DRSC/TRiP Functional Genomics Resources

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Protein Alignment plum and DCC

DIOPT Version :10

Sequence 1:NP_651482.3 Gene:plum / 43197 FlyBaseID:FBgn0039431 Length:1298 Species:Drosophila melanogaster
Sequence 2:NP_005206.2 Gene:DCC / 1630 HGNCID:2701 Length:1447 Species:Homo sapiens


Alignment Length:939 Identity:186/939 - (19%)
Similarity:325/939 - (34%) Gaps:259/939 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 YLQI---QKHAVTRLT-ISKPHSPYYLPCIPILTPYNHDQDNQPIYCSWYRNDV-VVEQVSYRKN 113
            :||:   |..|.|.|. :|:|.....:....:|...:.:.|.......|.::.: :...:..||.
Human    26 HLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQ 90

  Fly   114 DFFIYDNGTLRLPT------NEKASGEYYCKIEWDESAVISDR---ITVEYPVLKRLFPGQQQAA 169
            ..   .||:|.:..      ::...|.|.|:....:|..|..|   :.|..| |:.|    .|..
Human    91 QL---SNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGP-LRFL----SQTE 147

  Fly   170 NISALENKPLVLSCPFLSVPAARFSWYFGNDSLT---NDNSALILTNGTLILRHLRLEQAGKYKC 231
            :::|.....::|.|..:..|.....|......||   .|:..::|.:|.|.:..|:....|.|:|
Human   148 SVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRC 212

  Fly   232 VAQNTFASKT--------------HRQFIWQLQVEPKDATFYPKNEAGITETAVSEAQLLPAFQN 282
            .|:|..:|:|              ||| ::.||        .|.|...|                
Human   213 SARNPASSRTGNEAEVRILSDPGLHRQ-LYFLQ--------RPSNVVAI---------------- 252

  Fly   283 ATVFVPAGGSVLLQCHAVADFVP--IVWYLQPPNNKMVRLSNNSVAYSI---TNASIAR----HE 338
                  .|...:|:| .|:.:.|  ..|.   ...::::|  .|..||:   :|..|:.    ..
Human   253 ------EGKDAVLEC-CVSGYPPPSFTWL---RGEEVIQL--RSKKYSLLGGSNLLISNVTDDDS 305

  Fly   339 GRYSCITPLETQNF----QVIVTTPPRIVSRLPVEVVYIGLSRTLTCRAEGHPEPSITWYHNG-V 398
            |.|:|:...:.:|.    ::.|..||..::.......|..:.....|...|.|.|::.|..|| |
Human   306 GMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDV 370

  Fly   399 HLNSSYTRYISGNELHVHSFDSKEEGIYQCVARNVAGEDSATGELRFNRQL-----------EEV 452
            .:.|.|.:.:.|:.|.:......:||.|||||.|.||....:.:|...:..           .:|
Human   371 VIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDV 435

  Fly   453 NPLQNIRCYPHSFHSINITFDSRTLTSMFVVYIVRNNPHSWTSFSPMKLN-QTSYVVISTD---- 512
            .|:                    .::|.||..       ||...:..|.| ||..|..|.:    
Human   436 VPV--------------------LVSSRFVRL-------SWRPPAEAKGNIQTFTVFFSREGDNR 473

  Fly   513 ---LPVYEPFALITRVLFPTTEVRTGTLVPQQMILSSL----------RSTPVTCCTQGLMLRPI 564
               |...:|.:|         ::..|.|.|:.|....:          .|.|:...||..:..|.
Human   474 ERALNTTQPGSL---------QLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPG 529

  Fly   565 AVGNDTFVKWSQGQLENKKYFILQFSINHTHPHPAQLLNGSLQGTLTSVEEKADQVRHHLTEIQP 629
            .|.|...|..|            ..||..|...|| ..||.:||           .|...||:  
Human   530 PVENLQAVSTS------------PTSILITWEPPA-YANGPVQG-----------YRLFCTEV-- 568

  Fly   630 LNQSAAATVLRNVEHEDNVVDDTL--ELEDDIFSLVVDASVTGILLQRFTRIKMRVL-------- 684
                       :...|.|:..|.|  :||.               |::||...:|.|        
Human   569 -----------STGKEQNIEVDGLSYKLEG---------------LKKFTEYSLRFLAYNRYGPG 607

  Fly   685 ------IITTENEFLGQDFRYVQWKIIENGTSEQSNMPFRLVTRESRALAFKFLDSLNETCVLEC 743
                  .:.|.::......:.|..:::.:.:.:.|.:|....|:......:|..           
Human   608 VSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIR----------- 661

  Fly   744 HTEIQAQMSLPSQDPKCQDRNIANSLLLVTGLKPDTRYNL--------------HFYNCKTRIFY 794
            |.:...:..:.:.:|.       |...|.|||:..::|:.              ::|..:|.  .
Human   662 HRKTTRRGEMETLEPN-------NLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETP--E 717

  Fly   795 GDIDEKTEQDPPGTISNSKLIKQNGLKLMWEPPINPNGRVHHYDIRWSLDNVTHEAIVKECTKCS 859
            .|:||....|.|.::....  :.|.:.:.|.||:|||..|..|.|.:.:.:...|.:..:..:..
Human   718 NDLDESQVPDQPSSLHVRP--QTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRY 780

  Fly   860 YKFPNVSETAKIHVAVRVMGDTGAGAPMY 888
            |....:..::...::::...:.|.|.|:|
Human   781 YSIERLESSSHYVISLKAFNNAGEGVPLY 809

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
plumNP_651482.3 Ig 179..245 CDD:409353 20/82 (24%)
Ig strand B 179..183 CDD:409353 1/3 (33%)
Ig strand C 192..196 CDD:409353 0/3 (0%)
Ig strand E 214..218 CDD:409353 2/3 (67%)
Ig strand F 228..233 CDD:409353 2/4 (50%)
Ig strand G 242..245 CDD:409353 2/2 (100%)
IG_like 284..356 CDD:214653 16/84 (19%)
Ig 360..443 CDD:472250 24/83 (29%)
Ig strand B 377..381 CDD:409353 0/3 (0%)
Ig strand C 390..394 CDD:409353 0/3 (0%)
Ig strand E 411..415 CDD:409353 1/3 (33%)
Ig strand F 425..430 CDD:409353 3/4 (75%)
Ig strand G 438..441 CDD:409353 0/2 (0%)
FN3 804..886 CDD:238020 16/81 (20%)
DCCNP_005206.2 IgI_1_Neogenin_like 39..136 CDD:409387 17/99 (17%)
Ig strand A 39..42 CDD:409387 1/2 (50%)
Ig strand A' 45..51 CDD:409387 1/5 (20%)
Ig strand B 55..65 CDD:409387 1/9 (11%)
Ig strand C 70..76 CDD:409387 1/5 (20%)
Ig strand C' 78..81 CDD:409387 0/2 (0%)
Ig strand D 88..93 CDD:409387 2/7 (29%)
Ig strand E 95..101 CDD:409387 2/5 (40%)
Ig strand F 113..120 CDD:409387 3/6 (50%)
Ig strand G 125..136 CDD:409387 2/10 (20%)
Ig_3 139..216 CDD:464046 20/81 (25%)
I-set 241..327 CDD:400151 21/121 (17%)
Ig strand B 257..261 CDD:409562 1/3 (33%)
Ig strand C 270..274 CDD:409562 0/3 (0%)
Ig strand E 293..297 CDD:409562 1/3 (33%)
Ig strand F 307..312 CDD:409562 2/4 (50%)
Ig strand G 322..325 CDD:409562 0/2 (0%)
Ig 334..417 CDD:472250 24/82 (29%)
Ig strand B 348..352 CDD:409388 0/3 (0%)
Ig strand C 361..365 CDD:409388 0/3 (0%)
Ig strand E 383..387 CDD:409388 1/3 (33%)
Ig strand F 397..402 CDD:409388 3/4 (75%)
Ig strand G 410..413 CDD:409388 0/2 (0%)
FN3 429..521 CDD:238020 22/127 (17%)
FN3 <478..901 CDD:442628 75/415 (18%)
FN3 946..1041 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1152
Neogenin_C 1148..1445 CDD:461954
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1165..1222
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1288..1330
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1394..1419
Interaction with MYO10. /evidence=ECO:0000269|PubMed:21642953 1432..1439
Blue background indicates that the domain is not in the aligned region.

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