DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plum and Fndc1

DIOPT Version :9

Sequence 1:	NP_001163744.1	Gene:	plum / 43197	FlyBaseID:	FBgn0039431	Length:	1298	Species:	Drosophila melanogaster
Sequence 2:	XP_006227933.1	Gene:	Fndc1 / 308099	RGDID:	1310640	Length:	1831	Species:	Rattus norvegicus

Alignment Length:	1421	Identity:	245/1421 - (17%)
Similarity:	401/1421 - (28%)	Gaps:	561/1421 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 PKNST-------------ALQPYLQIQKHAVTRLTISKPHSP---YYLPCIPILTPYNHDQDNQP 93
            ||::|             :|:....|:.:|.|...:.|...|   |::    ::|..||...::|
  Rat    59 PKDATSRPVEHYNIAYGKSLKSLKSIKVNAETHSFLIKDVEPGVVYFV----LVTAENHSGVSRP 119

  Fly    94 IYCS-------WYR------------NDVVVEQVSYRKNDFFIYDNGTLRLPTNEKASGEYYCKI 139
            :|.:       |.:            |:.:.|:.         ..|..||:  ..:||
  Rat   120 VYRAESPPGGEWIKIDGFPNKGPGPFNETITEKE---------VPNKPLRM--RVRAS------- 166

  Fly   140 EWDESAVISDRITVEYPVLKRLFPGQQQAANISALENKPLVLSCPFLSVPAARFSWYFGNDSLTN 204
                    .||::|.:           :|..:|..::            |.....:..|......
  Rat   167 --------DDRLSVAW-----------KAPRLSGAKS------------PRRSRGFLLGYGESGR 200

  Fly   205 DNSALILTNGTLILRHLRLEQAGKYKCVAQNTFASKTHRQFIWQLQVEPKDATFYPKNEAGITET 269
            ..:.:.||         |.|::.:.|.:|..:.       ::..||.........|...|.:|:.
  Rat   201 KMNYVPLT---------RDERSHEIKKLASESV-------YVVSLQSTNSQGQSQPVYRAALTKR 249

  Fly   270 AVSEAQLLPAFQNATVFVPAGGSVLLQCHAVADFVPIVWYLQPPNNKMVRLSNNSVAYSITNASI 334
            ..:|...|...::.:|.|.:..|||           :.|
  Rat   250 KNAEEDELDVPEDISVRVMSSQSVL-----------VAW-------------------------- 277

  Fly   335 ARHEGRYSCITPLETQNFQVIVTTPPRIVSRLPVEVVYIGLSRTLTCRAEGHPEPSITWYHNGVH 399
                     :.||        |....|:|:           ||..|.|.....| |..|.:
  Rat   278 ---------VDPL--------VEKQKRVVA-----------SRQYTVRYREKGE-SARWDY---- 309

  Fly   400 LNSSYTRYISGNELHVHSFDSKEEGIYQCVARNVAGEDSATGELRFNRQLEEVNPL---QNIRCY 461
                  :.:|.....|.|.  ..:.:|:...|...||..........::..|..|.   :|:|.:
  Rat   310 ------KQVSNRRALVDSL--IPDTVYEFAVRISQGERDGKWSASVFQRTPESAPTTAPENLRVW 366

  Fly   462 PHSFHSINITFDSRTLTSMFVVYIVRNNPHSWTSFSPMKLNQTSYVVISTDLPVYEPFALITRVL 526
            |.:.....:|.                   ||.:....:.....|::  :..|..:||. ...:.
  Rat   367 PVNGKPTVVTV-------------------SWDALPESEGKVKEYIL--SYAPALKPFG-AKSLT 409

  Fly   527 FP--TTEVRTGTLVPQQMILSSLRSTPVTCCTQGLMLRPIAVGNDTFVKWSQGQLENKKYFILQF 589
            |.  ||......|.|.:..|..:|:|.                       .:||..:.|.||:
  Rat   410 FSGHTTSALVDGLQPGERYLFKIRATN-----------------------RRGQGPHSKAFIV-- 449

  Fly   590 SINHTHPHPAQLL-NGSLQGTLTSVEEKADQVRHHLTEIQPLNQSAAATVLRNVEH---EDNVVD 650
            :|..|....|.:. ||...|.    .||..|           ..|:|..|..:.:|   ..||.|
  Rat   450 AIPTTSSTEASVQPNGRDNGK----PEKPQQ-----------PSSSAPKVAASSQHMPPAKNVKD 499

  Fly   651 DTLELEDDIFSLVVDASVTGILLQRFTRIKMRVLIITTEN-EFLGQDFRYVQWKIIENGTSEQ-- 712
            ...:|::.|       ...|:...| |::..:|..:..:: |..|::    :...:||..|.:
  Rat   500 ALSDLKNKI-------QTNGVAPGR-TQLHSKVGELDPQSTEVTGEE----ELDSLENPRSSRLE 552

  Fly   713 ---SNMPFRLVTRESR-ALAFKFLDSLNETCVLECHTEIQAQMSL-----------PSQDPKCQD 762
               ...|.|:.:|... |||             ...|..:|.:.:           ||.||....
  Rat   553 TLNQKQPLRVPSRSGHGALA-------------PGRTPARAGLPVLSRKEGMDRRGPSLDPHPHP 604

  Fly   763 RNIANSLLLVTGLKPDTRYNLHFYNCKTRIFYGDIDEKTEQ-----DPPGTISNSKLIKQNGLKL 822
            |           ::|......|..:....   ..:|.|.:.     ||....|.|.
  Rat   605 R-----------VEPSASSAYHQLSSTDN---DSVDRKEDDQAGSPDPKAASSGSS--------- 646

  Fly   823 MWEPPINP-NGRVHHYDIRWSLDNVTHEAIVKECTKCSYKFPNVSETAKIHVAVRVMGDTGAGAP 886
                |.|| ..|......|.:..|:                  :.:.:::|...:....:.:
  Rat   647 ----PKNPGRSRPTSAPSRHAASNM------------------LRDKSRVHPGTKAASSSTS--- 686

  Fly   887 MYFDMINNNHTWLKEESESSHSEVYSGIAIGSLLSIACVFLFGLFIIFQQRNFKARAQGPTHLTT 951
                  ..:|:...||..|:.                           ..|:|      |.|
  Rat   687 ------RQSHSSTSEEDSSAQ---------------------------PSRHF------PLH--- 709

  Fly   952 PTDINFGNLSSASGMPGDSAGGLSGGTL-QQDCHEMQTLIPRSRYHIELLPEHSLEYQTSTAAVA 1015
                           .|.|...||.|.. :||.|.                  |..:.||..|.:
  Rat   710 ---------------RGSSTSPLSRGWKDRQDTHA------------------SSSHTTSRTASS 741

  Fly  1016 VVHLANGNGSVQVARRSDQDGAAQGDLGIAGVHNLSQLPLCGVGGTSPERKTVQDAMLQEAKAFY 1080
            ....|...||.:....:|.|.||:..:..|......|....|:|..|          |...|.|
  Rat   742 SHPSALTEGSEEEDGGADSDRAAEDTIRRAEATAQIQQTRPGLGHFS----------LIRNKPF- 795

  Fly  1081 IPYRHTPPNAVALSSSK---QCAVPSGSELEVIVPPNSLPLVTTMPGLGVVGGG----------- 1131
            .|:...|.....|...:   ..:..|.|..:|:....|||...|.||..|.|.|
  Rat   796 TPHSRNPNRFPRLRGPRLQPSVSPQSTSASKVLTRSPSLPASHTRPGSDVYGDGEDEEPLPATVI 860

  Fly  1132 -------------GSG-----GGGVGGSSRRSGSLSSSSASSSSNG--------SSKKQFHTNFV 1170
                         ||.     |...|.|..|...:..:|.::.::.        |||.|
  Rat   861 NDRTPSYPRHPISGSSDTLRRGPQRGASLYRKEPIPENSKAAGADVPPGGRSPLSSKAQ------ 919

  Fly  1171 RHSNSNDGIYLLAEEEAAATLTPTSEREYAAVCLTNGFKLPADVAK-SGGGTY--NTTNNNNSST 1232
                   |......:|.|...:|.|.....:..     :.||..:: |.|.|.  ..|.:.:|..
  Rat   920 -------GFQQSTTDEGAPQTSPASTSRQPSPA-----RPPASRSQPSPGSTVPRRMTPDRSSEL 972

  Fly  1233 NTSQKS-------------------ATAKER-------QPRGNGNPISFSHNACKVPANGPASVN 1271
            ::||..                   .||..|       |.:..|...::..|:.::  .||.|..
  Rat   973 SSSQSKDRSLSQPKLSVAHAGHDHPHTANSRGVLPSAPQNQNEGAQSTYEDNSTEI--EGPDSRT 1035

  Fly  1272 VNHSSAVK--------------QSW-------------------PAATVVHRRAQV 1294
            ..||:..|              |||                   |.:|  |.||||
  Rat  1036 PTHSARAKDTTPPILKPRQVGSQSWSSDNRPQPSQAGASERPIRPGST--HPRAQV 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plum	NP_001163744.1	IG_like	170..241	CDD:214653	9/70 (13%)
		IGc2	175..235	CDD:197706	8/59 (14%)
		IG_like	284..356	CDD:214653	8/71 (11%)
		I-set	360..443	CDD:254352	16/82 (20%)
		IGc2	378..435	CDD:197706	10/56 (18%)
		FN3	804..886	CDD:238020	11/82 (13%)
Fndc1	XP_006227933.1	FN3	37..117	CDD:214495	13/61 (21%)
		FN3	155..238	CDD:214495	20/138 (14%)
		FN3	258..351	CDD:238020	25/170 (15%)
		fn3	359..444	CDD:278470	20/129 (16%)
		Treacle	530..1059	CDD:281536	120/699 (17%)
		FN3	1595..1686	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900