DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14238 and TMEM26

DIOPT Version :9

Sequence 1:	NP_651480.1	Gene:	CG14238 / 43195	FlyBaseID:	FBgn0039429	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_848600.2	Gene:	TMEM26 / 219623	HGNCID:	28550	Length:	368	Species:	Homo sapiens

Alignment Length:	376	Identity:	126/376 - (33%)
Similarity:	191/376 - (50%)	Gaps:	68/376 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IKAILTRIIFSAHSLLAIWQVVALKSDIIYWALCGPLLLLLLEGIFTIMIKKTQEWRWFCPSVFL 72
            :.|:.||::|..|||:.:|:|..:|.:..||.|....|||.||...|:..|:.:.::||.|::||
Human     7 LNALATRLLFLLHSLVGVWRVTEVKKEPRYWLLALLNLLLFLETALTLKFKRGRGYKWFSPAIFL 71

  Fly    73 YLSSIVPAIWLLELDKVARRV---GNMTSTNSTVYSPSNYSIPVGNTTIFITSTNSSGVPPVATL 134
            ||.||||::|||||....:..   ...||.|::.....|.           |.|::........|
Human    72 YLISIVPSLWLLELHHETQYCSIQAEGTSQNTSRKEDFNQ-----------TLTSNEQTSRADDL 125

  Fly   135 LGQAGVTL----SVTPDTWTTLIEQFLMLILIVGRWLLP-KGDLTRDQLSQLLLVYIGTAADIIE 194
            :..|.|.:    :|....||..:.|..:|:||:|||||| .|.:||||||||||:::||||||:|
Human   126 IETAKVFVNNLSTVCEKVWTLGLHQTFLLMLIIGRWLLPIGGGITRDQLSQLLLMFVGTAADILE 190

  Fly   195 F-FDSYKDDSIAKIGFLVFLTLGIWSWSLMQFTIVLSATRGRRPRGSGSHHKEEHTDCCQNCCCG 258
            | .::.::.::.....||:..|.||:||::||.:.|:.                     ||..|.
Human   191 FTSETLEEQNVRNSPALVYAILVIWTWSMLQFPLDLAV---------------------QNVVCP 234

  Fly   259 I-----------------DVWGIVLNVILQDAPFLTFRLLIIFQYKIINYMNVFFTCKNSLVIIL 306
            :                 |:|.|.::|.:||.|||..||:::..:|:||.|.|||..||.||::|
Human   235 VSVTERGFPSLFFCQYSADLWNIGISVFIQDGPFLVVRLILMTYFKVINQMLVFFAAKNFLVVVL 299

  Fly   307 QLYRLYVV----------NAEFWKNRRESRMAKSRQFQSRRKVQDADQNSI 347
            |||||.|:          .:|..|.....|...|....|:|..|:..:..:
Human   300 QLYRLVVLALAVRASLRSQSEGLKGEHGCRAQTSESGPSQRDWQNESKEGL 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14238	NP_651480.1	Tmem26	4..310	CDD:286813	115/327 (35%)
TMEM26	NP_848600.2	Tmem26	3..303	CDD:286813	115/327 (35%)
TMEM26	NP_848600.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..368		5/27 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159075
Domainoid	1	1.000	196	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E1_KOG4610
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	199	1.000	Inparanoid score	I3800
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48045
OrthoDB	1	1.010	-	-		D1097257at2759
OrthoFinder	1	1.000	-	-		FOG0005371
OrthoInspector	1	1.000	-	-		oto90649
orthoMCL	1	0.900	-	-		OOG6_105455
Panther	1	1.100	-	-	O	PTHR22168
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4007
SonicParanoid	1	1.000	-	-		X3811
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.800