DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plum and Neo1

DIOPT Version :9

Sequence 1:	NP_001163744.1	Gene:	plum / 43197	FlyBaseID:	FBgn0039431	Length:	1298	Species:	Drosophila melanogaster
Sequence 2:	NP_032710.2	Gene:	Neo1 / 18007	MGIID:	1097159	Length:	1492	Species:	Mus musculus

Alignment Length:	1372	Identity:	260/1372 - (18%)
Similarity:	448/1372 - (32%)	Gaps:	342/1372 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCLFYNRRLF----VIQLIEILLLLLTDHNGRLTLTKESTTVAAAVAQPKNSTALQPYLQIQKHA 61
            :|...:||..    ::.|:.:||||....:| ...||..:...:|.|..:..|..  |..::...
Mouse    11 LCTSSSRRCCPPPPLLLLLPLLLLLGRPASG-AAATKSGSPPQSAGASVRTFTPF--YFLVEPVD 72

  Fly    62 VTRLTISKPHSPYYLPCIPILTPYNHDQDNQPIYCSWYRNDVVVEQVSYRKN----DFFIYDNGT 122
                |:|...|...|.|    :.|:....|    ..|.::...:...|..:.    |..::.:..
Mouse    73 ----TLSVRGSSVILNC----SAYSEPSPN----IEWKKDGTFLNLESDDRRQLLPDGSLFISNV 125

  Fly   123 LRLPTNEKASGEYYCKIEWDESAVISDRITVEYPV--LKRLFPGQQQAANISALENKPLVLSCPF 185
            :....|:...|.|.|....|....|..| |.:..|  |.| |..|.:.:::..  ....:|:|..
Mouse   126 VHSKHNKPDEGFYQCVATVDNLGTIVSR-TAKLTVAGLPR-FTSQPEPSSVYV--GNSAILNCEV 186

  Fly   186 LS--VPAARFSWYFGNDSLTNDNSALILTNGTLILRHLRLEQAGKYKCVAQNTFASKTHRQFIWQ 248
            .:  ||..|  |......|..|:..:.|.:|||::.:......|.|:|:.::....|
Mouse   187 NADLVPFVR--WEQNRQPLLLDDRIVKLPSGTLVISNATEGDGGLYRCIVESGGPPK-------- 241

  Fly   249 LQVEPKDATFYPKNEAGITETAVSEAQLLPAFQNATVFVPAGGSVLLQCHAVADFVPIVWYLQ-- 311
                     |..:.|..:.:.......|:...:.:::....|.|.:|.|.......|:|.:::
Mouse   242 ---------FSDEAELKVLQDPEEIVDLVFLMRPSSMMKVTGQSAVLPCVVSGLPAPVVRWMKNE 297

  Fly   312 -----PPNNKMVRLSNNSVAYSITNASIARHEGRYSCIT-----PLETQNFQVIVTTPPRIVSRL 366
                 ..:.::|.|:...:..|......|   |.|.||.     .:|.| .::.|..||..:.:
Mouse   298 EVLDTESSGRLVLLAGGCLEISDVTEDDA---GTYFCIADNGNKTVEAQ-AELTVQVPPGFLKQ- 357

  Fly   367 PVEV-VYIGLSRTLTCRAEGHPEPSITWYHNG-VHLNSSYTRYISGNELHVHSFDSKEEGIYQCV 429
            |..: .:..:.....|...|.|.|::.|..|| |.:.|.|.:.:..:.|.|......:||.|||:
Mouse   358 PANIYAHESMDIVFECEVTGKPTPTVKWVKNGDVVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCI 422

  Fly   430 ARNVAGEDSATGELRFNRQLEEVNPLQNIRCYPHSFHSINI-TFDSRTLTSMFVVYIVRNNPHSW 493
            |.|..|...|..:|..   ||               |.:.| |....:|||....::..
Mouse   423 AENDVGNAQAGAQLII---LE---------------HDVAIPTLPPTSLTSATTDHLAP------ 463

  Fly   494 TSFSPM---------KLNQTSYVVISTDLPVYEPFA-LITRVLFPTTE----------------- 531
            .:..|:         .|..|.::.::...|..:|.. .:|..:|.|.|
Mouse   464 ATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGVARERVENTSQPGEMQ 528

  Fly   532 VRTGTLVPQQMIL----------SSLRSTPVTCCTQGLMLRPIAVGN---------DTFVKW--- 574
            |....|:|..:.:          |...|.|:...||..:..|....|         ...|.|
Mouse   529 VTIQNLMPATVYIFKVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNIRAYATSPTSITVTWETP 593

  Fly   575 --SQGQLENKKYFILQFSINHTHPHPAQLLNGSLQGTLTSVEEKADQVRHHLT--EIQPLNQSAA 635
              ..|:::|.|.:.::                  :|  |..|:..|...|..|  .::...:.:.
Mouse   594 LSGNGEIQNYKLYYME------------------KG--TDKEQDIDVSSHSYTINGLKKYTEYSF 638

  Fly   636 ATVLRNVEHEDNVVDDTLELEDDIFSLVVDASVTGILLQRFTRIKMRVLI------ITTEN-EFL 693
            ..|..| :|...|  .|.::.....|.|..|:...:.|:  .|....::|      .||:| :..
Mouse   639 RVVAYN-KHGPGV--STQDVAVRTLSDVPSAAPQNLSLE--VRNSKSIVIHWQPPSSTTQNGQIT 698

  Fly   694 GQDFRYVQWKIIENGTSEQSNMPFRLVTRESRALAFKFLDSLNETCVLECHTEIQAQMSLPSQDP 758
            |...||                  |..:|:|         .:.||.|    |..|....:...|
Mouse   699 GYKIRY------------------RKASRKS---------DVTETLV----TGTQLSQLIEGLD- 731

  Fly   759 KCQDRNIANSLLLVTGLKPDTRYNLHFYNCKTRIFYGDIDEKTEQDPPGTISNSKLIKQNGLKLM 823
            :..:.|...:.|.|.|..|.|.:      .....|..|:||....:.|.::....|:  ..:.:.
Mouse   732 RGTEYNFRVAALTVNGTGPATDW------LSAETFESDLDETRVPEVPSSLHVRPLV--TSIVVS 788

  Fly   824 WEPPINPNGRVHHYDIRWSLDNVTHEAIVKECTKCSYKFPNVSETAKIHVAVRVMGDTGAGAPMY 888
            |.||.|.|..|..|.|.:.:.:...:.|..:..:..|...|:..::...:.::...:.|.|.|:|
Mouse   789 WTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLY 853

  Fly   889 FDMINNNHTWLKE--------------------------ESESSHSEVYSGIAIGSLLSIACVFL 927
            ...:...||...|                          .|..||..:....|..||....
Mouse   854 ESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQ---- 914

  Fly   928 FGLFIIFQQRNFKARAQGPTHLTTPTDINFGNLSSASGMPGDSAGGLSGGTLQQDCHEMQTLIPR 992
                .|...|.:..|.:  |::...|.....|.::.|.:    ..||...||    :|...::.:
Mouse   915 ----KITDSRYYTVRWK--TNIPANTKYKNANATTLSYL----VTGLKPNTL----YEFSVMVTK 965

  Fly   993 SRYH-----------IELLPEHSLEYQTSTAAVAVVHLANGNGSVQVAR---RSDQDGAAQG--- 1040
            .|..           .||:|       ||......|....|.....:..   .|:.:|...|
Mouse   966 GRRSSTWSMTAHGATFELVP-------TSPPKDVTVVSKEGKPRTIIVNWQPPSEANGKITGYII 1023

  Fly  1041 ----DLGIAGVHNLSQLPLCGVGGTSPERKT--VQDAMLQEAKAFYIPYRHTPPNAVALSSSKQC 1099
                |:. |.:|:....|:.|      .|.|  :|:..|.....|.|..|:: .....:|.:.|.
Mouse  1024 YYSTDVN-AEIHDWVIEPVVG------NRLTHQIQELTLDTPYYFKIQARNS-KGMGPMSEAVQF 1080

  Fly  1100 AVPSGSELEVIVPPNSLPLVTTMPGLGVVGGGGSGGGGVGGSSRRSGSLSSS-----SASSSSNG 1159
            ..|.....:            .||....:|..|.|.        |...|.|.     |.|:|.:|
Mouse  1081 RTPKADSSD------------KMPNDQALGSAGKGS--------RLPDLGSDYKPPMSGSNSPHG 1125

  Fly  1160 SSKKQFHTNFVRHSNSNDGIYLLAEEEAAATL----TPTSEREYAAVCLTNGFKLPADVAKSGGG 1220
            |......:|.:.....:.|:..:......|..    |.:.:::..|.|            ||..|
Mouse  1126 SPTSPLDSNMLLVIIVSVGVITIVVVVVIAVFCTRRTTSHQKKKRAAC------------KSVNG 1178

  Fly  1221 TYNTTNN 1227
            ::....|
Mouse  1179 SHKYKGN 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plum	NP_001163744.1	IG_like	170..241	CDD:214653	15/72 (21%)
		IGc2	175..235	CDD:197706	15/61 (25%)
		IG_like	284..356	CDD:214653	16/83 (19%)
		I-set	360..443	CDD:254352	23/84 (27%)
		IGc2	378..435	CDD:197706	19/57 (33%)
		FN3	804..886	CDD:238020	15/81 (19%)
Neo1	NP_032710.2	Ig1_Neogenin	65..159	CDD:143199	19/106 (18%)
		I-set	65..159	CDD:254352	19/106 (18%)
		I-set	163..250	CDD:254352	21/108 (19%)
		IGc2	177..236	CDD:197706	15/60 (25%)
		I-set	261..348	CDD:254352	16/90 (18%)
		IGc2	274..337	CDD:197706	14/65 (22%)
		I-set	352..438	CDD:254352	24/86 (28%)
		Ig4_Neogenin	368..438	CDD:212460	22/69 (32%)
		FN3	470..563	CDD:238020	14/92 (15%)
		FN3	570..659	CDD:238020	18/111 (16%)
		FN3	667..759	CDD:238020	24/131 (18%)
		FN3	770..849	CDD:214495	14/80 (18%)
		FN3	887..980	CDD:238020	19/110 (17%)
		FN3	987..1082	CDD:238020	20/102 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1072..1128		16/75 (21%)
		Neogenin_C	1189..1492	CDD:284094
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1205..1237
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1266..1300
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1321..1399
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900