DRSC/TRiP Functional Genomics Resources

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Protein Alignment plum and NEO1

DIOPT Version :10

Sequence 1:NP_651482.3 Gene:plum / 43197 FlyBaseID:FBgn0039431 Length:1298 Species:Drosophila melanogaster
Sequence 2:NP_001406460.1 Gene:NEO1 / 4756 HGNCID:7754 Length:1481 Species:Homo sapiens


Alignment Length:1331 Identity:265/1331 - (19%)
Similarity:432/1331 - (32%) Gaps:407/1331 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   173 ALENKPLVLSCPFLSVPAARFSW----YFGNDSLTNDNSALILTNGTLIL------RHLRLEQAG 227
            ::....::|:|...|.|:.:..|    .|.|  |.:|:...:|.:|:|.:      :|.:.:: |
Human    64 SVRGSSVILNCSAYSEPSPKIEWKKDGTFLN--LVSDDRRQLLPDGSLFISNVVHSKHNKPDE-G 125

  Fly   228 KYKCVAQ----NTFASKTHRQFIWQLQVEPKDATFYPKNEAGITETAVSEAQLLPAF--QNATVF 286
            .|:|||.    .|..|:|.:..:                 ||           ||.|  |.....
Human   126 YYQCVATVESLGTIISRTAKLIV-----------------AG-----------LPRFTSQPEPSS 162

  Fly   287 VPAGGSVLLQCHAVADFVPIVWYLQ--PP---NNKMVRLSNNSVAYSITNASIARHEGRYSCIT- 345
            |.||.:.:|.|...||.||.|.:.|  .|   ::::::|.:..:.  |:||: ....|.|.|:. 
Human   163 VYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLV--ISNAT-EGDGGLYRCVVE 224

  Fly   346 ----PLETQNFQVIVTTPPRIVSRL-----PVEVV-YIGLSRTLTCRAEGHPEPSITWYHNGVHL 400
                |..:...::.|...|.::|.|     |..:| .||....|.|.|.|.|.|:|.|..|...|
Human   225 SGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEAL 289

  Fly   401 NSSYTR---YISGNELHVHSFDSKEEGIYQCVARNVAGEDSATGELRFNRQLEEVNPLQNIRCYP 462
            ::..:.   .::|..|.:......:.|.|.|:|.|......|..||....|.|.:....||  |.
Human   290 DTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNI--YA 352

  Fly   463 HSFHSINITFDSR-----TLTSMFVV---------YIVRNNPHSWTSFSPMKLNQTSY------- 506
            |  .|::|.|:..     |.|..:|.         |......|:......:|.::..|       
Human   353 H--ESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAEND 415

  Fly   507 ----------VVISTD--LPVYEPFAL---ITRVLFPTTEVRTGTL--VPQQMILSSLRSTPVTC 554
                      :::..|  :|...|.:|   .|..|.|.|   ||.|  .|:. :::||.||    
Human   416 VGNAQAGAQLIILEHDVAIPTLPPTSLTSATTDHLAPAT---TGPLPSAPRD-VVASLVST---- 472

  Fly   555 CTQGLMLRPIAVGNDTFVK--W----SQGQLENKKY--FILQFSI------NHTHPHPAQLLNGS 605
                           .|:|  |    |....:|..|  |..:..|      |.:||...|:...:
Human   473 ---------------RFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQN 522

  Fly   606 LQGTLTSVEEKADQVRHH--------LTEIQP----------LNQSAAATVLRNVEHEDNV---- 648
            |......:.....|.:|.        ..|.||          |...||:.....|..|..|    
Human   523 LMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNG 587

  Fly   649 ---------VDDTLELEDDIFSLVVDASVTGILLQRFTRIKMRVLI-------ITTEN------- 690
                     ::...:.|.|:.......::.|  |:::|....||:.       ::|.:       
Human   588 EIQNYKLYYMEKGTDKEQDVDVSSHSYTING--LKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLS 650

  Fly   691 -------EFLGQDFR-----YVQWK----IIENGTSEQSNMPFRLVTRESRALAFKFLDSLNETC 739
                   :.|..:.|     .:.|:    ..:||......:.:|..:|:|         .:.||.
Human   651 DVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKS---------DVTETL 706

  Fly   740 VLECHTEIQAQMSLPSQDPKCQDRNIANSLLLVTGLKPDTRYNLHFYNCKTRIFYGDIDEKTEQD 804
            |    :..|....:...| :..:.|...:.|.:.|..|.|.:      .....|..|:||....:
Human   707 V----SGTQLSQLIEGLD-RGTEYNFRVAALTINGTGPATDW------LSAETFESDLDETRVPE 760

  Fly   805 PPGTISNSKLIKQNGLKLMWEPPINPNGRVHHYDIRWSLDNVTHEAIVKECTKCSYKFPNVSETA 869
            .|.::....|:  ..:.:.|.||.|.|..|..|.|.:.:.:...:.|..:..:..|...|:..::
Human   761 VPSSLHVRPLV--TSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSS 823

  Fly   870 KIHVAVRVMGDTGAGAPMYFDMINNNHTWLKE--------------------------ESESSHS 908
            ...:.::...:.|.|.|:|...:...||...|                          .|..||.
Human   824 HYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHD 888

  Fly   909 EVYSGIAIGSLLSIACVFLFGLFIIFQQRNFKARAQGPTHLTTPTDINFGNLSSASGMPGDSAGG 973
            .:....|..||....        .|...|.:..|.:  |::...|.....|.::.|.:    ..|
Human   889 TIRITWADNSLPKHQ--------KITDSRYYTVRWK--TNIPANTKYKNANATTLSYL----VTG 939

  Fly   974 LSGGTLQQDCHEMQTLIPRSRYH-----------IELLPEHSLEYQTSTAAVAVVHLANGNGSVQ 1027
            |...||    :|...::.:.|..           .||:|       ||......|....|.....
Human   940 LKPNTL----YEFSVMVTKGRRSSTWSMTAHGTTFELVP-------TSPPKDVTVVSKEGKPKTI 993

  Fly  1028 VAR---RSDQDGAAQG-------DLGIAGVHNLSQLPLCGVGGTSPERKT--VQDAMLQEAKAFY 1080
            :..   .|:.:|...|       |:. |.:|:....|:.|      .|.|  :|:..|.....|.
Human   994 IVNWQPPSEANGKITGYIIYYSTDVN-AEIHDWVIEPVVG------NRLTHQIQELTLDTPYYFK 1051

  Fly  1081 IPYRHTPPNAVALSSSKQCAVPSGSELEVIVPPNSLPLVTTMPGLGVVGGGGSGGGGVGGSSRRS 1145
            |..|:: .....:|.:.|...|.....:            .||.....|.||.|.        |.
Human  1052 IQARNS-KGMGPMSEAVQFRTPKADSSD------------KMPNDQASGSGGKGS--------RL 1095

  Fly  1146 GSLSSS-----SASSSSNGSSKKQFHTNFVRHSNSNDGIYLLAEEEAAATLTPTSEREYAAVCLT 1205
            ..|.|.     |.|:|.:||......:|.           ||....:...:|.......|..|  
Human  1096 PDLGSDYKPPMSGSNSPHGSPTSPLDSNM-----------LLVIIVSVGVITIVVVVIIAVFC-- 1147

  Fly  1206 NGFKLPADVAKSGGGTYNTTNNNNSSTNTSQKSATAKERQPRGNGNPISFSHNACKVPANGPASV 1270
                           |..||::        ||...|                 |||       ||
Human  1148 ---------------TRRTTSH--------QKKKRA-----------------ACK-------SV 1165

  Fly  1271 NVNH-----SSAVKQSWPAATVVHRRAQVDP 1296
            |.:|     |..||.  |...:.|.|.::.|
Human  1166 NGSHKYKGNSKDVKP--PDLWIHHERLELKP 1194

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
plumNP_651482.3 Ig 179..245 CDD:409353 21/79 (27%)
Ig strand B 179..183 CDD:409353 1/3 (33%)
Ig strand C 192..196 CDD:409353 1/7 (14%)
Ig strand E 214..218 CDD:409353 2/3 (67%)
Ig strand F 228..233 CDD:409353 2/4 (50%)
Ig strand G 242..245 CDD:409353 0/2 (0%)
IG_like 284..356 CDD:214653 20/81 (25%)
Ig 360..443 CDD:472250 25/91 (27%)
Ig strand B 377..381 CDD:409353 1/3 (33%)
Ig strand C 390..394 CDD:409353 1/3 (33%)
Ig strand E 411..415 CDD:409353 1/3 (33%)
Ig strand F 425..430 CDD:409353 2/4 (50%)
Ig strand G 438..441 CDD:409353 1/2 (50%)
FN3 804..886 CDD:238020 15/81 (19%)
NEO1NP_001406460.1 IgI_1_Neogenin_like 52..148 CDD:409387 21/86 (24%)
Ig strand A 52..55 CDD:409387
Ig strand A' 58..64 CDD:409387 265/1331 (20%)
Ig strand B 68..78 CDD:409387 2/9 (22%)
Ig strand C 82..88 CDD:409387 1/5 (20%)
Ig strand C' 90..93 CDD:409387 0/2 (0%)
Ig strand D 100..105 CDD:409387 0/4 (0%)
Ig strand E 107..113 CDD:409387 2/5 (40%)
Ig strand F 125..132 CDD:409387 4/6 (67%)
Ig strand G 137..148 CDD:409387 3/10 (30%)
IG_like 158..239 CDD:214653 20/83 (24%)
Ig strand B 169..173 CDD:409353 1/3 (33%)
Ig strand C 182..186 CDD:409353 1/3 (33%)
Ig strand E 204..208 CDD:409353 0/5 (0%)
Ig strand F 218..223 CDD:409353 2/4 (50%)
I-set 250..337 CDD:400151 24/86 (28%)
Ig strand B 266..270 CDD:409353 1/3 (33%)
Ig strand C 279..283 CDD:409353 1/3 (33%)
Ig strand E 303..307 CDD:409353 1/3 (33%)
Ig strand F 317..322 CDD:409353 2/4 (50%)
Ig strand G 330..333 CDD:409353 1/2 (50%)
IgI_4_Neogenin_like 344..427 CDD:409388 14/86 (16%)
Ig strand A 344..347 CDD:409388 0/2 (0%)
Ig strand A' 349..353 CDD:409388 3/5 (60%)
Ig strand B 356..365 CDD:409388 2/8 (25%)
Ig strand C 370..376 CDD:409388 1/5 (20%)
Ig strand C' 378..381 CDD:409388 0/2 (0%)
Ig strand D 386..390 CDD:409388 1/3 (33%)
Ig strand E 394..398 CDD:409388 0/3 (0%)
Ig strand F 406..414 CDD:409388 1/7 (14%)
Ig strand G 417..427 CDD:409388 0/9 (0%)
FN3 459..552 CDD:238020 20/112 (18%)
FN3 <522..944 CDD:442628 77/459 (17%)
FN3 976..1071 CDD:238020 20/102 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1061..1117 17/75 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1158..1180 10/45 (22%)
Neogenin_C 1178..1481 CDD:461954 6/19 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1194..1226 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1255..1296
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1309..1401
Blue background indicates that the domain is not in the aligned region.

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