DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plum and Boc

DIOPT Version :9

Sequence 1:	NP_001163744.1	Gene:	plum / 43197	FlyBaseID:	FBgn0039431	Length:	1298	Species:	Drosophila melanogaster
Sequence 2:	NP_766094.1	Gene:	Boc / 117606	MGIID:	2151153	Length:	1110	Species:	Mus musculus

Alignment Length:	1301	Identity:	249/1301 - (19%)
Similarity:	403/1301 - (30%)	Gaps:	447/1301 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 GTLRLPT-NEKASGEYYCKIEWDESAVISDRITVEYPVLKRLFPGQQQAANISALENKPLVLSCP 184
            |||.:.. |....|.|.|.......||.|...||....|:......|....:.  |....|::|.
Mouse    84 GTLVIAALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVD--EGNTAVIACH 146

  Fly   185 F-LSVPAARFSWYFGNDSL--TNDNSALILTNGTLILRHLRLEQAGKYKCVAQNTFASKTHRQFI 246
            . .|.|.|:..:....:.|  :.|| .||:.:|.|.:.:...|..|.|||.|.|
Mouse   147 LPESHPKAQVRYSVKQEWLEASRDN-YLIMPSGNLQIVNASQEDEGMYKCAAYN----------- 199

  Fly   247 WQLQVEPKDATFYPKNEAGITETAVSEAQLLPAFQNATVFVPAGGSVLLQCHAVADFVPIVWYLQ 311
               .|..:..|....:...:..:....|:::...:..||.|..|.|::|:|  ||..:|
Mouse   200 ---PVTQEVKTSGSGDRLRVRRSTAEAARIIYPLEAQTVIVTKGQSLILEC--VASGIP------ 253

  Fly   312 PPNNKMVRLSNNSVAYSIT---------NASIARHEGRYSCITPLETQN-------FQVIVTTPP 360
            ||.....:..::..||:.|         :.:.....|.|.|:......:       :.|.|..||
Mouse   254 PPRVTWAKDGSSIAAYNKTRFLLSNLLIDTTSEEDSGTYRCMASNGVGDPGAAVILYNVQVFEPP 318

  Fly   361 RIVSRLPVEVVYIGLSRTLTCRAEGHPEPSITWYHNGVHLNSSYTRYISGNELHVHSFDSKEEGI 425
            .:...|...|:..|.|..|||...|:|.||:.|..|.|.|.||....:|...|.|.|...::||:
Mouse   319 EVTVELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLTSSQRLRLSRRALRVVSVGPEDEGV 383

  Fly   426 YQCVARNVAGEDSATGELRFNRQLEEVNPLQNIRCYPHSFHSINITFDSRTLTSMFVVYIVRNNP 490
            |||:|.|..|...|..:||..|....:.|.:                |::.:.:.
Mouse   384 YQCMAENAVGSAHAVVQLRTARPDTTLRPGR----------------DTKPIAAT---------- 422

  Fly   491 HSWTSFSPMKLNQTSYVVISTDLPVYEPFALITRVLFPTTEVRTGTL--------VPQQ--MILS 545
                  .||..::.|    ..|..:.|...|:..   ||:.|:..:|        .|.:  :|||
Mouse   423 ------PPMPPSRPS----RPDQMLREQPGLVKP---PTSSVQPTSLKCPGEEQVAPAEAPIILS 474

  Fly   546 SLRSTPVTCCTQGLMLRPIAVGNDTFVKWSQGQLENKKYFILQFSINHTHPHPAQLLNGSLQGTL 610
            |.|::...  :..|:.||...|             :.:..||.:.:.|     .::.|.|...|:
Mouse   475 SPRTSKTD--SYELVWRPRHEG-------------SSRTPILYYVVKH-----RKVTNSSDDWTI 519

  Fly   611 TSVEEKADQVRHHLTEIQP---------------LNQSAAATVLRNVEHEDNVV---DDTLELED 657
            :.:  .|:|.|..||.:.|               ..|:|..|.......:..:|   :..::.:|
Mouse   520 SGI--PANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIVASKEQQIQRDD 582

  Fly   658 DIFSL---------------------VVDASVTGILLQRFTRIKMRVLIITTENEFLGQDFRYVQ 701
            ...||                     :..||.|.:.:....|         ....|..|.||...
Mouse   583 PGASLQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPR---------GNGGFPIQSFRVEY 638

  Fly   702 WKIIENG---TSEQSNMPFRL---VTRESRALAFKF----LDSLNETCVLECHTEIQAQMSLPSQ 756
            .|:.:.|   .:..:..|.||   :|...:.:::||    |:.|.|           ::.|.||:
Mouse   639 KKLKKVGDWILATSAIPPSRLSVEITGLEKGISYKFRVRALNMLGE-----------SEPSAPSR 692

  Fly   757 -------DPKCQDRNIANSLLLVTGLKPDTRYNLH---------------FYNCKTRIFYGDIDE 799
                   ..:..:|.:|...:..|....:|...|.               ||     |:|...|.
Mouse   693 PYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFY-----IYYRPTDS 752

  Fly   800 KTEQDPPGTISNSKLIKQNGLKLMWEPPINPNGRVHH----------YDIRWSLDNVTHEAIVKE 854
            ..:.|                   ::..:....|..|          |||:....|...|:....
Mouse   753 DNDSD-------------------YKKDMVEGDRYWHSISHLQPETSYDIKMQCFNEGGESEFSN 798

  Fly   855 CTKCSYKFPNVS--------------ETAKIHVAVRVMGDTGAGAPMYFDMINNNHTWLKEESES 905
            ...|..|....|              :...:....|.:| |||......|:
Mouse   799 VMICETKARKFSGQPGRPPPLTLAPPQPPPLETMERPVG-TGAMVARASDL-------------- 848

  Fly   906 SHSEVYSGIAIGSLLSIACVFL-FGLFIIFQQRNFKARAQGPTHLTTPTDINFGNLSSASGMPGD 969
              ..:..|:.:||::.|...|: |.|:..:.::..            .||:.|..
Mouse   849 --PYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKH------------TTDLGFPR---------- 889

  Fly   970 SAGGLSGGTLQQDCHEMQTLIPRSRYHIELLPEHSLEYQTSTAAVAVVHLANGNGSVQVARRSDQ 1034
                  ...|...|  ..|::|     :|.||.|.               |||...:
Mouse   890 ------SALLSSSC--QYTMVP-----LEGLPGHQ---------------ANGQPYL-------- 918

  Fly  1035 DGAAQGDLGIAGVHNLSQLPLCGVGGTSPERKTVQDAMLQEAKAFYIPYRHTP------------ 1087
             |...|...::.||.....|...||  .|.||               |.:|.|
Mouse   919 -GGVSGRACVSRVHGSRGCPAATVG--CPGRK---------------PQQHCPGELAQQREDTNS 965

  Fly  1088 -------PNAVALSSSK-----QCA---------VPSGSELEVIVPPNSLPL----VTTMPGLGV 1127
                   .|...|.:.:     |||         :|..|..:::.|.:...|    |||.
Mouse   966 QLRQPIVSNGYDLQNQQVARGPQCASGVGAFLYTLPDDSTHQLLQPQDCCHLQKQPVTTC----- 1025

  Fly  1128 VGGGGSGGGGVGGSSRRSGSLSSSSASSSSNGSSKKQFHTNFVRHSNSNDGIYLLAEEEAAATLT 1192
                             ..::..:|.|.....|....:|:.                .:....|.
Mouse  1026 -----------------QTAVRRTSESPGLESSWDPPYHSG----------------PQCCLGLV 1057

  Fly  1193 PTSEREYAAVCLTNGFKLPADVAKSGGGTYNTTNNNNSSTNTSQKSATAKERQPRGNGNP---IS 1254
            |..|.:            .:|..:.|||.:  ::.:.|.|.|.|      ||..|.:.:|   :|
Mouse  1058 PVEEVD------------SSDSCQVGGGDW--SSQHPSGTYTGQ------ERGMRFSPSPSVHVS 1102

  Fly  1255 F 1255
            |
Mouse  1103 F 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plum	NP_001163744.1	IG_like	170..241	CDD:214653	20/73 (27%)
		IGc2	175..235	CDD:197706	19/62 (31%)
		IG_like	284..356	CDD:214653	19/87 (22%)
		I-set	360..443	CDD:254352	31/82 (38%)
		IGc2	378..435	CDD:197706	24/56 (43%)
		FN3	804..886	CDD:238020	16/105 (15%)
Boc	NP_766094.1	I-set	31..120	CDD:254352	12/35 (34%)
		Ig	35..118	CDD:299845	11/33 (33%)
		IG_like	132..207	CDD:214653	21/91 (23%)
		Ig	138..199	CDD:299845	18/61 (30%)
		Ig	243..301	CDD:299845	13/65 (20%)
		I-set	318..401	CDD:254352	31/82 (38%)
		IGc2	332..393	CDD:197706	26/60 (43%)
		ISET-FN3_linker	404..468	CDD:293231	14/102 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..458		12/89 (13%)
		FN3	481..553	CDD:214495	16/93 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	561..610		4/48 (8%)
		FN3	601..692	CDD:238020	21/110 (19%)
		FN3	707..804	CDD:238020	18/120 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	809..828		1/18 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1065..1110		14/47 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000