DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plum and LOC100332721

DIOPT Version :9

Sequence 1:	NP_001163744.1	Gene:	plum / 43197	FlyBaseID:	FBgn0039431	Length:	1298	Species:	Drosophila melanogaster
Sequence 2:	XP_009295981.2	Gene:	LOC100332721 / 100332721	-ID:	-	Length:	1432	Species:	Danio rerio

Alignment Length:	1392	Identity:	255/1392 - (18%)
Similarity:	430/1392 - (30%)	Gaps:	413/1392 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 PYYLPCIPILTPYNHDQDNQPIYCSWYRNDVVVEQVS-YRKNDFFIYDNGTLRLPT------NEK 130
            |..|.|..|        .:.|:...|.::...:..|: .|:...   .:|:|.:.|      |:.
Zfish    51 PAVLNCSAI--------SDAPVRVEWKKDGTFLNLVADDRRRQL---ADGSLLISTVVHSKHNKP 104

  Fly   131 ASGEYYCKIEWDESAVISDRITVEYPV--LKRLFPGQQQAANISALENKPLVLSCPFLS--VPAA 191
            ..|.|.|....|....||.| |....|  |.|..   .|...:|.......:|||....  ||..
Zfish   105 DEGVYQCVATIDNLGTISSR-TARLTVAGLPRFL---SQPEGVSVRSGGTEMLSCEVTEELVPFT 165

  Fly   192 RFSWYFGNDSLTNDNSALILTNGTLILRHLRLEQAGKYKCVAQNTFASKTHRQFIWQLQVEPKDA 256
            |  |......:..|:..:.|.:|.|::.:.....||.|:|........||..:.  :|||
Zfish   166 R--WDRDARPVELDSRVIQLPSGALVISNASQADAGLYRCTIDGLGPPKTTEEA--ELQV----- 221

  Fly   257 TFYPKNEAGITETAVSEAQLLPAFQN-ATVFVPAGGSVLLQCHAVADFVPIV-WYL--QPPNNKM 317
                     :|::...|.  |...|. ..|....|.||||.|......:|.: |..  ||.....
Zfish   222 ---------VTDSGAGEK--LETLQGPVAVAKVVGESVLLPCVMKGHPIPAIRWTFNDQPIEEAH 275

  Fly   318 VRLS-NNSVAYSITNASIARHEGRYSCITPLETQNF------QVIVTTPPRIVSRLPVEVVYIGL 375
            .|.| ....:..|.|.: ....|.|.|  ..::.|.      ::.|..|||.::|.........:
Zfish   276 ERFSVIGGGSLQIVNLT-EEDAGIYVC--QADSGNMTSEIQAELTVHVPPRFLTRPSNTYAQESM 337

  Fly   376 SRTLTCRAEGHPEPSITWYHNG-VHLNSSYTRYISGNELHVHSFDSKEEGIYQCVARNVAGEDSA 439
            .....|...|.|.|::.|..:| ..:.|.|.|.:..:.|.|......:||.|||:|.|.||...|
Zfish   338 DIIFECDVTGSPPPTVKWMKDGDTVIPSDYFRIVKQHNLQVLGLVKSDEGFYQCLAENDAGNVQA 402

  Fly   440 TGELRFNRQLEEVNPLQNIRCYPHSFHSINITFDSR--TLTSMFVVYIV-----RNNPHSWTSFS 497
            :.:|                    ....|::...|.  :||:....::.     |:.|   |..:
Zfish   403 SAQL--------------------IILDIDVALPSTVPSLTAATTDHVASSGSERSGP---TPSA 444

  Fly   498 P----MKLNQTSYVVISTDLPVYEPFALITRVLFPT-----------------TEVRTGTLVPQ- 540
            |    ..|..|.::.::..||.......||..:|.:                 .:|....|:|.
Zfish   445 PRDVVASLVSTRFIKLTWRLPAEPHGENITYSVFYSLDGTNRERVENTSAPGEMQVTIQNLIPDT 509

  Fly   541 ----QMILSSLR-----STPVTCCTQ--------GLMLRPIAVGNDTF-VKWSQ-----GQLENK 582
                :::.|:..     |.|:|..||        ...|:.::||:.|. :.|.:     |:::..
Zfish   510 KYSFRVVASNANGPGESSAPLTVATQLEVQVPGPAPNLQVVSVGSSTVSLSWERPITGNGEIQTY 574

  Fly   583 KYFILQFSINHTHPHPAQLLNGSLQGTLTSVEEKADQVRHHLTEIQPLNQSAAATVLRNVEHEDN 647
            |.|.::                                                   :..|.|.:
Zfish   575 KLFYIE---------------------------------------------------KGQESEQD 588

  Fly   648 VVDDTLELEDDIFSLVVDASVTGILLQRFTRIKMRVLI-------ITTEN--------------- 690
            |         |:..|    |.|...|::||....||:.       ::||:
Zfish   589 V---------DVSGL----SYTMTSLKKFTEYSFRVVAYNKHGPGVSTEDVTVRTLSDVPSAAPQ 640

  Fly   691 ----EFLGQDFRYVQWKIIE----NGTSEQSNMPFRLVTRESRAL------AFKFLDSLNETCVL 741
                :.|......|:|:...    ||......:.:|...|.:.|:      .|:.:|.|....|.
Zfish   641 NLTLDVLNSTSIMVRWQPPPAGSLNGELTGYKLRYRKGLRRADAVEISTMQIFQLIDGLERGKVY 705

  Fly   742 ECHTEIQAQMSLPSQDPKCQDRNIANSLLLVTGLKPDTRYNLHFYNCKTRIFYGDIDEKTEQDPP 806
                                  .:..|...|.|..|.|.::      ....|..|:||......|
Zfish   706 ----------------------TVRVSATTVNGTGPATEWS------AAETFESDLDESQVPGVP 742

  Fly   807 GTISNSKLIKQNGLKLMWEPPINPNGRVHHYDIRWSLDNVTHEAIVKECTKCSYKFPNVSETAKI 871
            .::....|:  |.:.:.|.||.|....|..|.|.:.:.:.....:..:..:..|...|:..::..
Zfish   743 SSLHVRPLV--NRIVVSWTPPENQEVLVRGYKIGYGIGSPHAHTVTLDYKQRFYSIDNLDASSHY 805

  Fly   872 HVAVRVMGDTGAGAPMY------------------FDMINNNHTWLK-----------EESESSH 907
            .:.::...:.|.|.|:|                  :::.||.:|...           :.|..||
Zfish   806 VITLKAYNNMGEGVPIYNSATTRPQSDPVDPDIDFYELFNNPYTPAPDPTPMLPPVGVQASVLSH 870

  Fly   908 SEVYSGIAIGSLLSIACVFLFGLFIIFQQRNFKARAQGPTHLTTPTDINFGNLSSASGMPGDSAG 972
            ..|....|..||                .:|.|.           ||..:..:...:.:|.::..
Zfish   871 DTVKVSWADNSL----------------AKNQKI-----------TDARYYTIRWKTNIPANTKY 908

  Fly   973 GLSGGTLQQDCHEMQTLIPRSRYHIELLPEHSLEYQT-STAAVAVVHLANGNGSVQVARRSDQDG 1036
            .::..|  ...|.:..|.|.:.|...::...:....| |..|.:..|       ..:...:.:|.
Zfish   909 KMANTT--SLFHTVSALKPNTLYEFSVMVTKNRRSSTWSMTAHSTTH-------ESIPSSAPKDV 964

  Fly  1037 AAQGDLGIAGVHNLSQLPLCGVGGTSPERKTVQDAMLQEAKAFYIPYRHTPPNAVALSSSKQCAV 1101
            ......|...:.|::..|.....|..               ..||.|..|..||
Zfish   965 TVISKEGNPRIININWQPPTEANGKI---------------TGYIIYYSTDVNA----------- 1003

  Fly  1102 PSGSELE--VIVPPNSLPLVTTMPGL--------GVVGGGGSGGGGVGGSSR-RSGSLSSSSASS 1155
                |:.  |:.|.....|...:.||        .:......|.|.:..:.: |:.....|...|
Zfish  1004 ----EVHDWVVEPVVGNRLTHQIQGLTLDTSYFFKIQARNSKGMGPMSDAVQFRTPKAEPSDKMS 1064

  Fly  1156 SSNGSSKKQFHTNFVRH-SNSN---DGIYLLAEEEAAATLTPTSEREYAAVCLTNGFKLPADVAK 1216
            |..|...|..|.....| |.||   .||            |.:.|.....:.:.....:...:|.
Zfish  1065 SDQGLQVKPGHPTLPEHGSGSNMDKQGI------------TGSQENHILVIVVIVSVGVFTIIAV 1117

  Fly  1217 SGGGTYNTTNNNN----------SSTNTSQKSATAKERQPRGNGNPISFSHN-------ACKVPA 1264
            ..|....|..:|:          |||::.:..:::|:.:|     |..:.|:       ..|.|.
Zfish  1118 VVGAVLCTRRSNSHQKKKRAACKSSTSSHKYKSSSKDLKP-----PDLWIHHERLELKPMDKSPE 1177

  Fly  1265 NGPASVNVNHSSAVKQSWPAATVVHRR 1291
            ..|.........:|::  ||....|:|
Zfish  1178 PNPVMTETPIPRSVQE--PAVETSHQR 1202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plum	NP_001163744.1	IG_like	170..241	CDD:214653	16/72 (22%)
		IGc2	175..235	CDD:197706	15/61 (25%)
		IG_like	284..356	CDD:214653	19/81 (23%)
		I-set	360..443	CDD:254352	24/83 (29%)
		IGc2	378..435	CDD:197706	18/57 (32%)
		FN3	804..886	CDD:238020	14/81 (17%)
LOC100332721	XP_009295981.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900