLQTGKPKPDSSS 762

  Fly  1152 SASSSS---NGSSKKQFHTNFVRHSN---------------SNDGIYLLAEEEAAATLTPTSERE 1198
            ||||.|   .|:|.....|..|..:|               .||.    .||:...:.:.:|.|.
Zfish   763 SASSQSTLPTGTSTDNHDTTEVHDTNQKITKLNTEELPVPKENDD----NEEKTVDSTSHSSSRT 823

  Fly  1199 YAAVC-LTNGFKLP--------------------ADVAKSGGGT-----YNTTNNNNSSTNTSQK 1237
            ..:.. .::.|.||                    ...:..|.|.     :.:.:.:.||.:||.|
Zfish   824 NPSTTGRSSSFSLPNRNSRIVTSSRRQDGRIPWSRSASSVGAGRPIIKGFPSRSTSVSSQDTSDK 888

  Fly  1238 SATAKERQPRGNGNPISFSHNACKVPANGPASVNVNHSS---------AVKQSWPAAT 1286
            :..:....|:...||:|          |.|:.:||..|:         ..|:.|...|
Zfish   889 NKVSPTVYPKHKVNPVS----------NKPSLLNVKSSNDHEDDYLYEGSKEIWDRQT 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plum	NP_001163744.1	IG_like	170..241	CDD:214653
		IGc2	175..235	CDD:197706
		IG_like	284..356	CDD:214653
		I-set	360..443	CDD:254352
		IGc2	378..435	CDD:197706
		FN3	804..886	CDD:238020	18/92 (20%)
fndc1	XP_003200760.2	FN3	28..108	CDD:214495
		FN3	247..341	CDD:238020	24/169 (14%)
		FN3	348..439	CDD:238020	18/96 (19%)
		FN3	1408..1500	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900