DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment plum and igdcc3

DIOPT Version :9

Sequence 1:	NP_001163744.1	Gene:	plum / 43197	FlyBaseID:	FBgn0039431	Length:	1298	Species:	Drosophila melanogaster
Sequence 2:	XP_003199017.2	Gene:	igdcc3 / 555947	ZFINID:	ZDB-GENE-080303-24	Length:	773	Species:	Danio rerio

Alignment Length:	737	Identity:	156/737 - (21%)
Similarity:	257/737 - (34%)	Gaps:	203/737 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ILLLLLT--DHNGRLTLTKESTTVAAAVAQPKNSTALQPYLQIQKHAVTRLTISKPHSPYYLPCI 79
            ||||...  .....|:.|.|.:.:.|...||     |..:.|::.                   |
Zfish    15 ILLLAFVGLTCGAELSFTLEPSDIIAVQQQP-----LMLHCQVEG-------------------I 55

  Fly    80 PILTPYNHDQDNQPIYCSWYRNDVVVEQVSYRKNDFFIYDNGTLRLPTNEKA-------SGEYYC 137
            |            ||...|.|:..:|::    .:::.::.||:|.:...:|.       .|:|.|
Zfish    56 P------------PISTQWRRSGALVQE----DHNYVMFTNGSLLITHFQKIKTDGSSDEGDYEC 104

  Fly   138 KIEWDESAVISDRITVEYPVLKRLFPGQQQAANISALENKPLVL----------SCPFLSVPAAR 192
            ..:.....|:|.:..|             |||.::....:|..:          .|....:|...
Zfish   105 IAQNFFGLVVSRKARV-------------QAATMADFHVQPESVRADVGGVGRFQCQIHGLPEPV 156

  Fly   193 FSW-YFGNDSLTNDNSALILTNGTLILRHLRLEQAGKYKCVAQNTFASKTHRQFIWQLQVEPKDA 256
            .|| ..|....|:|....:|..|.|.:..:|.|.:|.|.|||.|: |...|.... ||.|....:
Zfish   157 ISWERDGRPVDTSDERFTLLPTGVLQITGVRPEDSGVYCCVAHNS-AGVKHSAGA-QLTVSGSQS 219

  Fly   257 TFYPKNEAGITETAVSEAQLLPAFQNATVFVPAGGSVLLQCHAVADFVPIV-WYLQPPNNKMVRL 320
            :.|            .|..:|...:|.|:.|..  :.:|:|.|.....||| |         .||
Zfish   220 SVY------------KEPMILVGPENLTLTVHQ--TAILECVATGYPRPIVSW---------SRL 261

  Fly   321 SNNSVAYS-----------ITNASIARHEGRYSCITPLETQNFQVIVTTPPRIVSRLPVEVVY-- 372
            ....:...           |::..: :|.|.|.|..  .....:|..|....:|.:.|.|.|.
Zfish   262 DGRPIGVEGIQVLGTGNLMISDVRV-QHSGVYVCAA--NKPGTRVRRTAQGLLVVQAPAEFVQPP 323

  Fly   373 ------IGLSRTLTCRAEGHPEPSITWYHNGVHLN-SSYTRYISGNE-LHVHSFDSKEEGIYQCV 429
                  :|.:...||.|:|.|.|.|||..||..|. ..:.:..:.|. |.::....::|.||||:
Zfish   324 QSIARPVGTTAIFTCLAQGEPVPQITWLKNGQILEPDGHVKLRNNNSTLTIYGVTQEDEAIYQCI 388

  Fly   430 ARNVAGEDSATGELRF-----------NRQLEEVNPLQNIRCYPHSFHSINITFDSRTLTSMFVV 483
            |.|.||...|:..|..           :.|.:.::|.           ||.:|:...|..:..::
Zfish   389 AENSAGSTQASARLTVLWADGLPGMPTDIQADALSPT-----------SIQVTWKEPTQNTQDII 442

  Fly   484 -YIVRNNPHSWTSFSPMKLNQTSYVVIST------DLPVYEPFALITRVLFPTTEVRTGTLVPQQ 541
             |::    |...:..|:::.....|...|      ||   ||....:..:...|. |..:...:.
Zfish   443 GYVL----HIRKTADPVEMEYQEAVSKMTLQQVIGDL---EPSTSYSFYVKAYTS-RGASKASET 499

  Fly   542 MILSSLRSTPV--TCCTQGLMLRPIAVGNDTFVKWSQGQ---LENKKYFILQFSINHTHPHPAQL 601
            .:.|:|...|.  ...|:.:.|..|....:...|..|.:   |..:|..:.||:...|.|.
Zfish   500 TVESTLGEVPAPPALFTKVINLTVIQATWEASTKMGQQEGFNLYYRKVPVPQFTGPLTFPR---- 560

  Fly   602 LNGSLQGTLTSVEEKADQVRHHLTEIQP----------LNQSAAA-TVLRNVEHEDNVVDDTLEL 655
                            |.:::::|::.|          .||.... ..||.|..::.|....|..
Zfish   561 ----------------DVMQYNITQLDPSFVYEIKILAFNQHGEGNATLRFVSLKEAVEKSVLNT 609

  Fly   656 EDDIFSLVVD----ASVTGILL 673
            ..|   .|.|    :|.|||::
Zfish   610 PCD---CVKDEQNKSSTTGIII 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plum	NP_001163744.1	IG_like	170..241	CDD:214653	20/81 (25%)
		IGc2	175..235	CDD:197706	18/70 (26%)
		IG_like	284..356	CDD:214653	17/83 (20%)
		I-set	360..443	CDD:254352	29/92 (32%)
		IGc2	378..435	CDD:197706	21/58 (36%)
		FN3	804..886	CDD:238020
igdcc3	XP_003199017.2	Ig1_Neogenin	30..122	CDD:143199	24/144 (17%)
		I-set	128..214	CDD:254352	23/87 (26%)
		Ig	130..214	CDD:299845	23/85 (27%)
		Ig	229..307	CDD:299845	18/91 (20%)
		IG_like	231..313	CDD:214653	19/95 (20%)
		I-set	318..404	CDD:254352	28/85 (33%)
		IGc2	331..394	CDD:197706	22/62 (35%)
		FN3	411..504	CDD:238020	17/111 (15%)
		fn3	509..589	CDD:278470	17/99 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900