DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plum and Nphs1

DIOPT Version :9

Sequence 1:	NP_001163744.1	Gene:	plum / 43197	FlyBaseID:	FBgn0039431	Length:	1298	Species:	Drosophila melanogaster
Sequence 2:	NP_062332.2	Gene:	Nphs1 / 54631	MGIID:	1859637	Length:	1256	Species:	Mus musculus

Alignment Length:	803	Identity:	165/803 - (20%)
Similarity:	254/803 - (31%)	Gaps:	277/803 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 RITVEYPVLKRLFPGQQQAANISALENKPLVLSCPFLSVPAAR-FSWYFGNDSLTNDNSALILTN 213
            |:.|.||   ..|.|:|..| ::.:|....:|.....:.||.. |:|.|
Mouse   653 RLNVLYP---PEFLGEQVRA-VTVVEQGQALLPVSVSANPAPEAFNWTF---------------- 697

  Fly   214 GTLILRHLRLEQAGKYKCVAQNTFASKTHRQF------IWQLQVEPKDATFYP---KNEAGITET 269
                 |..||..||           ...||..      :|  .|...|..||.   :|..|..|.
Mouse   698 -----RGYRLSPAG-----------GPRHRILSGGALQLW--NVTRADDGFYQLHCQNSEGTAEA 744

  Fly   270 A----VSEAQLLPAFQNATVFVPAGGSVLLQCHAVADFVPIV-----WYLQPPNNK------MVR 319
            .    |..|..:.|.::.|. |..||||.:.|  ..|..||:     |.....:.:      |.:
Mouse   745 LLKLDVHYAPTIRALKDPTE-VNVGGSVDIVC--TVDANPILPEMFSWERLGEDEEELNLDDMEK 806

  Fly   320 LSNNSVA-YSITNASIARHEGRYSCI-----TPLETQNFQVIVTTPPRIVSRLPV-EVVYIG--- 374
            :|..|.. ..|..|.::: .|.|.||     .|......:::|...|::....|: :|...|
Mouse   807 MSKGSTGRLRIRQAKLSQ-AGAYQCIVDNGVAPAARGLVRLVVRFAPQVDHPTPLTKVAAAGDST 870

  Fly   375 LSRTLTCRAEGHPEPSITWYHNGVHLNSSYTRYISGNELH---VHS--------FDSKEEGIYQC 428
            .|.||.|||.|.|....||..|||.|:....|| :.::.|   |||        ..:::..:::|
Mouse   871 SSATLHCRARGVPNIDFTWTKNGVPLDLQDPRY-TEHKYHQGVVHSSLLTIANVSAAQDYALFKC 934

  Fly   429 VARNVAGEDSATGELRFNRQLEEV---NPLQNIRCYPHSFHSINIT----FDSRTLTSMFVVYIV 486
            .|.|..|.|..      |.||..:   :|...::....|.||:.:.    ||........:.|..
Mouse   935 TATNALGSDHT------NIQLVSISRPDPPLGLKVVSVSPHSVGLEWKPGFDGGLPQRFQIRYEA 993

  Fly   487 RNNPHSWTSFSPMKLNQTSYVVISTDLPVYEPFALITRVLFPTTEVRTGTLVPQQMILSSL--RS 549
            ..:|    .|..|.:           ||.......:|. |.|:|..|...|....:..|.|  :.
Mouse   994 LESP----GFLYMDV-----------LPAQATTFTLTG-LKPSTRYRIWLLASNALGDSGLTDKG 1042

  Fly   550 TPVTCCTQGLMLRPIAVGNDTFVKWSQGQLENKKYFILQFSINHTHPHPAQLLNGSLQGTLTSVE 614
            ..|:..|.||...|    .||                       ..|.|.:...|..:..|..|
Mouse  1043 IQVSITTPGLDQAP----EDT-----------------------DQPLPTEQPPGPPRLPLLPV- 1079

  Fly   615 EKADQVRHHLTEIQPLNQSAAATVLRNVEHEDNVVDDTLELEDDIFS-----LVVDASVTGILL- 673
                                                        :|:     |:.:||..|.||
Mouse  1080 --------------------------------------------LFAVGGLLLLSNASCVGGLLW 1100

  Fly   674 -QRFTRIKMRVLIIT---TENEFLGQDFRYVQWKIIENGTSEQSNMPFRLVTRESRALAFKFLDS 734
             :|..|:...:...|   :|.:.:..::...||      |.:          |::|:       |
Mouse  1101 RRRLRRLAEEISEKTEAGSEEDRIRNEYEESQW------TGD----------RDTRS-------S 1142

  Fly   735 LNETCVLECHTEIQAQMSLPSQDPKCQDRNIANSLLLVTGLK-PDTRYNLHFYNCKTRIFYGDID 798
            ...|..::.|.......| |...|..::.:...:.   ||:: .|..:..|.|:...|: ||
Mouse  1143 TVSTAEVDPHYYSMRDFS-PQLPPTLEEVSYRQAF---TGIEDEDMAFPGHLYDEVERV-YG--- 1199

  Fly   799 EKTEQDPPGTISNSKLIKQNGLKLMWEPPINPNGRVHHYDIRWSLDNVTHEAIVKECTKCSYKFP 863
                  |||               :| .|:....::..||:||                     |
Mouse  1200 ------PPG---------------VW-GPLYDEVQMDPYDLRW---------------------P 1221

  Fly   864 NVSETAKIHVAVRVMGDTGAGAP 886
            .|.......:..:|..|..||.|
Mouse  1222 EVKYEDPRGIYDQVAADMDAGEP 1244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plum	NP_001163744.1	IG_like	170..241	CDD:214653	12/71 (17%)
		IGc2	175..235	CDD:197706	12/60 (20%)
		IG_like	284..356	CDD:214653	21/88 (24%)
		I-set	360..443	CDD:254352	29/97 (30%)
		IGc2	378..435	CDD:197706	22/67 (33%)
		FN3	804..886	CDD:238020	15/81 (19%)
Nphs1	NP_062332.2	Ig	52..128	CDD:299845
		IG_like	52..127	CDD:214653
		C2-set_2	155..242	CDD:285423
		Ig	254..332	CDD:299845
		IG_like	268..350	CDD:214653
		C2-set_2	358..440	CDD:285423
		Ig	459..544	CDD:299845
		I-set	460..555	CDD:254352
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..516
		Ig	563..646	CDD:299845
		IG_like	670..750	CDD:214653	22/113 (19%)
		Ig	676..750	CDD:299845	21/107 (20%)
		Ig_3	753..834	CDD:290638	22/84 (26%)
		IG_like	762..848	CDD:214653	21/89 (24%)
		Ig	848..956	CDD:299845	33/114 (29%)
		IG_like	859..949	CDD:214653	29/96 (30%)
		fn3	956..1039	CDD:278470	19/98 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1048..1071		8/49 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1112..1143		7/53 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11640
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100