DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plum and unc-40

DIOPT Version :9

Sequence 1:	NP_001163744.1	Gene:	plum / 43197	FlyBaseID:	FBgn0039431	Length:	1298	Species:	Drosophila melanogaster
Sequence 2:	NP_491664.1	Gene:	unc-40 / 172233	WormBaseID:	WBGene00006776	Length:	1415	Species:	Caenorhabditis elegans

Alignment Length:	1459	Identity:	288/1459 - (19%)
Similarity:	456/1459 - (31%)	Gaps:	483/1459 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 SPYYLPCIPILTPYNHDQDNQPIYCSWYRNDVVV-EQVSYRKNDFFIYDNGTLRLPTNEKA-SGE 134
            |.:.|.|..:|.   |::....:...|.|:.|:: |:.|.|   ..:..||:|.:.:...| .|.
Worm    57 SSHLLECSYVLA---HERLVHDVRIEWKRDGVLLSERTSSR---IKVMSNGSLWIESVSSAEEGT 115

  Fly   135 YYCKIEWDESAVISDRITVEYPVLKR--------LFPGQQQAANISALENKPLVLSCPFLSVPAA 191
            |.|.:   .....||:.:..:..|.|        |...:.||.:.:..:.:|....|...|.|..
Worm   116 YQCAV---HVTTKSDQTSDTWTFLSRKATLRLADLAKFELQAIDRTLAKGQPTAFHCLINSKPTP 177

  Fly   192 RFSWYFGNDSLTNDNSALIL-TNGTLILRHLRLEQAGKYKCVAQNTFASKTHRQFIWQLQVEPKD 255
            ...|...::.:.|.....|| .:.||.:...:....|.|:|..:.  |.|.......:|.|
Worm   178 TAVWLHNDEPIVNGGEYHILPVSNTLEISSTQSRHEGTYRCTVEG--AGKRRSSQTARLTV---- 236

  Fly   256 ATFYPKNEAGITETAVSEAQLL--PAFQNATVFVPAGGSVLLQCHAVADFVPIVWYLQPPNNKM- 317
                      .|||..:|...:  |..|    .|..|...||:|...:...|.|.:|:.....:
Worm   237 ----------TTETVSNELVFITTPRLQ----VVEQGDEFLLECLVASLIRPQVRWLKDSRQIIV 287

  Fly   318 --VRLSNNSVAYSITNASIARHEGRYSCITPLETQNF----QVIVTTPPRIVSRLPVEVVYIGLS 376
              ||:....|:..:.:.:.....|.|:|.......:.    .|.|..||||.:|...:|......
Worm   288 DGVRIRRVGVSSILVSRASIEDTGLYTCRASNNDDSIDRAVSVEVRAPPRITTRPTTKVAVETAD 352

  Fly   377 RTLTC-RAEGHPEPSITWYHNGVHLNSSYTRYISGNELHVHSFDSKEEGIYQCVARNVAGEDSAT 440
            ..|.| .|...||..:.||.||..:..|....|..|.|.:......::.||||:|.|..|.:.|:
Worm   353 VELECGTAAARPEARVNWYKNGEAIIGSEYFVIEPNRLRILGVVRADQAIYQCIAENDVGSEQAS 417

  Fly   441 GELRFNRQLEEVNPLQNIRCYPHSFHSINITFDSRTLTSMFVVYIVRNNPHSWTSFSPMKLNQTS 505
            .:|..:..                        ||.::.:...|        ..||.:|:.|..||
Worm   418 AQLLVDAP------------------------DSSSVAASSGV--------PMTSSAPLGLRSTS 450

  Fly   506 ----YVVISTDLPV--------YEPF---ALITR---VLFPTTEVRTGTLVPQQMIL-------- 544
                ::.:..|.||        |..|   .||.|   :...:|.....:|.|..|.|
Worm   451 SGSRFINVEWDPPVQRNGNIMRYHIFYKDNLIDRERMINSSSTSATLTSLQPSTMYLIRVTAENE 515

  Fly   545 -------SSLRSTPVTCCTQGL-----MLRPIAVGNDTF-VKWSQ---GQ-------------LE 580
                   .||:.|  |...|.:     .|...|.|.:|. ::||.   ||             ||
Worm   516 AGMGKFSDSLKVT--TNKEQAVPGKVASLTTTATGPETIDIRWSPPSGGQPALRYKIFYSHDPLE 578

  Fly   581 -NKKYFILQFSINHTHPH------------PAQLLNGS-LQGTLTSVEEKADQVRHHLTEIQPLN 631
             |:|..::..|..|...|            .|:..||| |......|..::|:     ....|:|
Worm   579 KNEKETLITTSTTHYTLHGMDKYTGYQIRIEAEGSNGSGLSSDTVKVRTQSDE-----PSAPPVN 638

  Fly   632 QSAAATVLRNVEHEDNVVDDTLELEDDIFSLVVDASVTGILLQRFTR---IKMRVLII-TTENEF 692
            ..|.|....:|    .|..|..|.|.      |:..:||..|:..|:   .|...|:| .|..|:
Worm   639 IQAEADSSTSV----RVSWDEPEEES------VNGEITGYRLKYKTKARGAKGNTLVIDATAREY 693

  Fly   693 ----LGQDFRY-VQWKII-ENGTSEQS-----NMPFRLVTRESRAL------------------- 727
                |..:.:| ::..:: .|||...|     :.|.:  .:|.|.|
Worm   694 TMGNLEPNTQYLIRMAVVNHNGTGPFSDWVSIDTPGQ--DKEERTLGAPREIRPHAGIDYILVSW 756

  Fly   728 -------------------------AFKFLDSLNETCVLECHTEIQAQMSL-------------- 753
                                     ..:...|..:..:...|:|....:||
Worm   757 LPPADEQNLVRGYQIGWGLSVPDTETIRVTASTTQYKIARLHSERDYVISLRAFNNLGSGFPIYE 821

  Fly   754 ---------PS---QDPKCQDRNIANS-------------------------------------- 768
                     ||   :|....|.::.:|
Worm   822 TVRTLSRETPSHFNEDSDSDDSDVGSSESTPVGVRAEAISATSIRVMWTESDETAFNTQYTVRYS 886

  Fly   769 ----------------LLLVTGLKPDTRY-----------NLHFYNCKTRIFYGDIDEKTEQDPP 806
                            ...|.||:|.|.|           .|..::..||       .:|...||
Worm   887 TAVDGNQHRYVNSTETWATVEGLRPATEYEFAVRAVASNGQLSTWSMATR-------NRTLAAPP 944

  Fly   807 G------TISNSKLIKQNGLKLMWEPPINPNGRVHHY-----------DIRWSL-----DNVTHE 849
            .      |:..::....:...|.|:||...||.:..|           |..|::     |.::|:
Worm   945 SSAPRDLTVLPAESGDPHSSSLHWQPPKYSNGEIEEYLVFYTDRASLADKDWTINYVAGDKLSHQ 1009

  Fly   850 AIVKECTKCSYKFPNVSETAKIHVAV-RVMGDTGAGAPMYFDMINNNHTWLKEESESSHSEVYSG 913
             :.....|.:|.|...:...|.|... .|:|.|.:|..:......:|        ...|....||
Worm  1010 -VSNLLPKANYFFKIQARNEKGHGPFSSVVGYTPSGGAILSGKDRHN--------ARGHGSAASG 1065

  Fly   914 IAIG------SLL-----------SIACVFLFGLFII----FQQRNFKARAQGPTHLTTPTDINF 957
            ..:.      |||           :.|.:.:..|.:|    :::.:...|..|         ...
Worm  1066 DTVSLVDQLQSLLHSNPLYLILLAAFALILILTLILIIMCCWKRSSGGGRKNG---------YQS 1121

  Fly   958 GNLSSASGMPGDSAGGLSG--------------------------GTLQQDCHEMQTLIPRSRYH 996
            |..:||....|...|||.|                          .|......::::  |..|||
Worm  1122 GKKTSAGAGSGGGIGGLGGPPNDLWINGTGSHMRAGASDYMVDGLATAHLTAADIES--PTPRYH 1184

  Fly   997 IELLPEHSL--EYQTSTAAV-------AVVHLANGNGSVQVARRSDQDGAAQGDLGIAGVHNLSQ 1052
             .|..:.:|  .|..|:.::       .||:  .|.|..|..:|.|.: :..|.....|..:...
Worm  1185 -HLQGQGTLTRSYHQSSQSLEGRQRTPQVVY--TGTGRHQPIQRIDFE-SPYGSSSAIGSASTPP 1245

  Fly  1053 LPLCGVGGTSPERKTVQDAMLQEAKAFYIPYRHTPPNAVALSSSKQCAVPSGSELEVIVPP---- 1113
            ||:.......|   ||.|.        |...|.||||     ||...|:.|.::|....||
Worm  1246 LPMQAPPSGPP---TVIDG--------YRTLRGTPPN-----SSAANALRSFTQLAGATPPPPHS 1294

  Fly  1114 ----NSLPLV-------------TTMPGLGVVG-----GGGSGGGGVGGSSRRSGSLS------- 1149
                :|.|.:             |..|.:.|..     ...|.....|.|.::||...
Worm  1295 AASSSSRPTIIAAGGRQVPVGRATAQPRVNVANIYSPFASCSASSDAGESDKKSGECMEMRETTP 1359

  Fly  1150 -SSSASSSSNGSSKKQFHTNFVRHSNSND 1177
             .|:.:.||||   ::.:||.....::.|
Worm  1360 IKSNTAGSSNG---EKMNTNMNPSHSAED 1385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plum	NP_001163744.1	IG_like	170..241	CDD:214653	14/71 (20%)
		IGc2	175..235	CDD:197706	13/60 (22%)
		IG_like	284..356	CDD:214653	15/78 (19%)
		I-set	360..443	CDD:254352	26/83 (31%)
		IGc2	378..435	CDD:197706	19/57 (33%)
		FN3	804..886	CDD:238020	23/104 (22%)
unc-40	NP_491664.1	I-set	42..130	CDD:254352	20/81 (25%)
		Ig	43..142	CDD:299845	22/93 (24%)
		I-set	149..236	CDD:254352	18/88 (20%)
		Ig	158..237	CDD:299845	17/94 (18%)
		IG_like	251..332	CDD:214653	17/84 (20%)
		IGc2	258..320	CDD:197706	13/61 (21%)
		I-set	336..422	CDD:254352	27/85 (32%)
		Ig	352..422	CDD:299845	22/69 (32%)
		FN3	441..529	CDD:238020	20/89 (22%)
		FN3	536..627	CDD:238020	21/90 (23%)
		FN3	635..727	CDD:238020	25/101 (25%)
		FN3	738..816	CDD:214495	5/77 (6%)
		FN3	852..927	CDD:214495	6/74 (8%)
		FN3	946..1038	CDD:238020	17/92 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900