DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plum and cdon

DIOPT Version :9

Sequence 1:	NP_001163744.1	Gene:	plum / 43197	FlyBaseID:	FBgn0039431	Length:	1298	Species:	Drosophila melanogaster
Sequence 2:	NP_001075097.1	Gene:	cdon / 280652	ZFINID:	ZDB-GENE-021115-4	Length:	1125	Species:	Danio rerio

Alignment Length:	1156	Identity:	215/1156 - (18%)
Similarity:	369/1156 - (31%)	Gaps:	355/1156 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 SGEYYCKIEWDESAVISDRITVEYPVLKRLFPGQQQAANISALENKPLVLSCPF-LSVPAA---- 191
            :|.|.|....:..::||....|....::......:::..::  :....|:.||. .|.|.|
Zfish    93 TGSYQCSARSETGSIISRHARVTIADIEEFAETHRRSFTVN--KGDTAVIECPLPRSNPPALPRF 155

  Fly   192 --RFSWYFGNDSLTNDNSALILTNGTLILRHLRLEQAGKYKCVAQNTFASKTHRQFIWQLQVEPK 254
              |..|.   :..|::  .|||.:|.|.:..:..|..|.|||.|.|....:|        :||..
Zfish   156 RIRGKWL---EQSTDE--YLILPSGNLQIVSVSSEHQGMYKCGAYNPLTRET--------RVEAH 207

  Fly   255 DATFYPKNEAGITETAVSEAQLLPAFQNATVFVPAGGSVLLQCHAVADFVPIVWYLQPPNNKMVR 319
            ......|:    :|:: |..:::......::.|...||:.|:|......           :..|:
Zfish   208 GTKLLVKD----SESS-SPVRIVYPITPRSLTVDQSGSLTLECVVSGSL-----------SSKVK 256

  Fly   320 LSNNSVAYSITNASIARHE------------GRYSCITPLE-----TQNFQVIVTTPPRIVSRLP 367
            ...|....|:::..:..|.            |.|||..|.:     :.|:.|.|.....|:..|.
Zfish   257 WMKNGAELSLSSKRMLSHSNLVLNDIQPGDGGHYSCSVPTDRGAVVSVNYTVNVLAHVSILRGLS 321

  Fly   368 VEVVYIGLSRTLTCRAEGHPEPSITWYHNGVHLNSSYTRYISGNELHVHSFDSKEEGIYQCVARN 432
            .:....|.|...||.|.|:|.|:|||..|...|:||....|||..|.:.|...:::|||||:..|
Zfish   322 DQAAVAGSSVRFTCAASGNPTPNITWLLNAAPLSSSPRLKISGTSLLISSTTLQDQGIYQCMFDN 386

  Fly   433 VAGEDSATGELRFNRQLEEVNPLQNIRCYPHSFHSINITFDSRTLTSMFVVYIVRNNPHSWTSFS 497
            ......:||.|             :|:..|.|              |......|:..|    |..
Zfish   387 GISSAQSTGRL-------------SIQSEPQS--------------SSISAVPVKTQP----SVH 420

  Fly   498 PMKLNQTSYVVISTDLPVYEPFALITRVLFPTTEVRTGTLVPQQMILSSLRSTPVTCCTQGLMLR 562
            |::.::...:.:|..      .|.:...:.|.|| |.|.           |.||..
Zfish   421 PIQSDEGDELFLSMG------EAALGETVGPPTE-RIGD-----------RPTPEA--------- 458

  Fly   563 PIAVG-------NDTFVKWSQGQ---LENKKYFILQFSINHTHPHPAQLLNGSLQGTLTSVEEKA 617
            ||.:.       |...::|..|:   :....||:....::..         |::.|:..:|....
Zfish   459 PIIISPPQTHKPNMYDLEWRAGRDWGIAIIAYFVKYRKVDDM---------GNVVGSWHTVRVPG 514

  Fly   618 DQVRHHLTEIQPLNQSAAATVLRNVEHEDNVVDDTLELEDDIFSLVVDASVTGILL-------QR 675
            .:....|:|::|.:......|.|:...|......|.....:..|...:.|...|:.       .:
Zfish   515 SEKSLPLSELEPSSLYEVLMVARSAAGEGQPAMLTFRTGKERASPNKNPSKAPIVSLPEKTPEDK 579

  Fly   676 FTRIKMRVLI--------------ITTENEFLGQDFRYVQWKIIENGTSEQSNMPFRLVTRESRA 726
            .|.....|:|              :.||:..      ||.|....||.|..:  .||:..|:
Zfish   580 TTNTYYGVVIHDRVPEAPDRPTISMATESSV------YVTWIPRANGGSPIT--AFRVEYRK--- 633

  Fly   727 LAFKFLDSLNETCVLECHTEIQAQMSLPSQDPKCQDRNIANSLLLVTGLKPDTRYNLHFYNCKTR 791
                  ...|...::........::|:.                 |..|:|.:.|.........
Zfish   634 ------QGRNGDWIIAADNISPLKLSVE-----------------VRNLEPGSTYRFRVIAMNN- 674

  Fly   792 IFYGDIDEKTEQDP-------------PGT---ISNSKLIKQNGLKLMW--EPPINPNGRVHHYD 838
              ||:........|             |.|   ||::..:....:.|.|  .|..|.|..:..:.
Zfish   675 --YGESPASATSRPYQVSMSSSPVSNRPVTGPHISSTDAVSDTQILLRWTYTPSSNNNTPIQGFY 737

  Fly   839 IRWSLDNVTHEAIVKECTKCSYKFPNVSETAKIHVAVRVMGDTGAGAPM--YFDMINNNHTWLKE 901
            |.:...:..:::..|:.....:||        .|:...:..:|.....|  |.|
Zfish   738 IYYRPTDSDNDSDYKKDVVEGFKF--------WHMIGELQPETSYDIKMQCYND----------- 783

  Fly   902 ESESSHSEV------------------------YSG-----------IAIGSLLSIACVFLFGLF 931
            ..||.:|.|                        |..           :.:|.:|.:..:.|. :|
Zfish   784 GGESEYSNVMICETKARQPPGVPSLRPITPPGFYPADTPSQPGGLLYLIVGCVLGVMVLILL-VF 847

  Fly   932 IIF-----QQRNFKARAQGPTHLTTPTDINFGNLSSASGMPGDS--------AGGLSGGTLQQDC 983
            |:.     :|:|...:...|.::....::| |::...|.:||.|        ..|.:...:.|.|
Zfish   848 IVMCLWRNRQQNSMHKYDPPNYIYQSAEMN-GHVLDYSALPGSSHVNGSVHTGCGHTAPMMPQTC 911

  Fly   984 HEMQTLIPRS----------------RYHIELLPEHSLEYQTSTAAVAVVHLANGNGSVQVARRS 1032
            |.:...:|..                ..|...|.::::||:..:..    ||.||.|......::
Zfish   912 HHLHHKLPNGLALLNGSGGLYPAGHPHAHDTSLHQNNMEYEHPSPH----HLHNGGGIYTALPQN 972

  Fly  1033 DQD---------------------------------GAAQGDLGIAGVHNLSQLPLCGV-----G 1059
            |..                                 .|.|.|       .|..:||..:     |
Zfish   973 DSSDCMSCQNFCNNNRCYTKTNGTFSGGTLPLMHRVAARQPD-------GLEMMPLNPILSRCHG 1030

  Fly  1060 GTSPERKTVQDA-MLQEAKAFYIPYRHTPPNAVALSSSKQC-AVPSGSELE 1108
            ..||:....||. .:|:|:...:|         .||.:..| .|.:.|.||
Zfish  1031 RDSPQLNGCQDRDSVQQAEEGNVP---------PLSHNSPCLPVETKSSLE 1072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plum	NP_001163744.1	IG_like	170..241	CDD:214653	21/77 (27%)
		IGc2	175..235	CDD:197706	20/66 (30%)
		IG_like	284..356	CDD:214653	16/88 (18%)
		I-set	360..443	CDD:254352	30/82 (37%)
		IGc2	378..435	CDD:197706	24/56 (43%)
		FN3	804..886	CDD:238020	16/99 (16%)
cdon	NP_001075097.1	Ig	30..116	CDD:299845	6/22 (27%)
		IG_like	35..116	CDD:214653	6/22 (27%)
		IG_like	131..213	CDD:214653	24/96 (25%)
		Ig	139..196	CDD:299845	20/61 (33%)
		IG_like	230..310	CDD:214653	16/90 (18%)
		IGc2	239..294	CDD:197706	12/65 (18%)
		I-set	315..399	CDD:254352	31/96 (32%)
		Ig	317..399	CDD:299845	30/94 (32%)
		FN3	456..552	CDD:238020	18/113 (16%)
		FN3	594..685	CDD:238020	19/127 (15%)
		FN3	700..797	CDD:238020	22/115 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	1	0.960